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Source: Alphatec Inc, California Mar 03, 2019 6 years ago
Alphatec Inc based in California, recently obtained US FDA clearance for the SafeOp automated neuromonitoring system for use in real-time intraoperative nerve location and assessment. The system relies on somatosensory evoked potential (SSEP) and and electromyography (EMG) as the two complementary modalities, one for evaluating the functionality of nerves and the other their locati...
AstraZeneca and MSD have announced positive results from the Phase III POLO trial, in which there was a statistically significant and clinically meaningful improvement in progression-free survival (PFS) with Lynparza (olaparib) for pancreatic cancer, making it the first PARP inhibitor to demonstrate benefit in the disease.
The drug is a first-in-class PARP inhibitor, and the first targeted treat...
The World Cancer Research Fund reports that 30 to 50 percent of cancer cases are preventable, and it is important to focus on stopping cancer from developing in the first place. Many natural foods contain a variety of antioxidants and phytochemicals that possess the capability of preventing cancer from developing coupled with a proper lifestyle.
Xiang-Dong Wang, a senior scientist and associate...
Source: University of Alabama at Birmingham Mar 02, 2019 6 years ago
In a paper recently published in the Journal of Infectious Diseases, researchers examined the effect of vaginal tenofovir 1 percent gel use on the risk of acquiring herpes simplex virus type 2, or HSV-2. The study was conducted through a secondary analysis of data from the VOICE study.
According to the Centers for Disease Control and Prevention, more than one in six Americans ages 14 to 49 ...
Source: University of Pittsburgh Mar 01, 2019 6 years ago
A single misbehaving protein -- called TDP-43 -- is behind 97 percent of amyotrophic lateral sclerosis (ALS) cases and 45 percent of frontotemporal dementia diagnoses. It also is found in 80 percent of chronic traumatic encephalopathy and 60 percent of Alzheimer's disease cases. Now, University of Pittsburgh researchers have found a way to trap TDP-43 so it doesn't form toxic clumps that c...
Source: University of Michigan Feb 28, 2019 6 years ago
A protein molecule called EZH2, known to play a role in cancer may also be increasing fibrosis in scleroderma patients.
Studies and researches that have been made show that Scleroderma, a rare chronic autoimmune disease, causes difficulties during breathing, exhaustion and most concerningly hardens the internal organs and the skin.
“Tissues and organs are damaged due to...
Source: Children's Hospital of Philadelphia Feb 27, 2019 6 years ago
New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders -- complex conditions with severe energy deficiency for which no proven effective treatments exist. Future clinical research is needed to explore whether the drug, cysteamine bitartrate, will meaningfully benefit patient...
Source: Indiana University, US Feb 26, 2019 6 years ago
A breakthrough test developed by Indiana University School of Medicine researchers to measure pain in patients could help stem the tide of the opioid crisis in Indiana, and throughout the rest of the nation.
A study led by psychiatry professor Alexander Niculescu, MD, PhD and published this week in the Nature journal Molecular Psychiatrytracked hundreds of participants at the Richard L. Ro...
Source: University of Virginia Health System Feb 25, 2019 6 years ago
Researchers at the University of Virginia School of Medicine have identified an unexpected contributor to rheumatoid arthritis that may help explain the painful flare-ups associated with the disease. The discovery points to a potential new treatment for the autoimmune disorder and may also allow the use of a simple blood test to detect people at elevated risk for developing the condition.
The pr...
Source: Vanderbilt University Feb 24, 2019 6 years ago
A well-known, four-year study found popular arthritis drug Celebrex no more dangerous for the heart than older drugs in its same classification - commonly called NSAIDs. Now, a big-data analysis of patient records at Vanderbilt University has found a link specifically between Celebrex and heart valve calcification.
W. David Merryman, professor of biomedical engineering, and Ph.D. student Megan B...
Source: Rutgers University Feb 24, 2019 6 years ago
A Rutgers study has found that a specific gene in cancerous prostate tumors indicates when patients are at high-risk for the cancer to spread, suggesting that targeting this gene can help patients live longer.
The study, which was published in the journal Nature Communications, identified the NSD2 gene through a computer algorithm developed to determine which cancergenes that spread in a&nb...
Source: Vanderbilt University Feb 23, 2019 6 years ago
Verticilide, an extract from the genus of fungus Verticillium, commonly found on plants and insects, is a promising compound to treat arrhythmia according to a research from a collaboration between Vanderbilt University professors of chemistry and medicine.
Jeffrey Johnston, Stevenson Professor of Chemistry, said the natural product isn't active except in insects, but the synthetic mirror-i...
We continue our series of stock recommendations, still focusing on Medical and Biotech stocks in the US, as considering the political uncertainties facing Thailand, its best to stay clear of the Thailand Stock Market for the rest of the year. Medical and Biotechnology stocks are simultaneously one of the most exciting and one of the riskiest corners of the stock market. Biotech co...
Source: University of California - Riverside Feb 22, 2019 6 years ago
Multiple sclerosis is an autoimmune disease that affects more than 2.3 million people worldwide. This debilitating condition periodically shutters communication between the brain and other parts of the body, resulting in symptoms that range from numbness and tingling in the arms and legs to blindness and paralysis. While treatments are available to alleviate inflammation, no therapies exist to pro...
Source: Thailand Medical News Feb 21, 2019 6 years ago
Doctors In Thailand practicing primary care medicine in 2019 have likely met this familiar greeting from a patient: “I Googled my symptoms and I think the problem is [insert condition].” Obviously, this can be unsettling for many providers – doctors in the past were often the first point of reference for patients who otherwise had no way of researching their health concerns on th...
Source: San Diego School Of Medicine Feb 20, 2019 6 years ago
Proton pump inhibitors (PPIs), which include well-known brand names Prilosec, Miracid, Nexium and Prevacid, are among the most commonly prescribed medications in the world. Approximately 10 percent of adults in the United States take these drugs for frequent heartburn, acid reflux and gastroesophageal reflux disease. Given their prevalence, researchers at Skaggs School of Pharmacy and Pharmaceutic...
Source: University Of Melbourne Feb 19, 2019 6 years ago
Scientists from the University Of Melbourne said on Monday that they had discovered immune cells that can fight all known flu viruses in what was hailed as an "extraordinary breakthrough" that could lead to a universal, one-shot vaccine against the killer disease.
Influenza epidemics, largely seasonal, kill hundreds of thousands of people each year, according to the World Health ...
Osteoarthritis is the most common of the more than 200 forms of arthritis, affecting over 20 per cent of the population. Unfortunately, there are currently no effective treatments or approved drugs for this disabling condition, which causes the joints to become painful and stiff. Some new drugs are in the pipeline, but it will be years before they are tested in clinical trials and ...
Source: Dana-Farber Cancer Institute Feb 18, 2019 6 years ago
A combination of two drugs -- one of them an immunotherapy agent -- could become a new standard, first-line treatment for patients with metastatic kidney cancer, says an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.
Patients who received the immunotherapy drug avelumab plus axitinib, a targeted agent, had a significant advantage in progression-...
Overcoming Formulation Challenges of Biotherapeutics:
The increasing study of vaccines and biotherapeutics gives promise for improvement of treatments against various diseases. While protein engineering has shown a great level of growth, several of these therapies persist in the face of ex vivo uncertainty challenges (both physical and chemical instability) which are a source of dosage form inadeq...
Source: Thailand Medical News Feb 17, 2019 6 years ago
Multiple therapies involving ablative and nonablative techniques have been developed for rejuvenation of photodamaged skin. Monopolar radiofrequency (RF) is emerging as a gentler, nonablative skin-tightening device that delivers uniform heat to the dermis at a controlled depth.
In a recent study done by Dr Moetaz El-Domyati, Head of Dermatologists at Minia University, Egypt in collaborati...
Source: Thailand Medical News Feb 17, 2019 6 years ago
Updated treatment guidelines and the availability of the ResistancePlus GC test for Neisseria gonorrhoeae, from SpeeDx Inc, Sydney, Australia, are making it possible for some UK patients with gonorrhea to be treated with the cheap and easily-administered oral antibiotic ciprofloxacin.
Ciprofloxacin was the first-line antibiotic of choice for uncomplicated gonorrhea in the ...
Source: St Thomas' Biomedical Research Centre Feb 17, 2019 6 years ago
A new technique using patients' own modified cells to treat Crohn's disease has been proven to be effective in experiments using human cells, with a clinical trial of the treatment expected to start in the next six months.
Researchers at the NIHR Guy's and St Thomas' Biomedical Research Centre (BRC) developed the technique by studying white blood cells taken from patien...
Source: NRG Oncology, Pennsylvania Feb 17, 2019 6 years ago
The NRG Oncology clinical study NRG-RTOG 0415 determined that a hypofractionated radiotherapy schedule (H-RT), a treatment schedule that delivers a total dose of radiotherapy over a shorter period of time, is not worse than the conventional radiotherapy schedule (C-RT) in terms of bowel, bladder, sexual, and general quality of life (QOL) as well as anxiety and depression for men with low risk pros...
Twelve patients who tried injections of stem cells were hospitalized with infections, according to a report in the New York Times that should cause patients concern. More important is that they should investigate stem cell treatments, for conditions such as cartilage injuries to their joints, before committing to one of these procedures. It's also a valuable reminder that physic...
Source: Oregon Health and Science University Feb 16, 2019 6 years ago
A team of researchers from Oregon Health and Science University has concluded from an extensive study involving a medicinal plant called Centella Asiatica, commonly known as Gotu Kola (in thai: bua bok ) is effective in terms of improving memory especially in the elderly and those afflicted with cognitive related diseases.
Centella Asiatica contains a variety of phyto chemicals such ...
Source: University of Exeter Feb 16, 2019 6 years ago
Scientists have discovered new ways in which the body regulates blood clots, in a discovery which could one day lead to the development of better treatments that could help prevent and treat conditions including heart diseases, stroke and vascular dementia.
Led by the University of Exeter and funded by the British Heart Foundation, the team has developed a new technique that allows ...
Takeda Pharmaceutical Company Feb 15, 2019 6 years ago
– ADCETRIS in Combination with AVD (Adriamycin, Vinblastine and Dacarbazine) Demonstrated 29-Percent Reduction in the Risk of Progression, Death or Need for Additional Anticancer Therapy for CD30+ Stage IV Patients
– Milestone Marks Fifth Approved Indication for ADCETRIS in Europe, Reinforcing Takeda’s Commitment to Developing Innovative Solutions for People Li...
Source: George Mason University Feb 15, 2019 6 years ago
George Mason University's Yuntao Wu is the lead scientist on a research team that has identified a measurable indicator that could prove instrumental in the fight against HIV.
The research focuses on cofilin, a key protein that regulates cells to mobilize and fight against infection.
In an HIV-infected patient, cofilin dysfunction is a key factor in helper T cell defects, according to the r...
Source: ETH Zurich University Feb 15, 2019 6 years ago
In recent years, the number of targeted cancer drugs has continued to rise. However, conventional chemotherapeutic agents still play an important role in cancer treatment. These include platinum-based cytotoxic agents that attack and kill cancer cells. But these agents also damage healthy tissue and cause severe side effects. Researchers at ETH Zurich have now identified an approach that allows fo...
Source: University Hospital Basel Feb 15, 2019 6 years ago
There is a higher risk of fragility bone fracture for people with diabetes, and a new study was able to identify a key factor specific to type 1 diabetes (T1D) patients.
The study in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism reports that poor glucose control significantly reduces the risk, in T1D patients, of a fall from standing height or...
Source: University of Virginia Feb 15, 2019 6 years ago
An antidepressant drug used to treat obsessive-compulsive disorder could save people from deadly sepsis, new research from the University of Virginia School of Medicine suggests.
Sepsis is a significant cause of death around the world. The federal Centers for Disease Control and Infection calls it "the body's extreme response to an infection." Essentially, the body's immune re...
A variety of health care trackers, including the Apple Watch, offer consumers the ability to record their ECG signals. Though the claims about these offerings are mostly accurate, they may be misleading to those that believe these devices mimic the capabilities of in-hospital ECGs. In reality, wrist-worn and other wearable ECG monitors are only single-lead devices that can pretty much only detect ...
As in much of the rest of the developed and middle-income nations, diabetes is creating a public health crisis in Thailand. Doctors face a complicated set of challenges related to the illness – not only in how to treat those already affected, but how to prevent the debilitating disease moving into the future. Measures such as proper dietary education and the promotion of exercise, especially...
Source: University of Leicester Feb 14, 2019 6 years ago
Results from a phase II clinical trial, experimental work on cells and computational modelling have together shown why the first pill for asthma in 20 years can help reduce asthma attacks.
Researchers from Leicester (UK) and Vancouver (Canada) have shown that the investigational drug, Fevipiprant (an oral, selective prostaglandin D2 receptor antagonist), reduces the amount of smooth muscle in t...
Source: University of Cambridge/ University of Leicester Feb 13, 2019 6 years ago
A blood test has been developed that could save countless lives by improving early detection of lung cancer. The test measures circulating DNA that is shed by cancer cells as they grow and multiply. Scientists believe it could predict the presence of low-grade tumours in the lungs long before they become a threat.
New research led by scientists at the Medical Research Council (MRC) Toxico...
Source: Stanford University School of Medicine Feb 12, 2019 6 years ago
An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at the Stanford University School of Medicine.
The researchers believe the treatment could circumvent the need to use harsh, potentially life-threatening chemotherapy or radiati...
Source: Beth Israel Deaconess Medical Center Feb 11, 2019 6 years ago
Lightheadedness with standing, otherwise known as postural lightheadedness, results from a gravitational drop in blood pressure and is common among adults. While mild in many adults, it has been cited as an important contributing factor in some harmful clinical events, such as falls. As a result, greater sodium intake is widely viewed as an intervention for preventing lightheadedness when moving f...
Source: The Institute of Cancer Research, London Feb 10, 2019 6 years ago
A brand new type of cancer drug that acts as a ‘Trojan horse’ to get inside tumour cells has shown promise in patients with six different cancer types.
In patients with advanced, drug-resistant cancers, over a quarter with cervical and bladder tumours, and nearly 15 per cent with ovarian and lung tumours, responded to the new treatment.
The innovative new drug, called tisotumab ved...
Source: Duke University Medical Center Feb 09, 2019 6 years ago
The use of MRI to determine heart function has been slow to catch on, but a study from Duke Health researchers shows that stress cardiac MRI not only diagnoses disease, but can also predict which cases are potentially fatal.
Results from a large, multi-center study suggest that cardiac magnetic resonance, or CMR, has potential as a non-invasive, non-toxic alternative to stress echocardiograms, ...
Source: Massachusetts Institute of Technology Feb 08, 2019 6 years ago
An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin, potentially replacing the injections that people with type 2 diabetes have to give themselves every day.
An MIT-led research team has developed a drug capsule that could
be used to deliver oral doses of insulin. Credit: Felice Frankel
About the size of a blueberry, the capsule contains a...
Source: Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Brazil Feb 07, 2019 6 years ago
Scientists explored mRNA and protein public databases to unravel hidden meanings of the genetic code. Using a metric derived from mRNA codon composition, they found out how gene sequence choice can predict different aspects of protein synthesis, such as protein production efficiency. The study could help the development of new biotechnological applications of genes and proteins.
Today, thousand...
Thailand’s PrEP Implementation Progress With Exclusive Interview Comments From Professor Andrew Grulich – The Kirby Institute, UNSW, Sydney
PrEP implementation was a very hot, challenging topic at the 21st Bangkok International Symposium on HIV Medicine 2019 organised by HIV-NAT.
The Symposium was held at The Queen Sirikit National Convention Centre, January 16-18th..
The latter par...
Executives of Chiang Mai Ram Hospital recently paid a visit to the Myanmar Consulate in Chiang Mai to discuss cooperation between Myanmar and the Hospital’s initiative to a be a centre for Myanmar Patients seeking premium healthcare services.
The delegation led by Dr. Pramuk Unachak and Dr. Sira Hantrakul, Directors of the hospital along with its Customer Services Team met up with the Con...
Source: University Of Waterloo Feb 07, 2019 6 years ago
Researchers at the University of Waterloo have developed a new way to prevent and treat Chlamydia, the most common sexually transmitted bacterial infection in the world.
Chlamydia in a human cell.
The new treatment differs from the traditional anti-biotic treatment as it is a type of gene therapy that is delivered via nanotechnology and is showing a 65 per cent success rate in preventing c...
Source: Thailand Medical News Feb 06, 2019 6 years ago
Fat is complicated. It's stubborn, demonized, praised, misunderstood. As the recent wave of body positive conversations has helped to scratch at, everyone's relationship with fat is different. One thing that has remained fairly consistent is a cultural obsession with mastering fat — whether that means embracing it, or erasing it.
As far as the latter is concerned, plastic surgery ha...
Source : American Physiological Society. Feb 06, 2019 6 years ago
Lower-than-normal zinc levels may contribute to high blood pressure (hypertension) by altering the way the kidneys handle sodium. The study is published in the American Journal of Physiology -- Renal Physiology.
Zinc deficiency is common in people with chronic illnesses such as type 2 diabetes and chronic kidney disease. People with low zinc levels are also at a higher risk for hyper...
Source: Stanford University School of Medicine Feb 06, 2019 6 years ago
In rheumatoid arthritis, immune cells called helper T cells behave differently from their counterparts in healthy cells and in other autoimmune diseases. Stanford scientists have learned why.
Stanford University School of Medicine investigators succeeded in countering inflammation and tissue damage caused by rheumatoid arthritis in mice engrafted with human joint-lining tissue and...
Source: Cancer Research UK Feb 06, 2019 6 years ago
Mutations that cause esophageal adenocarcinoma (OAC) have been mapped in unprecedented detail -- unveiling that more than half could be targeted by drugs currently in trials for other cancer types.
This research, published in Nature Genetics, could help stratify esophageal cancer patients to give them more personalised therapies. This could provide options not currently available to ...
Tris Pharma Inc. voluntarily recalled three lots of Infants’ Ibuprofen Concentrated Oral Suspension, USP 50 mg per 1.25 mL, to the retail level. The recalled lots of the product have been found to have potentially higher concentrations of ibuprofen than normal.
Images of packagings of recalled products
“There is a remote possibility that infants, who may be more susceptible to...
Source: Friedrich-Alexander Universitat(FAU),Germany Feb 05, 2019 6 years ago
More than 4000,000 people in Germany are affected by the chronic inflammatory bowel diseases Morbus Crohn or ulcerative colitis. Patients often suffer from flare-ups, which damage intestinal tissue. In spite of tremendous advances in treating the diseases with medication, the chronic inflammation still cannot be kept sufficiently in check for a number of patients. Until now, little has been known ...
Contributed By Benjamin Bartee Feb 05, 2019 6 years ago
Thailand, Bangkok in particular, has emerged in recent decades as the worldwide leader in medical tourism, while simultaneously achieving interrelated healthcare milestones, with enormous tangential benefits to its own economy and population as well as to the world at large. Estimates by the U.S. National Library of Medicine indicate that, in 2013, the Kingdom attracted between 700,000 and 2.5 mil...
Source: McGill University Feb 05, 2019 6 years ago
Two new papers, published simultaneously in Nature Communications and led by researchers at McGill University, offer promise that a drug currently used to treat estrogen positive breast cancer may be effective in treating two different types of cancer, one rare and one common form.
The breakthrough discovery launching this research came in 2014 when Dr. William Foulkes, ...
Source: VIB (the Flanders Institute for Biotechnology) Feb 04, 2019 6 years ago
Identical twin toddlers who presented with severe arthritis helped scientists to identify the first gene mutation that can single-handedly cause a juvenile form of this inflammatory joint disease. By investigating the DNA of individual blood cells of both children and then modelling the genetic defect in a mouse model, the research team led by Adrian Liston (VIB-KU Leuven) was able to unravel the ...
Source: University of Texas Health Science Center at San Antonio Feb 04, 2019 6 years ago
In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published in JAMA Oncology, researchers compared four chemotherapy drugs with development of cardiomyopathy (abnormal heart muscle with impaired function) years after treatment.
"Exposure to anthracycline chemotherapies, such ...