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Long COVID - Diminished Peripheral CD8+β7 Integrin+ T Cells Mar 31, 2023 2 years ago
Long COVID: A new study led by researcher from University of Minho, Braga-Portugal and Hospital of Braga-Portugal has found that diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response characterizes Long COVID.
It has been estimated that several millions of individuals worldwide are likely to experience Long COVID, a condition that continues to affect patients...
COVID-19 News - SARS-CoV-2 Spike Protein Activates the EGFR Or Epidermal Growth Factor Receptor-Mediated Signaling Mar 31, 2023 2 years ago
COVID-19 News: Scientists from United Arab Emirates University-UAE have in a new study shockingly found that the SARS-CoV-2 spike 1 proteins are able to activate the EGFR or Epidermal Growth Factor Receptor-mediated signaling.
Image Credit: Kateryna Kon/Shutterstock
The study findings has numerous implications in both pathogenesis of SARS-CoV-2 and also in Post COVID dangers.
The ongoing...
Fumarate Hydratase -COVID-19, Sepsis, Lupus, Arthritis Mar 30, 2023 2 years ago
Fumarate Hydratase: In an effort to understand the progression of inflammatory diseases, researchers at the Trinity Biomedical Sciences Institute's School of Biochemistry and Immunology in Trinity College Dublin have made a significant breakthrough. This new understanding reveals a potential therapeutic target for a variety of inflammatory conditions.
The team found that an enzyme cal...
COVID-19 News - Red Blood Cells Play A Role In Multi-Organ Spread of SARS-CoV-2 Mar 30, 2023 2 years ago
COVID-19 News: A new study led by researchers from Universidad de Buenos Aires-Argentina involving a MHV murine model has found that that red blood cells play a role in multi-organ spread of SARS-CoV-2.
COVID-19 is a complex disease that affects various organs beyond the respiratory system. While hematological disorders are commonly associated with the disease, the mechanism of SARS-CoV-2...
COVID-19 News : Resistance To Clinical Protease Inhibitors Mar 30, 2023 2 years ago
COVID-19 News: Research led by scientist from the University of Minnesota-USA has found that the SARS-CoV-2 coronavirus is evolving to escape all known clinical protease inhibitors. As drug resistance becomes a major issue in the coming CVID-19 onslaughts, a strategy of using a combination of antivirals like that in HIV treatment protocols might be a better solution.
The study also compri...
COVID-19 News - XBC.1.6 - South Australia Mar 30, 2023 2 years ago
COVID-19 News: Daily COVID-19 infections are rising once again in the state of South Australia that has a population of about 1.77 million individuals.
In the week ending 24th of March 2023, there was 2,888 officially reported new COVID-19 infections out of about 8750 PCR tests conducted.
https://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/conditions/infectiou...
COVID-19 News - mRNA Shots -IgG4 Mar 29, 2023 2 years ago
COVID-19 News: A new international study has found that IgG4 antibodies produced by mRNA shots generate immune tolerance to SARS-CoV-2’s spike protein by immune system suppression.
Spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination.
Image Credit: Juan Gaertner/Shutterstock
As a result of the health crisis caused by SARS-CoV-2, the creation of a new vaccine platform ...
COVID-19 News - ORF6 - ORF8 - ORF9b - ORF9c - Profibrotic Processes Mar 29, 2023 2 years ago
COVID-19 News: A new study by Spanish researchers from Margarita Salas Center for Biological Research (CIB-CSIC),Madrid, University of Córdoba, Biomedical Research Institute of Córdoba (IMIBIC), National Centre for Biotechnology (CNB-CSIC), Institute for Health Research Hospital ‘12 de 16 Octubre’ (imas12) and the Centre for Biomedical Research Network on Infe...
COVID-19 News - SARS-CoV-2 Evolving To Evade T Cells Mar 29, 2023 2 years ago
COVID-19 News: In the course of the COVID-19 pandemic, we have seen the SARS-CoV-2 virus constantly evolving and spawning newer variants and sub-lineages and, in some cases, even recombining to evade the various antibodies induced by the vaccines or even by the previous infections. The various monoclonal based therapeutics and convalescent plasma protocols are no longer effective to deal with the ...
Clinical Practice - Hydrocortisone And Fludrocortisone - Sepsis Mar 28, 2023 2 years ago
Clinical Practice: A new study by researchers from the Boston University Chobanian & Avedisian School of Medicine-USA, University of Toronto-Canada has found that a combination of hydrocortisone and fludrocortisone is better at treating septic shock.
The study findings are of relevance in this COVID-19 era where it has been found that many hospitalized COVID-19 with disease severity o...
COVID-19 News - XBB.1.16 - Singapore Mar 28, 2023 2 years ago
COVID-19 News: The Ministry of Health (MOH) of Singapore has stated that the recent surge in COVID-19 cases is not putting undue strain on the nation's healthcare capacity. The ministry was responding to queries from CNA on Monday, March 27th.
https://www.channelnewsasia.com/singapore/singapore-covid-19-cases-increase-not-strain-healthcare-capacity-mom-3376686
According to Singapore&r...
Outbreak News - H3N8 Equine-Avian Flu - China Mar 28, 2023 2 years ago
Outbreak News: A 56-year-old woman in Zhongshan City, Guangdong province, China has tested positive for the H3N8 equine/avian influenza virus, marking only the third time the virus has been detected in humans.
The woman, who has multiple myeloma and other underlying health conditions, had exposure to live poultry and wild birds in the vicinity of her home before falling ill.
The H3...
COVID-19 News - Neurodevelopmental Disorders In Babies Mar 28, 2023 2 years ago
COVID-19 News: During the first year of the COVID-19 pandemic, we had lots of so called medical ‘experts’ and health authorities who made claims publicly that the SARS-CoV-2 coronavirus does not affect unborn babies or even infants and that it was of no threat to pregnant mothers.
Pic Credit: Bill O’Leary/Washington Post via Getty Images
Past forward, three years later and we ...
COVID-19 News - Hair Loss - Growth Arrest-Specific 6 -Gas6 Mar 27, 2023 2 years ago
COVID-19 News: A new study by researchers from Università del Piemonte Orientale (UPO)-Italy, A.O.U. Maggiore della Carità-Italy, Ospedale Alessandria-Italy and University of Trieste-Italy has found that decreased growth arrest-specific 6 (gas6) and sAxl plasma levels are associated with hair loss in COVID-19 survivors.
Post-acute symptoms following COVID-19 are quite common...
COVID-19 News : Vogt-Koyanagi-Harada Syndrome Mar 27, 2023 2 years ago
COVID-19 News: A new study cum case report by physicians from the Department of Neurology, Miller School of Medicine, The University of Miami, Florida-USA has shocking found that SARS-CoV-2 Infections can lead to Vogt-Koyanagi-Harada Syndrome and total blindness! It is not known at this stage if the condition is caused by specific SARS-Cov-2 sub-lineages and if so which ones.
Vogt-Koyanag...
Long COVID News - Pregnenolone Mar 26, 2023 2 years ago
Long COVID News: Thailand Medical News strongly advocates that more research is conducted with regards to supplementation with the hormone pregnenolone to help with certain Long COVID manifestations as we strongly feel that it can help with fatigue, cognitive issues and many other symptoms seen in Long COVID.
Long COVID, also referred to as post-acute sequelae of SARS-CoV-2 infection (PASC), has ...
COVID-19 News - XBB.1.1 6- India Mar 26, 2023 2 years ago
COVID-19 News: As COVID-19 continues to evolve, a new variant, XBB.1.16, is raising concerns in India. The country has reported at least 344 XBB.1.16 sequences isolated by India's Sars-CoV-2 genome sequencing consortium INSACOG, accounting for 49% of the global database GISAID's XBB.1.16 sequences.
The variant has been found in samples of all six sates states witnessing a rise in ...
UK Medical News - COVID-19 Cases Rising Mar 26, 2023 2 years ago
UK Medical News: COVID-19 cases in the United Kingdom have climbed to their highest levels since the beginning of the year, with an estimated 1.7 million people in private households likely to have had the virus in the week ending 13 March according to the last ONS (Office for National Statistics) COVID-19 infection survey report.
https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocial...
COVID-19 Immunology - Damage Of Innate And Adaptive Immune System Mar 25, 2023 2 years ago
COVID-19 Immunology: This is a summarized overview for readers to comprehend how SARS-CoV-2 Infections damages both the Innate and Adaptive components of the human host immune system based on 27 selected studies that Thailand Medical News selected.
Comprehending the immune damage mechanisms provide essential guidelines for clinical treatment and immune prevention strategies. Numerous stud...
COVID-19 News - OAS Genes - Heart Failure Mar 24, 2023 2 years ago
COVID-19 News: COVID-19, the ongoing global pandemic caused by the SARS-CoV-2 virus, has been shown to not only cause severe respiratory illness but also damage multiple organs, particularly the heart. This can lead to myocardial injury, heart failure (HF), and even cardiac death.
Heart failure is the fourth most common complication of COVID-19, and it is also the final outcome of numerou...
COVID-19 News - SARS-CoV-2 - Microglial Purinergic Signaling Mar 24, 2023 2 years ago
COVID-19 News: Researchers from Universidade Federal do Rio de Janeiro-Brazil have in a new study discovered that SARS-CoV-2 spike protein alters microglial purinergic signaling! The study findings have numerous worrisome implications in terms of the long-term health and medical issues that many Post COVID individuals will ultimately develop.
Despite long-term sequelae of COVID-19 emergin...
COVID-19 News - Proteinuria Mar 24, 2023 2 years ago
COVID-19 News: A new study led by researchers from Rush University Medical Center, Chicago-USA has found that non-Omicron variants more likely to cause damage to the kidney's filtration system than Omicron sub-lineages.
The study team also comprised of scientists from Tulane National Primate Research Center-USA, University Medicine Greifswald-Germany, NIPOKA GmbH-Germany, Morphic Ther...
COVID-19- News - CD8 T Cells Mar 23, 2023 2 years ago
COVID-19 News: A new study led by researchers from Stanford University has found that prior SARS-CoV-2 infections can diminish CD8+ T cell activation and expansion in individuals receiving the COVID-19 vaccinations.
The study team conducted the study using spheromers to identify dominant T cell epitopes in response to the Pfizer/BioNTech BNT162b2 mRNA COVID-19 vaccine.
T cells play...
COVID-19 Herbs - Curcumin Mar 23, 2023 2 years ago
COVID-19 Herbs: A randomized controlled clinical trial conducted by researchers from Arizona State University has demonstrated that the herbal phytochemical curcumin offers anti-inflammatory benefits for adults recovering from COVID-19 and were vaccinated.
The protection provided by COVID-19 infection and vaccination varies against reinfection and breakthrough infection. The study team aimed to...
COVID-19 Drugs - Tucaresol Mar 23, 2023 2 years ago
COVID-19 Drugs: Tucaresol, an is an orally administered antisickling agent which increases the oxygen affinity of hemoglobin is emerging as a potential COVID-19 antiviral and drug to treat SARS-CoV-2 induced lymphopenia and immunodeficiency according to researchers from ChemThera Sciences, a pharmaceutical research company based in Montreal, Canada with a branch in Delaware, United States.
 ...
COVID-19 News - Monocyte-Derived Macrophages - Vascular and Lung Damage Mar 23, 2023 2 years ago
COVID-19 News: A new study lead by researchers from the Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Germany haas found that monocyte-derived macrophages in SARS-CoV-2 infection causes vascular and lung damage in hamsters.
Credit: SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY / Getty Images
The innate immune response plays a crucial role in how the...
COVID-19 News - SARS-CoV-2 Binds To Hemoglobin Mar 22, 2023 2 years ago
COVID-19 News: Researchers from the Bulgarian Academy of Sciences (BAS)-Bulgaria, National Center of Infectious and Parasitic Diseases- Bulgaria and Université du Québec en Outaouais-Canada in a news study using surface plasmon resonance (SPR) and double resonance long period grating (DR LPG) techniques have validated that SARS-CoV-2 structural proteins binds to hemoglobin and myoglo...
COVID-19 Supplements - Folic Acid (Vitamin B9) Mar 22, 2023 2 years ago
COVID-19 Supplements: A new study review by researchers from the University of Thessaly, Biopolis-Greece poses the warning that folic acid levels in an individual can determine the direction of the disease progression of a SARS-CoV-2 infection and even the risk of mortality, and that further studies are needed to discover what is the optimal range of physiological levels dosing to reap the protect...
COVID-19 News - SARS-CoV-2 Activates Endogenous Retroviruses Mar 22, 2023 2 years ago
COVID-19 News: Scientists from the Institute for Stem Cell Science and Regenerative Medicine, Bangalore-India, Institute for Medical Virology and Epidemiology of Viral Diseases at the University Hospital Tübingen-Germany, Department of Molecular Biology and Genetics at Cornell University-USA and the German Center for Neurodegenerative Diseases (DZNE)-Germany have in a new study found that SAR...
COVID-19 Drugs - Chlorpromazine And Prochlorperazine Mar 21, 2023 2 years ago
COVID-19 Drugs: Indian researchers after conducting successful animal model drug trials involving hamsters are suggesting that G4-binding drugs, chlorpromazine and prochlorperazine could be repurposed against SARS-CoV-2 infections.
Chlorpromazine, marketed under the brand names Thorazine and Largactil among others, is an antipsychotic oral medication. It is primarily used to treat psychot...
COVID-19 News - Metabolic Alterations -170 Dysregulations Mar 21, 2023 2 years ago
COVID-19 News: A new study by researchers from University of Zacatecas-Mexico, Instituto Mexicano del Seguro Social-Mexico, Waters Technologies of Brazil, Waters Corporation-Mexico and University of Monterrey-Mexico has alarmingly found that up to 170 metabolic dysregulations were found in recovered SARS-CoV-2 patients two years on….. especially dysregulated lipid pathways.
Accordi...
Long COVID News - Breathing Issues Mar 21, 2023 2 years ago
Long COVID News: A new study by researchers from Stanford University School of Medicine has found the mechanism that may explain one of the most prevalent symptoms of Long COVID - breathing difficulties. These post-COVID-19 respiratory issues are the result of a condition called lung fibrosis, which occurs when damaged lung tissue forms scars, making it challenging for the lungs to expand and cont...
COVID-19 News - Obesity - Weakened Immune Response in COVID-19 Mar 20, 2023 2 years ago
COVID-19 News: A new study led by researchers from University of Cambridge-United Kingdom has found that obesity linked to weakened immune response in COVID-19 patients, often leading to disease severity.
The study was included scientists from Wellcome Sanger Institute-United Kingdom, Shenzhen Third People’s Hospital-China, University College London-United Kingdom, Newcastle Univers...
COVID-19 News - Variety Of XBB Sublineages Driving COVID-19 Onslaught In India Mar 20, 2023 2 years ago
COVID-19 News: Indian Health authorities reported a mere 918 COVID-19 Infections, and only 3 COVID-19 deaths in the last 24 hours casting doubt on the reliability of such official figures!
https://www.mohfw.gov.in/
Doctors and hospitals in the state of Maharashtra and Gujerat are witnessing a high rise in hospitalizations due to COVID-19 and outpatient clinics are literally being outrun b...
Long COVID News - T Cell Dysregulation Mar 20, 2023 2 years ago
Long COVID-19 News: A new study by researchers from University of California, San Francisco-USA, Ulm University Medical Center-Germany, Zuckerberg San Francisco General Hospital-USA has found that T Cell dysregulation, uncoordinated adaptive immune response to SARS-CoV-2 along with inflammation are among the many factors behind Long COVID!
The study investigated the role of T-cells in Lon...
COVID-19 News: Taiwan's Central Epidemic Command Center (CECC) announced on Sunday 8,419 new COVID-19 cases and 43 COVID-19 deaths, marking a 7.4 percent decrease in local infections from the previous week. With this update, the total number of COVID-19 infections in Taiwan since the start of the pandemic in early 2020 has reached 10,231,343, accompanied by 18,775 deaths.
Pic Credit: Getty
&...
SARS-CoV-2 And Human Growth Hormone Mar 19, 2023 2 years ago
Human Growth Hormone or HGH is now emerging as interesting therapeutic agent that can prevent disease severity and also help with Long COVID issues. In fact emerging data also shows that it can also be deployed as a potential prophylactic agent to prevent SARS-CoV-2 infections!
Thailand Medical News found in preliminary meta-analysis of published studies that many infected and hospitalize...
COVID-19 News - SARS-CoV-2 E Proteins - Pyroptosis Mar 19, 2023 2 years ago
COVID-19 News: A new study by researchers from Nanchang University-China, The Second Affiliated Hospital of Nanchang-China, Hainan General Hospital-China and University of Missouri Kansas City-USA has found that the SARS-CoV-2 E protein induces inflammatory response and monocyte pyroptosis which can be reversed by Ruscogenin.
Ruscogenin is an anti-inflammatory steroid and is actually a phytochem...
SARS-CoV-2 Research - Metalloproteinases, Specifically MMP-2 and MMP-9, For Viral Entry Mar 19, 2023 2 years ago
SARS-CoV-2 Research: Scientists from University of Ottawa-Canada, Western University-Canada and University of Western Ontario-Canada have in December 2022 found that SARS-CoV-2 can also use Metalloproteinases, specifically MMP-2 and MMP-9, for viral entry and also for cell fusion.
 ...
COVID-19 Supplements - Vitamin K - Ferroptosis Mar 18, 2023 2 years ago
COVID-19 Supplements: Researchers from the Department of Medical Biology and Biochemistry, Faculty of Medicine, Nicolaus Copernicus University in Toruń-Poland have conducted a study review examining the potential of Vitamin K in suppressing SARS-CoV-2 induced ferroptosis. Ferroptosis, a recently identified form of programmed cell death, is characterized by the accumulation of iron and lipid hydrop...
SARS-CoV-2 Research - Fusion Peptide Mar 18, 2023 2 years ago
A new study by researchers from the Institute of Research, Development, and Innovation in Healthcare Biotechnology (IDiBE), Universitas “Miguel Hernández”, Spain has found that SARS-CoV-2 spike’s fusion peptide binds to negatively-charged phospholipids in cell membranes of host without significant changes to its secondary structures.
The SARS-CoV-2 virus which causes the...
COVID-19 News -SARS-CoV-2 Infections Rising Again Mar 18, 2023 2 years ago
COVID-19 News: In the last 36 hours, the WHO had once again opened their mouths prematurely and said that the threat from COVID-19 would likely be reduced and be on par with that of flu and that the agency will likely be able to declare an end to the health emergency sometime in 2023.
https://www.voanews.com/a/who-sees-covid-posing-similar-threat-to-flu-this-year-/7010599.html
Interesting...
COVID-19 Research - 1,449 Human Host Plasma Proteins Altered By SARS-CoV-2 Mar 17, 2023 2 years ago
COVID-19 Research: Researchers from Washington University School of Medicine, St Louis, Missouri-USA have in a new study utilizing detailed proteomics discovered that over 1,449 Human Host proteins including critical genes, enzymes and cellular proteases necessary for various cellular functions are altered (damaged, dysregulated or suppressed) by SARS-CoV-2 infections!
Identification of p...
Long COVID News - Decreased Plasma Tryptophan - Increased Kynurenine Levels Mar 17, 2023 2 years ago
LONG COVID News: A new study by researchers based in Iraq and Thailand has found that decreased plasma Tryptophan and increased Kynurenine levels may be contributing factors to Long COVID symptoms.
Already, severe cases of COVID-19 have been linked to reduced levels of tryptophan (TRY) in the blood and an increase in indoleamine-dioxygenase (IDO)-triggered production of neuroactive trypto...
COVID-19 News - Acute Necrotizing Encephalopathy - Infants Mar 17, 2023 2 years ago
COVID-19 News: Chinese pediatricians and scientists from Guangxi Maternal and Child Health Hospital have reported the first documented case of a 45-day infant developing acute necrotizing encephalopathy (ANE) as a result of SARS-CoV-2. Although this is the first case documented of acute necrotizing encephalopathy in an infant, local physicians are questioning if there are any new changes in the pa...
COVID-19 News - Omicron Not Mild In Children Mar 17, 2023 2 years ago
COVID-19 News: A new study involving 14 Canadian pediatric Emergency Departments (ED) in hospitals across the country has found that the SARS-CoV-2 Omicron is causing more health issues in children that previously thought.
Pic Credit: Evgeniy Shkolenko / iStock
The stud team aimed to investigate the differences in symptoms, chest X-ray results, treatments, and outcomes among children infe...
COVID-19 Research: Alterations In Gut Immunological Barrier Mar 16, 2023 2 years ago
COVID-19 Research: A new study by researchers from University of Patras-Greecee, University Hospital of Patras-Greece and “Agios Andreas” Patras State General Hospital-Greece has found that SARS-CoV-2 infections causes alterations in gut immunological barrier.
Key features of intestinal immune barrier disruption during SARS-CoV-2 infection. SARS-CoV-2 infection is associated with pro...
COVID-19 News -CIART -SARS-CoV-2 Mar 16, 2023 2 years ago
COVID-19 News: A new study led by scientists from Weill Cornell Medicine, New York-USA had identified CIART, the circadian-associated repressor of transcription as the key regulator of SARS-CoV-2 infection.
The study also involved researchers from New York University-USA and Albert Einstein College of Medicine, Bronx, New York, USA
Using organoid models, the study team systematical...
SARS-CoV-2 Research - ORF6 And NSP13 Proteins Cause Degradation Of The DNA Damage Response Kinase Mar 15, 2023 2 years ago
SARS-CoV-2 Research: A new study by Italian researchers have found that the SARS-Cov-2 ORF6 and NSP13 proteins cause degradation of the DNA Damage Response or DDR involving the kinase CHK1 through proteasome and Autophagy.
The study team comprised of researchers from:
-IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy
-International Centre for Genetic Engineering an...
SARS-CoV-2 Research - Spike And ORF-9B Proteins Impairs Contractile Function In Cardiomyocytes! Mar 14, 2023 2 years ago
SARS-CoV-2 Research: Scientists from Clemson University, South Carolina-USA, Stanford University School of Medicine, California-USA, Southern Illinois University School of Medicine-USA, Shandong University, Jinan-China and University of Pittsburgh-USA have in a new study found that ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in ...
Long COVID News - Prosopagnosia - Face Blindness Mar 14, 2023 2 years ago
Long COVID-19 News: A new study by researchers from Dartmouth College, Hanover, New Hampshire USA has found that SARS-Cov-2 infections can lead to individuals developing visual impairments including prosopagnosia!
Prosopagnosia (also known as face blindness or facial agnosia) is a neurological disorder characterized by the inability to recognize faces. There is no treatment for the condit...
COVID-19 News - India - XBB.1.16 Mar 14, 2023 2 years ago
COVID-19 News: India has reported in the last 3 weeks a rise in various respiratory infections along with an increase in hospitalizations and also ICU admissions.
While physicians and hospitals across India are also reporting an increase in mortality rates…state and federal health and government authorities have not come up with any public statements nor have has there been any proper co...
COVID-19 News - Vasculitis - Children Mar 13, 2023 2 years ago
COVID-19 News: Limited information is available on cases of skin and central nervous system vasculopathy associated with COVID-19 in children, despite several such cases being reported.
Russian scientist and pediatricians conducted a retrospective-prospective case series study that included information on four children with COVID-19-associated vasculitis.
In each case, they provide...
Pharma News -Silver Nanoparticles - Antivirals - COVID-19 - H5N1 Mar 13, 2023 2 years ago
Pharma News: The ongoing COVID-19 pandemic with the emergence of new variants and sub-lineages have made identifying effective treatments become even more challenging.
Unknown to many, drug resistance has developed in many of these new sub-lineages not only with the used of officially approved antivirals such as remdesivir, paxlovid, molnupiravir, favipiravir but even with drugs unofficially an...
COVID-19 Supplements - Omega 3 Fatty Acids Mar 13, 2023 2 years ago
COVID-19 Supplements: A new study by researchers from the Fatty Acid Research Institute, Sioux Falls-USA, Sanford School of Medicine, University of South Dakota, Sioux Falls-USA and College of Nursing, University of Illinois–Chicago-USA
delved into the potential protective effects of omega-3 fatty acids, specifically EPA and DHA, in relation to contracting and/or experiencing negative outcom...