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Source: Journal Diabetes Care  Jul 19, 2018  7 years ago
Improving HbA1c levels could reduce the risk of diabetic polyneuropathy among adults with type 2 diabetes, research suggests.   In a new Danish study, each 1% (11 mmol/mol) increase in HbA1c levels among adults with type 2 diabetes during a 10-year period increased polyneuropathy risk by nearly 66%.  The new research used data from the ADDITION-Denmark study, ...
Source: The North American Menopause Society  Jul 20, 2018  7 years ago
Heart disease is still the number one killer of US women, and hormone therapy remains a top treatment for menopause symptoms. A new study connects these two facts to demonstrate little effect of hormone therapy on artery thickness as a precursor to heart disease. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).   According...
Source: University of Edinburgh   Jul 21, 2018  7 years ago
People infected with HIV are twice as likely to suffer from heart disease, research has found. Analysis of global figures reveals that HIV-associated cardiovascular disease has more than tripled in the past 20 years as more people are living longer with the virus.   The greatest impact is in sub-Saharan Africa and Asia Pacific regions, with Swaziland, Botswana and Lesotho particularly ...
Source: University of Warwick  Jul 20, 2018  7 years ago
A clinical trial of the use of adrenaline in cardiac arrests has found that its use results in less than 1% more people leaving hospital alive—but almost doubles the risk of severe brain damage for survivors of cardiac arrest. The research raises important questions about the future use of adrenaline in such cases and will necessitate debate amongst healthcare professionals, patients and the...
Source: Multiple  Jul 19, 2018  7 years ago
Introduction High-sensitivity (hs) cardiac troponin (cTn) assays expedite the evaluation of patients with possible acute coronary syndromes (ACS) in the emergency department. Rapid screening protocols with hscTn have been proposed for patients for whom ruling-in or ruling-out acute myocardial infarction (AMI) is the primary issue. These protocols have not included the entire range of patients w...
Source: University of Tsukuba   Jul 22, 2018  7 years ago
While many candidate citrullinated antigens have been identified in rheumatoid arthritis (RA) joints, their involvement in blood serum remains mostly uninvestigated. A new study from the University of Tsukuba-centered set out to explore the expression and commonality of citrullinated proteins in peptide glucose-6-phosphate isomerase-induced arthritis (pGIA) and patients with RA. The team also went...
Source: Multiple  Jul 21, 2018  7 years ago
In patients with chronic inflammatory conditions, such as rheumatoid arthritis, there has been limited understanding of how this inflammation affects the brain.   A new study published in Nature Communications examines this issue.   "Rheumatoid arthritis is an inflammatory and autoimmune condition with nasty levels of inflammation that can affect a person'...
Source: Multiple  Jul 20, 2018  7 years ago
Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation and tissue damage. SLE can involve many organs and systems and has a poor prognosis. It is one of a large group of autoimmune disorders, which occur when the immune system attacks the body's own tissues and organs.   Type I interferon (IFN-I), a key protein that regulates the immune system's activity, i...
Source: Multiple  Jul 19, 2018  7 years ago
Goal is vaccine that targets inflammation in joints     Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic conditions. Such stem cells, known as SMART cells (Stem cells Modified for Autonomous Regenerative Therapy), develop into cartilage cells that produce a biologic anti-inflammatory drug that, idea...
Staff Writer, TMN  Jul 23, 2018  7 years ago
Fast Facts: Kybella is a nonsurgical injection technique used to reduce excess fat beneath the chin. Each treatment takes about 15 to 20 minutes. It uses a synthetic form of deoxycholic acid. Safety:Kybella was approved by the U.S. Food and Drug Administration (FDA) in 2015. It’s a well-tolerated alternative to surgical procedures such as liposuction. Cost:One Kybella treatment costs b...
Staff Writer, TMN  Jul 22, 2018  7 years ago
CoolSculpting, or cryolipolysis, is a nonsurgical body contouring procedure. A plastic surgeon uses a device to freeze fat cells under the skin. Once the fat cells have been destroyed, they are gradually broken down and removed from the body by the liver.     Most CoolSculpting sessions take around an hour and cost about Bt 25,000 per treatment area. CoolSculping is a fairly new techniq...
Source: Zydus Cadila  Jul 19, 2018  7 years ago
Zydus Cadila gets USFDA approval for arthritis drug,Piroxicam.   Zydus Cadila has received final approval from the US health regulator for Piroxicam capsules, used for the treatment of osteoarthritis and rheumatoid arthritis. According to a BSE filing, Zydus Cadila will market Piroxicam Capsules USP in the strengths of 10 mg and 20 mg. The drug will be produced at the group’s manufa...
Source: Institute for Research in Biomedicine , Barcelona  Jul 20, 2018  7 years ago
Scientists in Spain have discovered a mechanism that promotes inflammation-related bowel cancer and could offer new treatment targets. Researchers may have found a new treatment target for bowel cancer. The finding concerns the activity of the signaling protein p38 in the myeloid cells of the immune system and that of IGF-1, which is a hormone triggered by p38.   Much of the work was con...
Source: Journal of the American College of Cardiology  Jul 20, 2018  7 years ago
Taking heart medication during chemotherapy can help minimize heart damage in breast cancer patients. A common heart medication may help minimize the toxic effects of chemotherapy, based on a clinical trial that tested the use of beta-blockers in breast cancer patients undergoing chemo. Results of the study were recently presented at the American College of Cardiology’s 67th Annual Sci...
Staff Writer, TMN  Jul 21, 2018  7 years ago
The use of permanent cosmetics dates back thousands of years in history. Microblading, a technique for creating natural looking eyebrows using pigment, has reemerged in popularity in the 21st century, and has rapidly become one of the most popular cosmetic procedures in the United States .However, it has not completely replaced traditional eyebrow micropigmentation techniques: Many peopl...
Staff Writer, TMN  Jul 20, 2018  7 years ago
One of the most promising new technologies for aesthetic treatments is the combination of two methods previously used individually for skin rejuvenation, microneedling and radiofrequency. This combination therapy, known as fractionated radiofrequency, is effective for improvement in acne and acne scars, as well as fine lines and wrinkles, both on and off the face. It can also be used for all skin ...
Staff Writer, TMN  Jul 11, 2018  7 years ago
Our Selection of the best models The world has seen so much growing sophistication in smartphones, internet services, and computers. The good news for health workers is that stethoscopes were not left out. Today, we have electronic stethoscopes.   But now that we have several companies and brands producing these techy stethoscopes, it may become a little confusing in choosing what the best ...
Source: Institute Of Medical Education and Research, India  Jul 13, 2018  7 years ago
Ashok Kumar Yadav, Ph.D., from the Postgraduate Institute of Medical Education and Research in India, and colleagues examined bone turnover among subjects who completed a randomized trial examining the effect of cholecalciferol supplementation on vascular function in patients without diabetes who had CKD stage G3-4 and vitamin D ≤20ng/ml. Participants were randomized to receive two or...
Source: European Society of Human Reproduction and Embryology  Jul 11, 2018  7 years ago
Despite many study results suggesting that antioxidants have a positive effect on abnormal sperm parameters associated with male infertility, a large US clinical trial of 174 couples has found that an antioxidant formulation taken daily by the male partner for a minimum of three months made no difference to sperm concentration, motility or morphology, nor to the rate of DNA fragmentation. Results...
Source: Bangkok Joint Congress  Jul 11, 2018  7 years ago
The Joint Congress of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology & the Asia Pacific Association of Pediatric Allergy, Respirology and Immunology is coming to the Centara Grand & Bangkok Convention Centre at CentralWorld on 11th – 14th October 2018.   With its theme “Novel Therapies, Prevention and Integrated Action: Towards Improved Patient C...
Source: Columbia University  Jul 16, 2018  7 years ago
Researchers from Columbia University have looked into the possibility of using far ultraviolet-C (far-UVC) light as a possible tool for the flu virus’s eradication.   According to the researchers, who were led by Dr. David Brenner, continuous low doses of far-UVC light can be enough to kill the airborne flu virus that has been causing problems for th...
Source: Cancer Immunology Research  Jul 13, 2018  7 years ago
A type of therapy that harnesses the immune system is giving new hope to people battling a once hopeless cancer -- melanoma that's spread to the brain.   Brain Melanoma Development New research involving more than 2,700 U.S. patients is confirming what specialists in the field have long known -- that "checkpoint blockade" treatment can beat back these ...
Staff Writer, TMN  Jul 12, 2018  7 years ago
The infection can be mistaken for chlamydia, but it's become resistant to traditional antibiotic treatments.     Doctors are warning about a sexually transmitted infection that could become the next hard-to-treat superbug, thanks to its increasing resistance to traditional antibiotics. They say that the infection, called Mycoplasma genitalium(also known as M. genital...
Source: USFDA  Jul 11, 2018  7 years ago
A new device, the Zephyr Endobronchial Valve (Zephyr Valve), has been approved by the U.S. Food and Drug Administration for the treatment of breathing difficulties associated with severe emphysema.     Valve has been approved after review of data from trial involving 190 patients with emphysema   During a procedure in a hospital setting, the Zephyr Valves are placed into the diseas...
Source: Intermountain Medical Center  Jul 16, 2018  7 years ago
A novel treatment offers kidney failure and kidney transplant patients with a rare disorder new hope. The treatment allows targeted elimination of plasma cell clones producing abnormal proteins that deposits in the kidneys and leads to kidney failure, according to new research.   This is the first time this new approach has been used successfully anywhere in the world for the disorder, known ...
Source: Loyola Medicine  Jul 13, 2018  7 years ago
Three Loyola Medicine urologists, Marcus Quek, MD, Gopal Gupta, MD, and Alex Gorbonos, MD, are co-authors of the study. First author is Dipen Parekh, MD, of the University of Miami.   Loyola is among 15 centers that participated in the nationwide trial of 350 patients, who were randomly assigned to undergo robotic surgery or open surgery to remove cancerous bladders.   A...
Source: US FDA  Jul 16, 2018  7 years ago
The U.S. Food and Drug Administration has  approved TPOXX (tecovirimat), the first drug with an indication for treatment of smallpox. Though the World Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in 1980, there have been longstanding concerns that smallpox could be used as a bioweapon.     “To address the risk of bio...
Source: USFDA  Jul 13, 2018  7 years ago
An FDA advisory committee voted to recommend approval of single-dose tafenoquine (GlaxoSmithKline) in patients 16 and older for the "radical cure" (prevention of relapse) of malaria, finding both substantial evidence for efficacy and adequate evidence for safety. The vote on the evidence for efficacy was unanimous (13-0), while the evidence for adequate safety also sailed through (12-...
Source: AbbVie Pharmaceuticals  Jul 12, 2018  7 years ago
AbbVie and Johnson & Johnson’s Imbruvica has failed to meet its key target in a late stage study assessing its use in patients with treatment-naïve diffuse large B-cell lymphoma.   The Phase III DBL3001 study did not show additional efficacy when adding Imbruvica (ibrutinib) to the existing standard of first-line care – a regimen of rituximab, cyclophosphamide, doxorubi...
Source: Phyathai 2  Jul 11, 2018  7 years ago
Phyathai 2 Hospital moves forward with their Centers of Excellence policy, invested more than 100 million baht ($3.12 million) into the Heart Center in efforts to optimize the quality of care and outfit with the most cutting edge medical technology to be the foremost cardiac treatment center in Asia.    Dr. Thouantosaporn Suwanjutah, Heart Center Director of Phyathai 2 Hospital said th...
Source: Wellcome Trusts Sanger Institute  Jul 11, 2018  7 years ago
Genetic variants can increasingly be used to connect patients to treatments as well as uncover new therapeutic targets.   Jeffrey Barrett, formerly of the Wellcome Trust Sanger Institute, described how prioritizing genome-wide association study results has uncovered drugs that could be used to treat inflammatory bowel disease.   Functional Studies on the IBD Susceptibility Gene IL23R I...
Staff Writer, TMN  Jul 14, 2018  7 years ago
Thailand's Food and Drug Administration (FDA) on Saturday issued an order to recall some batches of valsartan, a medicine used to control blood pressure and help prevent heart failure, after it was found to contain certain impurities, in doing so, Thailand joins a lists of more than 22 countries that has been doing so in the last 48 hours. The press statements was issued by Dr Wanchai Sattayaw...
Source: Johns Hopkins Medicine  Jul 10, 2018  7 years ago
In a review article published in the New England Journal of Medicine, scientist Andrew Feinberg, M.D., calls for more integration between two fields of DNA-based research: genetics and epigenetics.   Most people are familiar with genetics, a field of research that focuses on the precise sequence of chemicals that form the ladder-like structure of DNA. However, epigenetics is not as wel...
Source: Multiple  Jul 16, 2018  7 years ago
Researchers using long-read DNA sequencing have made one of the most detailed maps ever of structural variations in a cancer cell's genome. The map reveals about 20,000 structural variations, few of which have been noted before, in just one cell type associated with one form of breast cancer.     Long-read sequencing enabled the team to reconstruct in great detail the history of how...
Source: Journal Of Cell Biology  Jul 13, 2018  7 years ago
Scientists have found it challenging to understand why some breast cancers become resistant to drugs. A recent study concludes that a sticky protein might be the answer.   Fibronectin:A glue-like protein may help to explain breast cancer drug resistance. The hormone estrogen plays a vital part in the development of breast cancer. An estimated 70 percent of all bre...
Source: Nature’s Journal Of Science, doi: 10.1038/d41586-018-05573-4  Jul 12, 2018  7 years ago
Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.   Methotrexate was one of the first approved anticancer drugs, and is a cornerstone of modern chemotherapy for the treatment of certain solid tumours and blood cancers...
Source: Multiple  Jul 11, 2018  7 years ago
Abnormal accumulations of a protein called tau can collect inside neurons, forming tangled threads and eventually harming the synaptic connection between neurons. Credit: National Institute on Aging. UT Southwestern   Scientists ID genesis of disease, focus efforts on shape-shifting tau. Scientists have discovered a "Big Bang" of Alzheimer's disease – the precise point a...
Source: WHO (World Health Organisation)  Jul 11, 2018  7 years ago
The World Health Organization said Tuesday it was awaiting formal approval from the Democratic Republic of Congo to send in unlicenced Ebola medication to help rein in an outbreak of the deadly virus.   The UN health agency and DRC authorities are rushing to contain the outbreakthat has sickened 54 people in recent weeks, including 25 who have died.   A "major innovation in t...
Staff Writer, TMN  Jul 10, 2018  7 years ago
International health insurance for expats: How to choose between local insurance or an international health insurance plan. When is expat medical insurance necessary? At what point do you need to consider international health insurance? How can you choose between so many expat medical insurance plans? There are numerous factors to consider when looking to live and work abroad, n...
Source: Multiple  Jul 11, 2018  7 years ago
A new approach established at the University of Zurich sheds light on the effects of anti-cancer drugs and the defense mechanisms of cancer cells. The method makes it possible to quickly test various drugs and treatment combinations at the cellular level. Cancer cells are cells over which the human body has lost control. The fact that they are transformed body cells makes it all the more difficul...
Source: Marshall University Joan C. Edwards School of Medicine  Jul 11, 2018  7 years ago
New research from a team at the Marshall University Joan C. Edwards School of Medicine demonstrates that the Na/K-ATPase oxidant amplification loop (NAKL) is intimately involved in the aging process and may serve as a target for anti-aging interventions. The researchers were also able to successfully demonstrate the therapeutic potential of pNaKtide, a synthetic peptide, in improving impaired phys...
Source: Fierce Biotech  Jul 13, 2018  7 years ago
Scientists at UT Southwestern Medical School have spent the last two decades studying autophagy, the process cells use to throw out toxic substances that endanger their health. They discovered autophagy not only helps the body fight off infections, but it also protects against many age-related diseases such as cancer and neurological disorders. Autophagy The findings raised a question: Could b...
Staff Writer, TMN  Jul 12, 2018  7 years ago
Scientists on the hunt for anti-aging drugs say they've made an advance with tantalizing potential: Two experimental drugs appear to safely boost the immune systems of elderly humans. The researchers stress that more research is needed to confirm the findings and show the drugs are safe. And at least one researcher says the findings are based on a relatively small number of people and used m...
Source: Michigan Medicine  Jul 16, 2018  7 years ago
New Research finds that more men have suboptimal testosterone levels than previously known, and it may be putting these men at risk. Testosterone hormone replacement therapy is great tool in preventing  diseases associated with aging in men. A male’s total testosterone level may be linked to more than just sexual health and muscle mass preservation, a new study finds. Low amounts of th...
Source: multiple  Jul 10, 2018  7 years ago
More Reasons to Take Fish Oil Clinical trials have focused on the cardiovascular benefits of omega-3 fatty acids derived from fish oil.   More recent data show the biological effects that omega-3s confer extend beyond cardiovascular issues and impact virtually every aspect of our health.   A meta-analysis published last year found that the highest co...
Source: multiple  Jul 09, 2018  7 years ago
Next Frontier in Fight Against Aging As longevity scientists look to target and stop aging, many researchers are focusing on geroprotectors, compounds capable of preventing or even reversing aging at the cellular level. Senescent cells are particularly troublesome when they enter the stage in which they can no longer properly divide and function. As cells become dysfunctiona...
Source: Journal of the Endocrine Society  Jul 08, 2018  7 years ago
A new case report in the Journal of the Endocrine Society documents how a patient's use of a common biotin supplement, also known as vitamin B7, caused her to have clinically misleading test results, which prompted numerous consultations and unnecessary radiographic and laboratory testing. Maya Styner, M.D., Associate Professor, University of North Carolina School of Medicine. Cre...
Source: www.ncbi.nlm.nih.gov  Jul 07, 2018  7 years ago
New clinical study supports astaxanthin supplementation for protecting skin from damage associated with sun exposure.   A new randomized, double-blind, placebo-controlled clinical trial provides stronger evidence for the protective role of algal-derived astaxanthin against skin deterioration caused by ultraviolet (UV) light. FujiFilm’s research group conducted the resea...
Source: chalmers.se  Jul 06, 2018  7 years ago
You take supplements to stay healthy — but some of them may be doing more harm than good. Certain dietary iron supplements may aid the development of colon cancer in humans, according to new research out of Sweden’s Chalmers University of Technology.   Scientists found that two strains of iron — ferric citrate, which is found in vitamin supplements, and ferric EDT...
Source: multiple  Jul 05, 2018  7 years ago
Researchers examined brain development in babies whose mothers received folic acid supplements during the second and third trimesters of their pregnancies.   Folic acid supplements of 400 micrograms per day are recommended for women before conception and throughout the first trimester of pregnancy. This dose of folic acid is proven to prevent neural tube defects in early pregnanc...
Source: multiple  Jul 04, 2018  7 years ago
A scientific paper has revealed that some nutrients found in food may help reduce the symptoms of psychotic illness, when used in the early stages of treatment.   The systematic review, led by Dr Firth, honorary Research Fellow at The University of Manchester and Research Fellow at NICM Health Research Institute, Western Sydney University an examined if nutrient supplementation cou...
Source: multiple  Jul 03, 2018  7 years ago
A dietary supplement derived from glucose increases muscle-force production in the Duchenne muscular dystrophy (DMD) mouse model by 50% in ten days, according to a study conducted by researchers from Université Laval's Faculty of Medicine and Centre hospitalier universitaire (CHU) de Québec Research Centre-Université Laval. The results, which were recently published in the...
Source: cff.org  Jul 02, 2018  7 years ago
An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with CF.   An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis (CF), according to research published online in the American Journal of Respiratory and Critical Care Medicine.   In "Effects of an Antioxidant-Enriched Multivitamin in Cystic Fibrosis...
Source: bsmmu.edu.bd  Jul 01, 2018  7 years ago
Use of Bio-Kult led to a 69% decrease in abdominal pain, and improved Quality of Life scores.   Results of a new clinical trial confirm the use of Bio - Kult a multi-strain probiotic formula with 14 bacterial strains and 8 billion colony-forming units per day—is safe and superior to placebo in improving GI symptoms in patients with IBS-D (diarrhea-predominant irritable bowel synd...
Source: Siriraj Hospital  Jul 01, 2018  7 years ago
“We believe they will help us improve patients’ safety even further,” Dr Prof Prasit Watanapa, dean of Mahidol University’s Faculty of Medicine Siriraj Hospital, said yesterday. The hopital now serves between 8,000 and 10,000 outpatients daily. Each patient is prescribed more than one medicine on average.    The hospital’s director, Asst Prof Dr Visit Vam...

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