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COVID-19 News: The battle against Acute Lung Injury (ALI) has been a longstanding challenge for healthcare systems worldwide, and with the advent of the COVID-19 pandemic, the urgency to find effective treatments has intensified.
The detrimental effects of iron overload in the development of ALI. Overloaded iron in the lung, including alveolar epithelium and macrophages, can accelerate the pr...
COVID-19 News: Long COVID, characterized by persistent symptoms following the initial SARS-CoV-2 infection, presents a growing concern for individuals recovering from COVID-19. This study investigates the pathophysiological changes in the kidneys during long-term post-infection, focusing on fibrogenesis factors and their potential role in the development of kidney fibrosis.
Utilizing ...
U.S. Medical News: In a shocking turn of events, investigators stumbled upon an enigmatic and clandestine medical lab housed within an unassuming warehouse in Fresno, California. The discovery sent waves of concern through the local community and captured the attention of state and federal authorities. The lab was teeming with nearly 1,000 bioengineered mice and a multitude of samples harboring in...
H5N1 News: In an alarming development, South Korea has been hit by an unexpected outbreak of H5N1 Avian Influenza in cats, raising concerns among both animal lovers and health officials. The Ministry of Agriculture, Food and Rural Affairs made a startling announcement on Saturday after confirming the presence of highly pathogenic avian influenza (H5N1 type) in a cat shelter located in Gwanak-gu, S...
COVID-19 News: As Japan faces the ongoing challenges of the COVID-19 pandemic, recent data has revealed a worrisome uptick in infections. On July 28th, the Japanese Ministry of Health, Labour and Welfare disclosed crucial information regarding the country's COVID-19 situation during the week of July 17th to 23rd. The number of new COVID-19 cases reported from approximately 5,000 designated med...
Alterations in glycosylation patterns can affect virus binding efficiency, host cell entry, virus replication, and exocytosis.
COVID-19 News: In a groundbreaking research effort by AbbVie Deutschland GmbH & Co. KG, Ludwig-Maximilians-University, and the Federal Research Institute for Animal Health in Germany, a significant breakthrough has been made in understanding the pathophysiological p...
COVID-19 News - Human Intestinal miRNAs - SARS-CoV-2 Evolution Jul 30, 2023 1 year ago
The signature of SARS-CoV-2 evolution reflects selective pressures within human guts where viral persistence is an issue!
COVID-19 News: In a groundbreaking collaboration between researchers from HSE University in Moscow-Russia, Sun Yat-Sen University in Shenzhen-China, and George Mason University in Virginia-USA, a remarkable discovery has been made about the role of human intestinal mic...
U.S. Medical News - Summer COVID-19 Surge Jul 30, 2023 1 year ago
U.S. Medical News: As the summer sun shines across the United States, there's a growing concern amid a significant rise in COVID-19 hospitalizations, marking the largest percent increase since December. The latest data published by the Centers for Disease Control and Prevention (CDC) shows that weekly COVID-19 admissions have surged by more than 10% nationwide. While this wavelet is far ...
COVID-19 News: As the world yearned for an end to the COVID-19 pandemic, recent data reveals that the virus remains a looming presence, with a surge in COVID-19 cases being recorded across various geolocations in the world including Japan, South Korea, China, Australia, New Zealand, Spain and Romania.
The United Kingdom is not spared from this surge either. The latest figures from the...
COVID-19 News - Navarra - Spain Jul 30, 2023 1 year ago
COVID-19 News: As we had warned about two weeks ago about a potential rise in COVID-19 cases in Spain…Navarra, a region in Northern Spain is now witnessing an alarming rise in COVID-19 infections along with a rise in hospitalizations.
It is not just COVID-19 cases that are rising in the Northern region in Spain, but also other respiratory infections including flu, RSV and adeno...
COVID-19 News - SARS-CoV-2 Envelope Protein Mutations – Pathogenicity - Omicron XBB Jul 30, 2023 1 year ago
Study found that T9I mutation was associated with milder variants, while mutations such as P71L, correlated with more severe variants.
COVID-19 News: The emergence of various Omicron variants following the relaxation of COVID-19 restrictions raised concerns about their transmission, immune escape, and pathogenicity. Researchers from the Chinese Academy of Sciences, Shanghai, the Universit...
COVID-19 News - SARS-CoV-2 - Bacterial Co-Infections - Autoimmune Cardiopathies Jul 30, 2023 1 year ago
Research revealed that cardiac proteins and their mimics, whether from the virus or bacteria, often had complementary relationships.
COVID-19 News: As the COVID-19 pandemic swept the globe, medical researchers raced to understand the mysterious complications arising from SARS-CoV-2 infections and vaccinations. Among these perplexing phenomena were autoimmune cardiopathies (AC)- a rare but...
COVID-19 News - Genes - COVID-19-Associated Heart Failure - PYGM - BLM Jul 30, 2023 1 year ago
Scientists identify 11 genes associated with COVID-19 associate heart failure including ALPK3, RAB15, ANKRD1, XIRP2, GSG1L, PYGM, WDR62, FNDC5,BLM, LINC009 6 And ALKBH7
COVID-19 News: The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has wreaked havoc globally, leading to millions of infections and deaths. As scientists race to understand the...
COVID-19 News - Butyrate - Antiviral Properties - Reduces Oxidative Stress -Cell Survival Jul 30, 2023 1 year ago
Butyrate exhibited an effective prevention against SARS-CoV-2 by upregulating antiviral immune responses and promoting cell survival
COVID-19 News: The ongoing global battle against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seen researchers and scientists tirelessly working to develop effective therapies to combat the devastating effects of COVID-19. While various...
COVID-19 News - Terrifyingly Mutated SARS-CoV-2 Variant - 113 Mutations - Indonesia Jul 29, 2023 1 year ago
Scientists Alarmed by Record-Breaking 113 Mutations In New Variant That Has 37 Spike Mutations And Numerous Mutations In the N-Proteins!
COVID-19 News: In a shocking revelation that has sent ripples of concern across the global scientific community, a newly identified SARS-CoV-2 variant with a staggering 113 mutations has emerged in Indonesia. This mysterious strain, collected from a patien...
COVID-19 News: There are lots of Zero COVID-19 zealots out there promoting masking and a whole range of respirators, often meaning well or simply trying to get some kind of exposure in society or online to make themselves important although they have no clue about the dynamics and kinetics of the current COVID-19 situation or are they even up to date with the evolution of the SARS-CoV-2 virus.
&...
Thailand Medical - COVID-19 Infections - Adrenal Insufficiency Jul 29, 2023 1 year ago
Many Post-COVID Individuals could be suffering from hypocortisolism that is contributing to Long COVID manifestations.
Thailand Medical: In a groundbreaking study conducted by medical scientists from Chulabhorn Hospital in Thailand, a leading hospital and research center, it has been revealed that COVID-19 infections may have far-reaching consequences beyond the acute phase of the illness. The re...
COVID-19-Genetics - CD147 rs8259T>A Variant - Risk Factor - COVID-19 - Mexican Jul 29, 2023 1 year ago
COVID-19-Genetics: The coronavirus disease 2019 (COVID-19) pandemic has posed a significant global health challenge caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has become a global public health crisis, leading to millions of deaths worldwide.
The virus exhibits a wide range of clinical manifestations, from mild flu-like symptoms to severe respiratory...
COVID-19 News - Myocardial Injury - Elevated IL6 Expression - Decreased Lymphocyte Counts Jul 29, 2023 1 year ago
COVID-19 News: Since the emergence of the novel coronavirus SARS-CoV-2 in late 2019, the world has been grappling with the devastating impact of COVID-19. Among its numerous complications, myocardial injury has emerged as a serious concern, contributing to adverse outcomes and increased mortality rates.
Myocardial injury in COVID-19 patients presents a complex scenario involving exces...
Thailand Medical - lncRNAs - miRNAs - SARS-CoV-2 Jul 28, 2023 1 year ago
Thailand Medical: The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a global pandemic, leaving devastating effects on human health and economies worldwide. To combat this formidable pathogen, scientists have delved into understanding the intricate interactions between non-coding RNAs (ncRNAs) and viral infections. ...
COVID-19 News - Antiviral - Persimmon - Candies - SARS-CoV-2 Delta Jul 28, 2023 1 year ago
COVID-19 News: The ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global health crisis. One of the significant challenges in controlling the spread of the virus is its transmission through dispersed saliva. In response to this concern, researchers at Nara Medical University in Japan have been investigating the potential of per...
COVID-19 News - mRNA-1273 Vaccine-Associated Myocardial Injury Jul 28, 2023 1 year ago
Study by the University of Basel shows that one in 35 people who received the COVID-19 mRNA booster vaccinations had vaccine-associated myocardial injury!
COVID-19 News: The COVID-19 pandemic brought the world to a standstill, and the development of vaccines became a global priority to combat the deadly virus. Among these vaccines, the mRNA-based ones, such as the mRNA-1273 vaccine, has b...
COVID-19-News - Diabetic-Ketoacidosis Jul 28, 2023 1 year ago
African Study Showed Alarming Rise In The Life Threatening Condition Of Diabetic Ketoacidosis As A Result Of COVID-19 Surges
COVID-19 News: The COVID-19 pandemic has swept across the world, leaving devastation in its wake. Not only has it affected millions of lives directly through infection, but it has also had far-reaching consequences on various health conditions. One alarming concern th...
COVID-19 News - Neural Autoantibodies - Psychiatric Symptoms - COVID-19 And Post-COVID Jul 28, 2023 1 year ago
The study also raised concerns about potential brain damage in patients with autoantibody-associated COVID-19 and Long COVID.
COVID-19 News: A new study conducted at the University Medical Center Göttingen, Germany, has revealed a startling connection between neural autoantibodies and psychiatric symptoms in patients affected by SARS-CoV-2 infection. The study delved into the phenomeno...
COVID-19 News - Mild COVID-19 Infections - Hepatitis B Virus (HBV) Reactivation Jul 27, 2023 1 year ago
More reported cases of Hepatitis B activation in COVID-19 patients and Post COVID individuals are raising alarms!
COVID-19 News: The COVID-19 pandemic that emerged in late 2019 has proven to be a global public health crisis, affecting millions of people worldwide. While the primary impact of the virus is on the respiratory system, researchers have also observed its effect on other organs, i...
COVID-19 News - Cytolytic CD8+ T Cell Response - Severe COVID-19 Jul 27, 2023 1 year ago
It was found that severe disease patients had higher numbers of SARS-CoV-2 reactive CD8+ T cells with cytolytic function and the ability to produce inflammatory cytokines simultaneously.
COVID-19 News: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide, with a wide range of clinical manifestations, from mild cases to severe illness and even fatalities...
COVID-19-Drugs - N-Acetylcysteine - Sulodexide Jul 27, 2023 1 year ago
Study Finds That Both N-Acetylcysteine And Sulodexide Has Protective Properties On Endothelial Cells After SARS-CoV-2 Infection
COVID-19 Drugs: The world was taken by storm when the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged, causing the coronavirus disease 2019 (COVID-19) pandemic. Beyond its devastating impact on the respiratory system, this novel virus also wrea...
COVID-19 News - Hyperendemic Jul 27, 2023 1 year ago
Various SARS-CoV-2 sub-lineages are prevalent across various geolocations literally everywhere across the world but most are causing asymptomatic infections initially!
COVID-19 News: Many of you might be confused as to why governments around the world are trying to play down the ongoing COVID-19 situation and also as to why they are relaxing all measures despite stories of people still gett...
Medical News - Drug News - Metformin - Muscle Atrophy Jul 26, 2023 1 year ago
Study found that metformin helps muscle cells better remodel and repair tissue during periods of recovery after inactivity.
Drug News: When you hear about diabetes medications, muscle function might not be the first thing that comes to mind. However, groundbreaking research from the University of Utah Health has revealed that the common diabetes drug, Metformin, has unexpected applic...
COVID-19-Pregnancy - Lipid Metabolism - Newborn Health Jul 26, 2023 1 year ago
Some of these lipid metabolism disruptions can result in non-proper brain development of the newborns, auto-immune and inflammatory issues!
COVID-19-Pregnancy: This is our 7th installment of a series of 25 articles as to why couples should not conceive while the COVID-19 crisis is still ongoing. The links to the previous 6 articles can be found at the end of the article.
The COVID-1...
COVID-19 News - BA.5 sub-lineages Jul 26, 2023 1 year ago
BA.5 sub-lineages like BA.5.2, BA.5.2.1, BA.5.2.6, BF.7.15 and BF.7.4.1 are causing the rise in COVID-19 hospitalizations not the XBB variants or EG.5.2
COVID-19 News: Contrary to misconceptions that perhaps some new XBB sublineages such as EG.5.1 etc could be driving disease severity and also COVID-19 hospitalizations in Japan, China and South Korea, the actual SARS-CoV-2 sub-lineages causing th...
MERS News - New Mers Variant Jul 26, 2023 1 year ago
THE MERS coronavirus could have mutated to give rise to new variants that are better for human-to-human and airborne transmissions. Studies currently underway.
MERS News: The recent media frenzy about the isolated case of a 28-year-old man in the Al Ain city in Abu Dhabi-UAE who contracted the MERS coronavirus and is currently in the ICU in a hospital fighting for his life is not only baffl...
COVID-19 News: Total Deaths In the UK For the Week Ending 14 of July Has Increased to 10,030 Deaths!
Latest released data from the ONS in UK shows that there were 10,030 deaths were registered in England and Wales in the week ending 14 July 2023 (Week 28).
This represents 4.2% above the five-year average. While the total deaths increased, COVID-19 deaths were also rising in parallel....
SARS-CoV-2 News - SARS-CoV-2 Y505H Spike Mutation - ACE2 - NRP1 Receptors Jul 25, 2023 1 year ago
Pakistani study reveals that I210T, V213G, S371F, S373P, T478K, F486V, Y505, D796Y mutations enhances SARS-CoV-2 binding with ACE2 and NRP1 and enhances viral transmission.
SARS-CoV-2 News: Since the emergence of SARS-CoV-2 in late 2019, the world has been grappling with an unprecedented global health crisis. The virus responsible for COVID-19 has rapidly spread across...
COVID-19 News - SARS-CoV-2 NSP3 Protein - The Macro1 Domain - Innate Immunity Jul 25, 2023 1 year ago
The study finding shed light on the importance of the Macro1 domain in SARS-CoV-2 and its potential as a target for antiviral drug design
COVID-19 News: In the quest to better understand the notorious SARS-CoV-2 virus responsible for the COVID-19 pandemic, French researchers from Aix Marseille Université, CNRS have made a remarkable discovery. Their focus was on a critical protein calle...
COVID-19 News - Plasma Metabolome - Severe And Fatal COVID-19 Cases Jul 25, 2023 1 year ago
Study found that choline-related metabolites, serine, glycine, and betaine, were reduced in severe COVID-19, as a result of dysregulation in methyl donors. Non-survivors had higher levels of creatine/creatinine,4-hydroxyproline, gluconic acid, and N-acetylserine, indicating liver and kidney dysfunction.
COVID-19 News: The COVID-19 pandemic has cast its long shadow across the world, and Braz...
COVID-19 News - SARS-CoV-2 Infections - Pancytopenia Jul 24, 2023 1 year ago
Pancytopenia occurs when an individual's blood shows unusually reduced levels of all three types of blood cells - red blood cells, white blood cells, and platelets.
COVID-19 News: In the ongoing battle against the COVID-19 pandemic, medical experts have recently issued a warning regarding a rare but concerning complication associated with the SARS-CoV-2 virus. This complication, known as Panc...
COVID-19 News – SARS-CoV-2 Nonstructural Protein 6 - NSP6 Jul 24, 2023 1 year ago
COVID-19 News: Since its first appearance in late 2019, the SARS-CoV-2 virus has embarked on a relentless evolutionary journey, presenting humanity with an ever-changing array of variants and challenges. As the virus adapts and mutates, it raises concerns about vaccine efficacy, therapeutic strategies, and the potential for new waves of infections. Among the enigmatic components influencing the be...
COVID-19 News - N-Acetyl Cysteine - Conformational Perturbation - SARS-CoV-2 Spike Protein Jul 23, 2023 1 year ago
N-acetyl cysteine can inhibit SARS-CoV-2 and ACE-2 Binding by increasing the probability of structural deformation of the viral spike protein
COVID-19 News: The ongoing SARS-CoV-2 pandemic has wreaked havoc across the globe, leaving behind devastating consequences for public health and economies alike. As researchers and medical professionals tirelessly search for effective therapeutic inte...
Thailand Medical - L-Carnitine L-Tartrate - Beneficial Coagulation Modulating Effects - COVID-19 Individuals Jul 23, 2023 1 year ago
L-Carnitine L-Tartrate supplementation led to an increase in platelet levels and decrease in fibrinogen levels, displaying an antithrombotic effect, which could be beneficial in reducing thrombosis-induced complications in COVID-19 individuals.
COVID-19 Supplements: In a new medical discovery, researchers from multiple prestigious institutions in Brazil have unveiled the potential beneficia...
COVID-19-News - SARS-CoV-2 Accessory Proteins ORF6, ORF8, ORF9b, ORF9c - Inflammatory And Profibrotic Processes - IL11 Signaling Jul 23, 2023 1 year ago
Of all, ORF9b showed a greater effect in extracellular matrix remodeling. Interestingly, increased IL11 also led to ECM remodeling
COVID-19 News: The SARS-CoV-2 virus carries eleven enigmatic accessory proteins encoded within its genome. Scientists have long sought to understand the roles of these proteins during infection, and a groundbreaking study has shed light on their involvement in t...
COVID-19 News - 17 Percent Of Post COVID Individuals - Cognitive Issues Recovered - 38 Weeks Jul 22, 2023 1 year ago
With billions already exposed to SARS-CoV-2 and millions more getting reinfected often, the global scenario is simply frightening!
COVID-19 News: As the world grapples with the ongoing COVID-19 pandemic, new research from King's College London has shed light on a concerning aspect of the virus's impact on individuals' cognitive abilities. The study, conducted between July 2021 a...
COVID-19 News - COVID-19 Causes Changes In Phosphocalcium Metabolism Jul 22, 2023 1 year ago
Many Post COVID Individuals will suffer from phosphocalcium metabolism disorders including hypophosphatemia, hypocalcemia, and secondary hypoparathyroidism.
COVID-19 News: The COVID-19 pandemic has not only affected the respiratory system but has also shown to have far-reaching systemic effects. A fascinating new study conducted by researchers from various esteemed institutions in Romania...
COVID-19 News - SARS-CoV-2 Nucleocapsid 203K/204R Mutations - Inflammatory Response Jul 22, 2023 1 year ago
COVID-19 News: In the twenty-first century, humanity has faced one of its greatest challenges in the form of the COVID-19 pandemic. Ever since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, the virus has wreaked havoc worldwide, causing millions of deaths and disrupting lives in unimaginable way as reported in various past COVID-19 News reports. As ...
COVID-19 Immunology - T Cell Receptor Signatures - COVID-19 Severity Jul 22, 2023 1 year ago
While most COVID-19 patients exhibited reduced TCR clone diversity, those with severe disease had a significant increase in the overall abundance of dominant T cell clones, indicating clonal expansion and enrichment of specific TCR clones
COVID-19 Immunology: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has left an indelible mark on humanity, claiming millions of lives...
Long COVID - Two Major Types Of Antiviral Immune Responses Jul 22, 2023 1 year ago
Divergent Adaptive Immune Responses Define Two Types Of Long COVID
Long COVID, the persistent set of symptoms experienced by some patients following a SARS-CoV-2 infection, has remained a perplexing and poorly understood condition. Researchers from the Université de Paris Cité-France, Hôtel Dieu Hospital-France, Institut Pasteur-France, and INSERM-France have recently sh...
COVID-19 Drugs - Prophylactic - Emerging SARS-CoV-2 Sublineages Jul 21, 2023 1 year ago
Thailand Medical News Exclusive: An existing approved generic drug with an already proven safety track record could be used as a prophylactic and also therapeutic drug against SARS-CoV-2.
COVID-19 Drugs: While new COVID-19 surges are once again wreaking havoc in countries like Japan, South Korea, parts of Brazil and also China, and also in Australia and New Zealand, COVID-19 cases are also ...
COVID-19 -News - SARS-CoV-2 - Oral Cavity - Trypsin-Like Proteases - Anaerobic Bacteria Jul 21, 2023 1 year ago
Daily oral hygiene and reducing components derived from oral indigenous bacteria will help prevent SARS-CoV-2 infection
COVID-19 News: In the ongoing battle against COVID-19, scientists have been relentlessly seeking to understand how the SARS-CoV-2 virus operates within the human body.
A recent groundbreaking study conducted by researchers from the Osaka Institute of Public Health...
COVID-19 News - Anti-Glycan Antibodies - ADE - SARS-CoV-2 Infections Jul 21, 2023 1 year ago
Role of anti-glycan antibodies and viral glycosylation in COVID-19 pathogenesis warrants further detailed investigation.
COVID-19 News: Antibody-dependent enhancement (ADE) is a puzzling phenomenon in which virus-specific antibodies paradoxically exacerbate viral replication and immune responses, leading to severe infection outcomes. ADE has been observed in various viral infections, includ...
COVID-19-Genetics - Genes FYCO1, LZTFL1, XCR1, CCR9, TMLHE-AS1, SCYL2 -COVID-19 Severity Jul 20, 2023 1 year ago
The study found the six genes at locus 3p21.31 significantly associated with severe COVID-19
COVID-19-Genetics: Severe COVID-19, caused by SARS-CoV-2, presents a diverse clinical profile with underlying genetic factors playing a crucial role in disease severity. In this captivating study, researchers from the Federal Medical Biological Agency in Moscow, Russia, explore the genetic predisp...
COVID-19 News - SARS-CoV-2 Infects Liver Cells Or Hepatocytes -Hyperglycemia Jul 20, 2023 1 year ago
SARS-CoV-2 is capable of infecting hepatocytes using GRP78 and ACE2 receptors and stimulate these cells to produce glucose through gluconeogenesis
COVID-19 News: The COVID-19 pandemic has been an unprecedented global health crisis, affecting millions of lives worldwide. One of the concerning complications associated with this viral infection is hyperglycemia, a condition characterized by ...
SARS-CoV-2 Is Now Evolving To ‘Out’ Governments That Have Been Trying To Conceal Its Threat By Further Driving Disease Severity That Cannot Be Kept Hidden!
COVID-19 News: Researchers and scientist are sounding warnings that urgent studies are needed on the emerging SARS-CoV-2 sub-lineages that are currently circulating in Japan that are not only driving a surge in COVID-19 inf...
COVID-19 News - SARS-CoV-2 Evades CD4+ T Cell Immunity - HLA Class II-Presented Epitopes Jul 20, 2023 1 year ago
Specifically, the Omicron variant of SARS-CoV-2 was found to escape pre-existing immune memory to two epitopes through two distinct mechanisms.
COVID-19 News: The ongoing battle against the COVID-19 pandemic relies not only on vaccines and antibodies but also on the critical role played by CD4+ T cells in providing long-lasting immunity. These T cells recognize specific peptide epitopes of the ...
COVID-19 News - Allele HLA-B*15:01 - Asymptomatic SARS-CoV-2 Infection Jul 19, 2023 1 year ago
COVID-19 News: In a groundbreaking discovery, scientists from the University of California, San Francisco and La Trobe University in Australia have found a genetic link between the allele HLA-B*15:01 and asymptomatic infection with the SARS-CoV-2 virus.
This study finding sheds new light on the immunological features that promote rapid viral clearance and could have significant implic...
SARS-CoV-2-Research - Short Sequence Motifs - PDZ Domain - Host Cell Polarity Signaling Jul 19, 2023 1 year ago
Understanding How SARS-CoV-2 Also Indulges In Manipulating Cell Polarity Signaling Using E proteins Will Give Us Better Insights Into Its Pathogenesis
SARS-CoV-2 Research: Cell polarity, the asymmetrical distribution of molecules within a cell, is crucial for proper tissue development and function. It guides essential cellular processes such as cell division, migration, and neuronal signa...