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Source: Louisiana State University Health Sciences Center Jan 01, 2019 6 years ago
An investigational oral antibiotic called zoliflodacin was well-tolerated and successfully cured most cases of uncomplicated gonorrhea when tested in a Phase 2 multicenter clinical trial, according to findings published in the New England Journal of Medicine. The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health, sponsored the ...
Source: Pasteur Institute Jan 01, 2019 6 years ago
Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus – it is their metabolic (or energy-producing) activity1 that enables the virus to multiply. Thanks to met...
Source: University of Michigan Jan 01, 2019 6 years ago
A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds. It suggests a possible target for prevention strategies, which preliminary work suggests could involve flavonoids derived from cranberries.
"We've known for a long time that esophageal adenocarcinoma primarily affects Caucasians and ver...
Source: Staff Writer, Thailand Medical News Jan 01, 2019 6 years ago
Firibastat By Quantum Genomics is an oral antihypertensive drug that has proved to be safe and effective and well-tolerated in the NEW-HOPE, a phase 2b clinical trial focused on an understudied and underserved patient population composed largely of overweight or obese, high-risk, hypertensive racial minorities.
Firibastat is the first brain aminopeptidase A inhibitor. It selec...
Source: Medical University of Vienna Jan 01, 2019 6 years ago
A type of glycoproteins ie carbohydrate binding proteins, called galectins, plays an important role in the degeneration of cartilage in osteoarthritis. A research group at the Medical University of Vienna was able to demonstrate this correlation, in cooperation with international study partners. In osteoarthritis, certain galectins are produced by the cartilage cells themselves and accelerate the ...
Source: Thailand Medical News Jan 01, 2019 6 years ago
A company is in Houston, Texas is introducing new acoustic shockwave technology for quicker laser tattoo removal. What’s more, the new device also shows potential in aesthetics market for cellulite and fat removal.
The patented Rapid Acoustic Pulse (RAP) device by Soliton Inc, uses acoustic shockwaves that accelerated the speed of tattoo removal when used with lasers, delivering results i...
Source: University of California San Diego Jan 01, 2019 6 years ago
Dermal fibroblasts are specialized cells deep in the skin that generate connective tissue and help the skin recover from injury. Some fibroblasts have the ability to convert into fat cells that reside under the dermis, giving the skin a plump, youthful look and producing a peptide that plays a critical role in fighting infections.
Studies by the University of California San Diego School of Medic...
Source: Albert Einstein College of Medicine, Bronx, NY, USA. Jan 01, 2019 6 years ago
Scientists have created a cheaper, faster, reproducible diagnostic technique that has the potential to predict the risk of metastasis in prostate cancer.
For patients who are newly diagnosed, or patients previously treated, the risk of metastasis in prostrate cancer is a crucial factor of whether to choose conservative management or undergo further treatment. For prostate as we...
Source: University Of Zurich Jan 01, 2019 6 years ago
Cystic fibrosis is a severe hereditary disease of the lung, for which there is currently no cure. The underlying cause of the disease is a malfunction of the chloride channel CFTR, which prevents the secretion of chloride in certain body cells. This leads to dehydration of the mucus layer in the lung. A promising approach for treating cystic fibrosis is the activation of the calcium-activated chlo...
Cleveland Clinic researchers have shown, for the first time in humans, that choline is directly linked to increased production of a gut bacteria byproduct that increases the risk of blood-clotting events like heart attack and stroke. However, the research also showed that adding a low dose of aspirin may reduce that risk.
In a small interventional study, the researchers provided oral choline, s...
A team of researchers led by Osaka University examined the dissemination of colistin-resistant bacteria among residents of rural communities in Vietnam to find that the prevalence of colistin-resistant Escherichia coli (CR-E) in the intestines was extremely high, at about 70 percent. This Escherichia coli (E. coli) is a non-pathogenic bacterium, so the residents have no symptom...
Source: Max Delbrück Center for Molecular Medicine Dec 29, 2018 6 years ago
The fatty acid propionate helps defend against the effects of high blood pressure, including atherosclerosis and heart tissue remodeling, a study on mice has found. Gut bacteria produce the substance—which calms the immune cells that drive up blood pressure—from natural dietary fiber.
"You are what you eat," as the proverb goes. But to a large extent our well-being also dep...
Source: University of Southern California Dec 28, 2018 6 years ago
A new study by Keck School of Medicine of USC researchers shows there's yet another reason to avoid a high fat, high cholesterol diet: It can trigger changes in the immune system that lead to a serious form of non-alcoholic fatty liver disease (NAFLD) known as non-alcoholic steatohepatitis (NASH).
NAFLD is one of the most common causes of liver disease in the United States, and an estimated 2...
Columbia University Irving Medical Center Dec 27, 2018 6 years ago
A new study has found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and that identifying the responsible genes has a direct impact on treatment for most of these patients.
“Our study shows that genetic testing can be used to personalize the diagnosis and management of kidney disease, and that nephrologists should consider incorporating it into the diagnost...
Source: University Of Toronto Dec 26, 2018 6 years ago
Letrozole was found to damage normal function in the hippocampus of monkeys
The animals also showed anxiety and hot flashes after four weeks of treatment
Side effects like fatigue are experienced by up to 30% of women on the drug
A drug commonly given out to breast-cancer patients may affect their brain function and memory, research suggests.Letrozole is primarily used to treat b...
Source: Dallas Morning News (Anna Kuchment) Dec 25, 2018 6 years ago
Medical researchers fear that more children will develop paralysis from a mysterious polio like illness that has struck every two years since 2014. The condition, known as acute flaccid myelitis, or AFM, is rare and has reached its peak for 2018. It will likely continue to fade as winter approaches. But many believe it will be back.
D68 Enterovirus
"AFM is here, and it doesn't se...
Source: University of Bristol Dec 24, 2018 6 years ago
Scientists have identified a growth factor found in the kidneys that could minimise the diabetes-inducing effects of blood vessel damage. The research, led by experts in renal disease and translational health sciences from the University of Bristol focused on a group of growth factors categorised as VEGFs, or vascular endothelial growth factors. These are growth factors produced by...
Source: University Of Virginia School Of Medicine Dec 23, 2018 6 years ago
A group of genes called SLCs that has been largely ignored by scientists could play critical roles in atherosclerosis (hardening of the arteries), inflammation, and likely obesity and other metabolic diseases, new research suggests.The discovery was made by researchers at the University of Virginia School of Medicine in the context of how our bodies recognize and remove dying cells.
SLC Gene
&nb...
Source: St. Jude Children’s Research Hospital Dec 22, 2018 6 years ago
St. Jude Children's Research Hospital scientists have discovered a subset of helper T cells that may help to redefine understanding and treatment of chronic, debilitating inflammatory disorders.
The study focused on a family of helper T cells called Th17 cells. Th17 cells help to launch the immune response against fungal infection and other threats. These cells can also fuel the destructive i...
In a new study, Yale Cancer Center (YCC) scientists suggest that as the number of clinical trials in cancer immunotherapy grows exponentially, some caution should be exercised as we continue to better understand the biology of these new therapeutic targets. The findings are published today in the journal Cell.
Researchers around the world have been racing to create therapies that unleash th...
Source: Columbia University Irving Medical Center Dec 20, 2018 6 years ago
In a phase three clinical trial, a drug called sorafenib stopped progression of desmoid tumors for two years in 80 percent of patients who completed treatment, a significant increase in progression-free survival compared with placebo. (Progression-free survival is the length of time a patient lives without worsening of the disease).
There is no standard of care for patients with desmo...
Source: University Of Virginia Dec 19, 2018 6 years ago
Researchers at the University of Virginia School of Medicine have made a discovery about human papillomavirus (HPV) that could lead to new treatments for cervical cancer and other cancers caused by the virus.
HPV is responsible for nearly all cases of cervical cancer and 95 percent of anal cancers. It is the most common sexually transmitted disease, infecting more than 600 million people glo...
Source: University of Tennessee Health Science Center Dec 18, 2018 6 years ago
Scientists have identified a key player in blood pressure regulation and have shown that switching it off reduces blood pressure in mice.
Their study ends much uncertainty about the contribution this molecule makes to high blood pressure and could lead to the development of new drugs. High blood pressure affects millions worldwide and is a leading cause of heart attack and stroke.
Blood pressur...
Source: University Of Tasmania Dec 17, 2018 6 years ago
Diabetes has been tied to a number of complications such as kidney disease, but new research has found that older people with type 2 diabetes can also have more difficulties with thinking and memory.
During a five-year study, participants with diabetes showed a decline in verbal memory and fluency. Using MRI scans, researchers saw that the participants' brains were smaller at the star...
Source: Newcastle University Dec 16, 2018 6 years ago
Hope has emerged for patients with a serious type of bone marrow cancer as new research into a therapeutic drug has revealed improved outcomes and survival rates.
In the largest study of its kind, researchers at Newcastle University, UK, have led national research into the treatment of patients with newly diagnosed myeloma.
The results, published online today by The Lancet Oncolo...
Source: Rutgers University Dec 15, 2018 6 years ago
Scientists have taken an important step toward the goal of making diseased hearts heal themselves -- a new model that would reduce the need for bypass surgery, heart transplants or artificial pumping devices.
A team of Rutgers scientists, including Leonard Lee and Shaohua Li, have taken an important step toward the goal of making diseased hearts heal themselves -- a new model that would reduce ...
Source: Harvard Medical School Dec 14, 2018 6 years ago
The elderly suffer more serious complications from infections and benefit less from vaccination than the general population. Scientists have long known that a weakened immune system is to blame but the exact mechanisms behind this lagging immunity have remained largely unknown.
Now research led by investigators at Harvard Medical School suggests that weakened metabolism of immune T cells may be p...
Source: Mary Ann Liebert, Inc Dec 13, 2018 6 years ago
A new study has shown that HIV-infected men had lower median bone mineral density (BMD) scores at the hip compared to HIV-uninfected men, and all men who received testosterone had significantly greater BMD scores at the lumbar spine. Further, in HIV-infected men with virologic suppression testosterone was significantly associated with a higher BMD score at the lumbar spine, as reported in AID...
Vegetables and fruits found in lunches for students under the government-sponsored lunch programme are almost 100 percent contaminated with pesticides and 99 percent of the urine samples from students and teachers in four provinces were tested with organophosphate, a deadly toxic pesticide that attacks nervous system.
The above alarming findings were the result of a research jointly conducted by...
Source: University of Basel Dec 13, 2018 6 years ago
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth—this was discovered by researchers from the University of Basel's Biozentrum two years ago. In a follow-up study, recently published in Cell Reports, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used...
Source: Oswaldo Cruz Foundation, Brazil Dec 12, 2018 6 years ago
Current treatment options for the parasitic disease leishmaniasis are largely ineffective, expensive, and tend to be plagued by resistant parasites and side effects. Now, researchers reporting in PLOS Neglected Tropical Diseases have showed that a natural flavonoid is effective at treating Leishmania amazonensis infections.
Leishmaniasis is endemic to 98 countries and affect...
Source: University of Glasgow Dec 11, 2018 6 years ago
Kidney dialysis can cause short-term 'cerebral stunning' and may be associated with progressive brain injury in those who receive the treatment for many years. For many patients with kidney failure awaiting a kidney transplant or those not suitable for a transplant, dialysis is a life-saving treatment.
New research, led by the University of Glasgow and published today in the Journal Ame...
CAP or Community-acquired pneumonia disproportionately affects older people, with high rates of morbidity and mortality among the elderly. Although pneumococcal vaccines are routinely recommended for this population, fewer than 40% of adults age 60 and older get vaccinated. Thus, antibiotics are key to treating CAP in the elderly—and the earlier that antibiotic therapy starts, the bett...
Source: University of Birmingham Dec 09, 2018 6 years ago
The large scale systematic review published in The Cochrane Library as part of a Special Collection of Cochrane Systematic Reviews bringing together a vast body of research on the accuracy of tests used to diagnose skin cancer. The suite of eleven reviews was led by Dr Jac Dinnes at the University of Birmingham and supported by the Cochrane Skin Group and a team of over 30 researc...
Source: Northwestern University Dec 08, 2018 6 years ago
An extensive study from Northwestern Medicine psanning over two decades, reports that Men with inflammatory bowel disease have four to five times higher risk of being diagnosed with prostate cancer.
This is the first report to show men with inflammatory bowel disease have higher than average PSA (prostate-specific antigen) values, and this group also has a significantly higher risk o...
Source: University of Zurich Dec 07, 2018 6 years ago
The current situation shows that doctors are prescribing to even healthy people who don't suffer from a cardiovascular disease ,cholesterol-lowering drugs, known as statins, if they meet certain risk criteria. However, for years the use of statins for primary prevention has been hotly debated among experts. "Ultimately, this measure helps to prevent heart attacks or strokes in only a few ...
Samitivej Reaffirms Its Leadership in Mobile Health Innovations
Samitivej is expanding its innovative mobile health services, based on the hospital’s deep understanding of patient needs. Samitivej Mobile Health offers Samitivej Plus app, Line@Samitivej and Samitivej PACE to improve the patient experience. Mobile Health is now also offering Ward Tracking application to assist patients in pre...
Source: Washington University School of Medicine Dec 07, 2018 6 years ago
People with autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis are at high risk of developing cardiovascular disease, even though none of these conditions seem to target the cardiovascular system directly. Now, researchers at Washington University School of Medicine in St. Louis believe they have begun to understand the link between the two.
Researchers studying mice with a pso...
Source: journal of the American Academy of Facial Plastic and Reconstructive Surgery Dec 07, 2018 6 years ago
The topical retinoid tazarotene could be an efficacious and practical alternative to microneedling for treating atrophic postacne scarring, according to a new study.
In a prospective, randomized, split-face study of adults with postacne scarring, both treatments resulted in similar efficacy after 6 months, reported T.P. Afra, MD, and associates from the department of dermatology, venereo...
Source: University of Montreal Dec 07, 2018 6 years ago
A team of researchers at the Institute for Research in Immunology and Cancer (IRIC) at Université de Montréal has demonstrated that a cancer vaccine can work. Not only that, it could become an extremely effective, non-invasive and cost-effective cancer -fighting tool.
The team's work was published yesterday in Science Translational Medicine.The discovery repres...
Source: University of Tennessee Health Science Center, US. Dec 06, 2018 6 years ago
Scientists have identified a key player in blood pressure regulation and have shown that switching it off reduces blood pressure in mice.Their study ends much uncertainty about the contribution this molecule makes to high blood pressure and could lead to the development of new drugs. High blood pressure affects millions worldwide and is a leading cause of heart attack and stroke.
Blo...
Source: University of Maryland School of Medicine Dec 05, 2018 6 years ago
The Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) announced today the discovery that DnaK, a protein of the bacterium mycoplasma, interferes with the mycoplasma-infected cell's ability to respond to and repair DNA damage, a known origin of cancer.
Little or no mycoplasma DnaK DNA sequences were found associated with the tumor, which was ful...
Source: Scripps Research, US Dec 04, 2018 6 years ago
An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during aging, a study in the open-access journal eLife reports.
Protein aggregation causes several progressive age-related brain diseases, including amyotrophic lateral sclerosis, Alzheimer's, Parkinson's and prion disease. This study shows that minocycline prevents this bu...
Source: The National Centre for Cancer Research, US Dec 04, 2018 6 years ago
Immunotherapy, the strategy for triggering the patient's own immune system to attack cancer, is proving effective for more tumour types, although to varying degrees. In lung cancer, immunotherapy had proven to extend survival rates for only some variants of the disease. Now, an international clinical trial led by the oncologist Luis Paz-Ares has substantially increased the group of lung cancer...
A research team led by Tufts University engineers has developed a non-invasive method for detecting bladder cancer that might make screening easier and more accurate than current invasive clinical tests involving visual inspection of bladder. In the first successful use of atomic force microscopy (AFM) for clinical diagnostic purposes, the researchers have been able to identify signature features ...
Source: University of Chicago Medical Center Dec 03, 2018 6 years ago
An international phase-2 trial of a CAR-T cell therapy—to be published on-line Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego)—found that 52 percent of patients responded favorably to the therapy; 40 percent had a complete response and 12 percent had a partial response. One year later, 65 percent percent of those patients w...
Source: University Of Alabama at Birmingham Dec 02, 2018 6 years ago
Preclinical experiments by University of Alabama at Birmingham researchers suggest the cancer drugs vorinostat, belinostat and panobinostat might be repurposed to treat infections caused by human papillomaviruses, or HPVs.
HPV infections caused an estimated 266,000 deaths from cervical cancer worldwide in 2012, according to the World Health Organization. Routine screening by Pap smears or HPV D...
Source: University Of Montreal Dec 01, 2018 6 years ago
Of the 50 million people around the world infected with HIV, less than one per cent have immune systems strong enough to suppress the virus for extended periods of time. These special immune systems are known as "elite controllers." But how do they actually fight HIV? Canadian scientists think they've found an important clue.
TRIM5 Alpha protein
Working in collaboration with a team...
Source: University Of Zurich Nov 30, 2018 6 years ago
Stem cell transplantation is effective against leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients' healthy tissue—often with fatal consequences. Researchers at the University of Zurich have now identified a molecule that plays a key role in this process. Blocking this molecule could significantly improve the outcome of patients receivin...
Source: Northwell Health’s Feinstein Institute for Medical Research Nov 29, 2018 6 years ago
Scientists have uncovered that an emerging gene therapy for Parkinson's disease creates new circuits in the brain associated with improved motor movement. These findings, published today in Science Translational Medicine by Feinstein Institute for Medical Research Professor David Eidelberg, MD, and his team, explain the therapeutic mechanisms involved in the emerging Parkinson's ...
Source: Johns Hopkins University Of Medicine Nov 28, 2018 6 years ago
Researchers at Johns Hopkins have identified two patients with HIV whose immune cells behave differently than others with the virus and actually appear to help control viral load even years after infection. Moreover, both patients carry large amounts of virus in infected cells, but show no viral load in blood tests. While based on small numbers, the data suggest that long-term viral remission migh...
Source: Cedars-Sinai Medical Center Nov 27, 2018 6 years ago
A new study has identified a novel molecular driver of lethal prostate cancer, along with a molecule that could be used to attack it. The findings were made in laboratory mice. If confirmed in humans, they could lead to more effective ways to control certain aggressive types of prostate cancer, the second-leading cause of cancer death for men in the world.
Men whose prostrate cancer tumor...
Source: University of Minnesota Nov 26, 2018 6 years ago
A new study by University of Minnesota biomedical engineers shows how they stopped cancer cells from moving and spreading, even when the cells changed their movements. The discovery could have a major impact on millions of people undergoing therapies to prevent the spread of cancer within the body.
After targeting the "motors" that generate forces in cancer cells to move, the cancer ce...
Source: VIB (the Flanders Institute for Biotechnology) Nov 25, 2018 6 years ago
Scientists from the VIB-UGent Center for Inflammation Research identified the mechanisms by which the bacterial pathogen Clostridium difficile kills intestinal epithelial cells (IECs), thus destroying the protective mucosal barrier of the intestinal tract. The researchers demonstrate the physiological relevance of this process during infection and have published their findings in Nature Commu...
Source: American Academy of Neurology Nov 24, 2018 6 years ago
Eating leafy greens, dark orange and red vegetables and berry fruits, and drinking orange juice may be associated with a lower risk of memory loss over time in men, according to a study published in the November 21, 2018, online issue of Neurology, the medical journal of the American Academy of Neurology.
"One of the most important factors in this study is that we were able to researc...