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The U.S. Food and Drug Administration today approved Ultomiris (ravulizumab) injection for the treatment of adult patients with paroxysmal nocturnal hemoglobinuria (PNH), a rare and life-threatening blood disease.
“The approval of Ultomiris will change the way that patients with PNH are treated,” said Richard Pazdur, M.D., director of the FDA’s Oncology Center of Excellence and...
Source: Massachusetts General Hospital Jan 13, 2019 6 years ago
A study from a Massachusetts General Hospital (MGH) research team has identified the specific function of a protein found in HIV and related viruses that appears to slow down viral spread in the earliest stages of infection. But they also found that, after initially slowing down the spread of infection, that function may help the virus survive later on by evading the immune response. Their report ...
Source: VIB (the Flanders Institute for Biotechnology) Jan 13, 2019 6 years ago
Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2% of the Western population. Cytokine blockade of Tumor necrosis factor (TNF) and more recently Interleukin-17 (IL-17) has revolutionized the perspectives of patients suffering from this disease by achieving high levels of therapeutic efficacy. The disease differs substantially from rheumatoid arthr...
Source: University of Texas MD Anderson Cancer Center Jan 12, 2019 6 years ago
Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers.
The University of Texas MD Anderson Cancer Center research team found overexpression of the immune checkpoint VISTA on immune cells, especially macrophages, that infiltr...
Source: VIB (the Flanders Institute for Biotechnology) Jan 12, 2019 6 years ago
Alzheimer's-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-β. However, this amyloid-β is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades. A team of scientists at VIB and KU Leuven led by professors Joris de Wit and Bart De Strooper has now uncovered that this amyloid pre...
Source: Loyola University Health System Jan 12, 2019 6 years ago
A landmark study co-authored by a Loyola Medicine oncologist has found that a newer targeted drug is significantly more effective than standard therapy for treating elderly patients with chronic lymphocytic leukemia (CLL).
The drug, ibrutinib, attacks cancer cells without damaging normal cells, thus causing fewer side effects. The drug is taken as a pill once a day -- much more convenient than ...
Source: University Of Basel Jan 11, 2019 6 years ago
The most deadly aspect of breast cancer is metastasis. It spreads cancer cells throughout the body. Researchers at the University and the University Hospital of Basel have now discovered a substance that suppresses the formation of metastases. In the journal Cell, the team of molecular biologists, computational biologists, and clinicians reports on their interdisciplinary approach.
The ima...
Source: University of Louisville Jan 10, 2019 6 years ago
Scientists at the University of Louisville have shown that a microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, can reduce and protect against inflammatory bowel disease (IBD). Millions of people worldwide suffer from IBD in the form of either ulcerative colitis or Crohn's disease, and few effective long-term treatments are available.
Illustration s...
Source: National Multiple Sclerosis Society Jan 10, 2019 6 years ago
An immune system drug may help prevent or slow complications in a type of multiple sclerosis known as secondary progressive MS, a new study finds.
The medication is called rituximab (Rituxan). It's used to treat a number of conditions, including certain blood cell cancers and the autoimmune condition rheumatoid arthritis.
The new Swiss study found that MS patients taking the drug reported ...
Source: Johns Hopkins University School of Medicine Jan 10, 2019 6 years ago
New research from Johns Hopkins Medicine and Sheppard Pratt Health System shows that people in the study with schizophrenia also have higher levels of antibodies against the Epstein-Barr virus (EBV), a herpes virus that causes infectious mononucleosis, so-called mono.
Researchers proposed two explanations for the association of heightened immune responses in patients with schizophrenia and EBV in...
Source: Arizona State University Jan 09, 2019 6 years ago
In a new study, researchers at the Biodesign Institute explore a safe and simple treatment for one of the most devastating and perplexing afflictions: Alzheimer's disease (AD).
Lead authors Ramon Velazquez and Salvatore Oddo, along with their colleagues in the ASU-Banner Neurodegenerative Disease Research Center (NDRC), investigate the effects of choline, an important nutrient that ma...
Source: Rutgers Robert Wood Johnson Medical School. Jan 08, 2019 6 years ago
Women with chronic pain or discomfort around the vulva showed improved sexual function with an oral nerve pain medication used to treat pain caused by a previous herpes infection as well as fibromyalgia, according to a Rutgers study.
The study, which was the first to analyze sexual function in women with vulva pain treated with Gabapentin, appeared in the American Journal of Obstetri...
Source: University Health Network Jan 08, 2019 6 years ago
A clinical-scientific team specializing in head-and-neck cancer has identified a way to manipulate metabolism to potentially curb skin fibrosis -- a common side effect of radiotherapy affecting quality of life of cancer survivors.
The study findings from the laboratory of principal investigator Dr. Fei-Fei Liu, Chief, Radiation Oncology, Princess Margaret Cancer Centre, University Health Networ...
Source: Johns Hopkins University School of Medicine Jan 08, 2019 6 years ago
Johns Hopkins researchers have identified a protein involved in cell proliferation and the development of new blood vessels that could serve as a marker for the early detection of colorectal cancers.
In laboratory studies, investigators found that expression of the protein, called beta-1,4-galactosyltransferase-V (beta-1,4-GalT-V), was increased in human colorectal cancer tumor cells compared ...
Staff Writer, Thailand Medical News Jan 07, 2019 6 years ago
Despite having some of the best vantage points in term of being a being an excellent tourism destination coupled with some of the best medical facilities and hospitals in the world, Thailand is gradually losing its edge as a Medical Tourism destination in the region due to a variety of factors.
Among the top three factors amidst an assortment of reasons are: a) Lack of Proper Medical Mark...
Source: DGIST (Daegu Gyeongbuk Institute of Science and Technology) Jan 07, 2019 6 years ago
A research team led by Professor Sung Bae Lee of Brain and Cognitive Sciences and Professor Daehee Hwang of New Biology (Vice-head of the Plant Age and Life Research Group, IBS) has identified the early neuropathology mechanism of structural characteristics of polyglutamine toxic protein on neurodegenerative brain disorders. It was through a joint research with Professor Yuh Nung Jan at the Howard...
Source: Baylor College of Medicine Jan 06, 2019 6 years ago
Fungal infections are emerging as a major medical challenge, and a team led by researchers at Baylor College of Medicine has developed a mouse model to study the short-term consequences of fungal infection in the brain.
The researchers report in the journal Nature Communications the unexpected finding that the common yeast Candida albicans, a type of fungus, can cross the blood-b...
Source: Massachusetts Institute of Technology Jan 06, 2019 6 years ago
Messenger RNA, which can induce cells to produce therapeutic proteins, holds great promise for treating a variety of diseases. The biggest obstacle to this approach so far has been finding safe and efficient ways to deliver mRNA molecules to the target cells.
In an advance that could lead to new treatments for lung disease, MIT researchers have now designed an inhalable form of mRNA. This aerosol...
Source: University Of Bergen Jan 05, 2019 6 years ago
Diabetes is caused by damaged or non-existing insulin cells inability to produce insulin, a hormone that is necessary in regulating blood sugar levels. Many diabetes patients take insulin supplements to regulate these levels.
In collaboration with other international researchers, researchers at the University of Bergen have, discovered that glucagon.producing cells in the pancreas, can change i...
Source: Princeton University Jan 04, 2019 6 years ago
By simultaneously tackling two mechanisms for cancer's growth, an experimental therapy reduced the spread of triple-negative breast cancer in a study conducted in mice.
The therapeutic agent, called Tinagl1, is based on a naturally occurring protein and blocks two of the main pathways by which breast cancer cells can grow and migrate out of the primary tumor to spread to other organs in the b...
The health care industry is subject to a wide range of laws and regulations, including those related to healthcare reimbursement, social security, hospital, pharmaceuticals, medical devices, and laws regulating the practices of medical professionals.
The National Health Act B.E. 2550 (2007) is considered the principal healthcare law in Thailand. The Act codifies important rights a...
Medical Spheres Announces the set up of a new subsidiary business unit: Med5G Inc with its registered offices at 244 Madison Avenue, 10016-2817 New York City, NY, USA and its Thailand branch: Med5G Co Ltd with offices at 907/854, Moo 9, Chaengwattana Road, Pakred, Nonthaburi 11120, Thailand.
Med5g is a full spectrum Medical and Healthcare orientated IT and Software Development entity ...
Source: Oregon State University Jan 03, 2019 6 years ago
A research study at Oregon State University has shown that a higher intake of vitamin C is crucial for metabolic syndrome patients trying to halt a potentially deadly cycle of antioxidant disruption and health-related problems. Metabolic syndrome affects more than 30 percent of the global adult population and this findings might provide some relief to a majority of them.
"What these finding...
Unfortunately, we do not recommend touching any Thai stocks or even Asian stocks at the moment considering the strong volatility plus pessimistic outlook for Thailand and the region. Furthermore, considering many political uncertainities in Thailand, its best to stay clear on investing in the Thailand SET for the time being.. The US however, still possess many lucrative and interesting deals.
&n...
Source: University Of California -Berkeley Jan 02, 2019 6 years ago
A new neurostimulator developed by engineers at the University of California, Berkeley, can listen to and stimulate electric current in the brain at the same time, potentially delivering fine-tuned treatments to patients with diseases like epilepsy and Parkinson's.
In a proposed device, two of the new chips would be embedded in a chassis located outside the head. Each chip could monitor ele...
Diabetes, also known as diabetes mellitus, is a common metabolic disease that is characterized by frequent sessions of uncontrolled high blood sugar or hyperglycaemia caused by poor insulin production or increased resistance to insulin. The World Health Organization (WHO) has reported that 8.5% of the global population was affected by diabetes in 2014, or roughly 422 million people.1
Diabetes is ...
Source: Joseph O' Connor and Son Nguyen (Thai Examiner.Com) Jan 01, 2019 6 years ago
New move could be bad news for many middle aged foreigners and particularly elderly individuals who have been unable to get health insurance coverage before. Anecdotal evidence suggests that many are in this category with a range of health conditions including diabetes, heart complaints and even cancer. While the proposal has yet to be fully clarified and presented to the Thai cabinet, the concern...
A hospital in Thailand facing a shortage of nurses has turned to robots to fill the void. With a recent heavy influx of new patients, The Mongkutwattana General Hospital in Bangkok can’t find enough qualified human staff to keep up with demand. They have recently hired three robot nurses and even dressed them in the hospital’s yellow uniform.
The robot nur...
Changing your lifestyle could be a big step toward diabetes prevention — and it's never too late to start. Consider these tips.
When it comes to type 2 diabetes — the most common type of diabetes — prevention is a big deal. It's especially important to make diabetes prevention a priority if you're at increased risk of diabetes, such as if you're overweigh...
AstraZeneca announced a new collaboration with Cancer Research UK to launch a centre of excellence in genetic screening, cancer modelling and big data processing aimed at accelerating the discovery of new cancer medicines.
The Functional Genomics Centre will further develop CRISPR technology to better understand the biology of cancer, creating biological models that may be more reflect...
Adinun Kittiratanapaibool,M.D., Director of Samitivej Srinakarin Hospital recently launch an event “Don’t Mind Age, Live Life to the Fullest” at its hospital premises .The event was aimed at showing propective patients that the hospital has repositioned itself to cater for the greying elderly market both in terms of its services and also facilities. The vent kic...
Source: Teva Pharmaceuticals Jan 01, 2019 6 years ago
The FDA has approved the first inhaler with built-in monitoring sensors to track medication adherence for asthma and COPD patients, according to Teva Pharmaceutical Industries Ltd. The ProAir Digihaler (albuterol sulfate 117 mcg) inhalation powder is equipped with built-in sensors that connect via Bluetooth to a companion mobile application, which stores data.
Teva's &nbs...
Source: Vanderbilt University Medical Center Jan 01, 2019 6 years ago
A randomized trial by Vanderbilt-Ingram Cancer Center researchers indicates that magnesium optimizes vitamin D status, raising it in people with deficient levels and lowering it in people with high levels.
According to a recent study, published in the American Journal of Clinical Nutrition, magnesium may help in maintaining optimum vitamin D levels in the body. The randomised study that had 250...
Source: University Of South Australia Jan 01, 2019 6 years ago
One of the biggest health issues could be checked if more people took up yoga or tai chi and reduced their blood pressure, an Australian study has found.
Stroke costs the world $120 billion a year through treatment and loss of productivity, affecting 2.6 million people in 2017.
A paper published in Future Neurology by researchers from Monash University, the University of South ...
Source: University of Groningen Jan 01, 2019 6 years ago
A team of researchers with members from the Netherlands and the U.S. has found differences in the numbers of gut microbes for patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). In their paper published in the journal Science Translational Medicine the group describes how they sequenced the genome of gut microbes in patients with bowel problems and what they found.
...
Source: Texas A&M University Jan 01, 2019 6 years ago
A recent study led by researchers in Texas A&M University's department of nutrition and food science shows how a novel regulatory mechanism serves as an important biomarker for the development of diabetes, as well as a potential therapeutic target for its prevention.
The study can be found online in the November edition of the diabetes journal of the American Diabetes Associati...
Source: Johns Hopkins University Jan 01, 2019 6 years ago
A new test for chlamydia can provide results within 30 minutes, potentially speeding up the start of treatment, researchers say.
The rapid test for the sexually transmitted disease means patients can receive treatment immediately, instead of having to wait for a follow-up appointment. This could help reduce the spread of the disease, according to researchers at Johns Hopkins Universit...
Source: Louisiana State University Health Sciences Center Jan 01, 2019 6 years ago
An investigational oral antibiotic called zoliflodacin was well-tolerated and successfully cured most cases of uncomplicated gonorrhea when tested in a Phase 2 multicenter clinical trial, according to findings published in the New England Journal of Medicine. The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health, sponsored the ...
Source: Pasteur Institute Jan 01, 2019 6 years ago
Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus – it is their metabolic (or energy-producing) activity1 that enables the virus to multiply. Thanks to met...
Source: University of Michigan Jan 01, 2019 6 years ago
A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds. It suggests a possible target for prevention strategies, which preliminary work suggests could involve flavonoids derived from cranberries.
"We've known for a long time that esophageal adenocarcinoma primarily affects Caucasians and ver...
Source: Staff Writer, Thailand Medical News Jan 01, 2019 6 years ago
Firibastat By Quantum Genomics is an oral antihypertensive drug that has proved to be safe and effective and well-tolerated in the NEW-HOPE, a phase 2b clinical trial focused on an understudied and underserved patient population composed largely of overweight or obese, high-risk, hypertensive racial minorities.
Firibastat is the first brain aminopeptidase A inhibitor. It selec...
Source: Medical University of Vienna Jan 01, 2019 6 years ago
A type of glycoproteins ie carbohydrate binding proteins, called galectins, plays an important role in the degeneration of cartilage in osteoarthritis. A research group at the Medical University of Vienna was able to demonstrate this correlation, in cooperation with international study partners. In osteoarthritis, certain galectins are produced by the cartilage cells themselves and accelerate the ...
Source: Thailand Medical News Jan 01, 2019 6 years ago
A company is in Houston, Texas is introducing new acoustic shockwave technology for quicker laser tattoo removal. What’s more, the new device also shows potential in aesthetics market for cellulite and fat removal.
The patented Rapid Acoustic Pulse (RAP) device by Soliton Inc, uses acoustic shockwaves that accelerated the speed of tattoo removal when used with lasers, delivering results i...
Source: University of California San Diego Jan 01, 2019 6 years ago
Dermal fibroblasts are specialized cells deep in the skin that generate connective tissue and help the skin recover from injury. Some fibroblasts have the ability to convert into fat cells that reside under the dermis, giving the skin a plump, youthful look and producing a peptide that plays a critical role in fighting infections.
Studies by the University of California San Diego School of Medic...
Source: Albert Einstein College of Medicine, Bronx, NY, USA. Jan 01, 2019 6 years ago
Scientists have created a cheaper, faster, reproducible diagnostic technique that has the potential to predict the risk of metastasis in prostate cancer.
For patients who are newly diagnosed, or patients previously treated, the risk of metastasis in prostrate cancer is a crucial factor of whether to choose conservative management or undergo further treatment. For prostate as we...
Source: University Of Zurich Jan 01, 2019 6 years ago
Cystic fibrosis is a severe hereditary disease of the lung, for which there is currently no cure. The underlying cause of the disease is a malfunction of the chloride channel CFTR, which prevents the secretion of chloride in certain body cells. This leads to dehydration of the mucus layer in the lung. A promising approach for treating cystic fibrosis is the activation of the calcium-activated chlo...
Cleveland Clinic researchers have shown, for the first time in humans, that choline is directly linked to increased production of a gut bacteria byproduct that increases the risk of blood-clotting events like heart attack and stroke. However, the research also showed that adding a low dose of aspirin may reduce that risk.
In a small interventional study, the researchers provided oral choline, s...
A team of researchers led by Osaka University examined the dissemination of colistin-resistant bacteria among residents of rural communities in Vietnam to find that the prevalence of colistin-resistant Escherichia coli (CR-E) in the intestines was extremely high, at about 70 percent. This Escherichia coli (E. coli) is a non-pathogenic bacterium, so the residents have no symptom...
Source: Max Delbrück Center for Molecular Medicine Dec 29, 2018 6 years ago
The fatty acid propionate helps defend against the effects of high blood pressure, including atherosclerosis and heart tissue remodeling, a study on mice has found. Gut bacteria produce the substance—which calms the immune cells that drive up blood pressure—from natural dietary fiber.
"You are what you eat," as the proverb goes. But to a large extent our well-being also dep...
Source: University of Southern California Dec 28, 2018 6 years ago
A new study by Keck School of Medicine of USC researchers shows there's yet another reason to avoid a high fat, high cholesterol diet: It can trigger changes in the immune system that lead to a serious form of non-alcoholic fatty liver disease (NAFLD) known as non-alcoholic steatohepatitis (NASH).
NAFLD is one of the most common causes of liver disease in the United States, and an estimated 2...
Columbia University Irving Medical Center Dec 27, 2018 6 years ago
A new study has found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and that identifying the responsible genes has a direct impact on treatment for most of these patients.
“Our study shows that genetic testing can be used to personalize the diagnosis and management of kidney disease, and that nephrologists should consider incorporating it into the diagnost...
Source: University Of Toronto Dec 26, 2018 6 years ago
Letrozole was found to damage normal function in the hippocampus of monkeys
The animals also showed anxiety and hot flashes after four weeks of treatment
Side effects like fatigue are experienced by up to 30% of women on the drug
A drug commonly given out to breast-cancer patients may affect their brain function and memory, research suggests.Letrozole is primarily used to treat b...
Source: Dallas Morning News (Anna Kuchment) Dec 25, 2018 6 years ago
Medical researchers fear that more children will develop paralysis from a mysterious polio like illness that has struck every two years since 2014. The condition, known as acute flaccid myelitis, or AFM, is rare and has reached its peak for 2018. It will likely continue to fade as winter approaches. But many believe it will be back.
D68 Enterovirus
"AFM is here, and it doesn't se...
Source: University of Bristol Dec 24, 2018 6 years ago
Scientists have identified a growth factor found in the kidneys that could minimise the diabetes-inducing effects of blood vessel damage. The research, led by experts in renal disease and translational health sciences from the University of Bristol focused on a group of growth factors categorised as VEGFs, or vascular endothelial growth factors. These are growth factors produced by...