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Source: COVID-19 Antibodies Jul 13, 2020 5 years ago
COVID-19 Antibodies: A new research led Scripps Research Institute has discovered a common molecular feature found in many of the human antibodies that neutralize SARS-CoV-2, the coronavirus that causes COVID-19.
The researchers reviewed data on nearly 300 anti-SARS-CoV-2 antibodies that their labs and others have found in convalescent COVID-19 patients over the past few months....
COVID-19 Vaccine: Maryland based Altimmune, Inc., a clinical-stage biopharmaceutical company, has reported positive results from the preclinical studies conducted in mice at the University of Alabama at Birmingham of its intranasal COVID-19 vaccine candidate, AdCOVID.
The research studies; a collaboration between the University of Alabama-Birmingham and Altimmune showed strong serum neutr...
Source: Thailand COVID-19 Jul 13, 2020 5 years ago
Thailand COVID-19: Thailand is reporting new COVID-19 cases from foreigners and Thais coming from Muslim countries like Pakistan, Egypt, UAE, Kuwait etc. Many local Thais are getting upset with the government for allowing flights to resume from these countries and are calling for a ban for all flights and arrivals from these countries.
In what is now becoming a major health scare that is ...
COVID-19 Drugs: A relatively large and detailed clinical trial performed by Japanese researchers has showed inconclusive data from Covid-19 patients treated with Fujifilm’s Avigan drug also known as favipiravir. Fujita Health University researcher Professor Dr Yohei Doi said that the drug led to improvement in patients treated early, compared to those who received delayed dose...
Source: China COVID-19 News Jul 13, 2020 5 years ago
China COVID-19 News: A prominent Chinese doctor from Renmin Hospital of Wuhan University who has been supplying us with research studies and information but on conditions of anonymity since the start of the outbreak has claimed to say that the situation in China is more dire that thought as he claims that millions of Chinese country wide are infected with the SARS-CoV-2 coronavirus but do no...
Source: COVID-19 Immunology Jul 13, 2020 5 years ago
COVID-19 Immunology: A new study by German researchers from Saarland University shows that there are higher levels of anti-SARS-CoV-2 T cells, which show significant alterations in the phenotype and function in COVID-19 patients.
Initial research had already shown that the SARS-CoV-2 coronavirus causes broad changes in cellular immune response, seen chiefly as lymphopenia, altera...
Source: COVID-19 Innovations Jul 13, 2020 5 years ago
COVID-19 Mask: Medical and Engineering Researchers from MIT and Harvard’s Brigham and Women’s Hospital have designed a new face mask that they believe could stop viral particles as effectively as N95 masks. Unlike N95 masks, the new masks were designed to be easily sterilized and used many times.
The masks are based on the shape of the 3M 1860 style of N95 masks, the type n...
Source: COVID-19 Cellular Therapy Jul 13, 2020 5 years ago
COVID-19 Cellular Therapy. Spanish researchers announced that a cellular therapy tested on 13 intubated patients with mechanical ventilation has shown to be efficient for the clinical improvement of critical cases of COVID-19.
The research which is the broadest published to date in these conditions, has been published in journal: The Lancet's EClinical Medicine, after proving that the...
Source: COVID-19 Research Jul 13, 2020 5 years ago
COVID-19 Research: Researchers from the department of molecular medicine at Scripps Research Institute - Florida in a new study have discovered that cholesterol saturation in host cells helps to facilitate viral entry of the SARS-CoV-2 coronavirus.
Their research findings were published on a preprint server but are yet to have been peer-reviewed. https://www.biorxiv.org/content/10.1101/20...
Hand Sanitizer Reaction: A report was published in the Oxford journal: Alcohol and Alcoholism in which a case study was highlighted involving Disulfiram-Ethanol reactions by hand-sanitizer usage. The case warn patients recovering from alcoholic addiction and are on the drug Disulfiram to be ware when using ethanol containing hand sanitizers. https://academic.oup.com/alcalc/article-abstract/55/4/34...
Source: COVID-19 Antibodies Jul 12, 2020 5 years ago
COVID-19 Antibodies: One of Boehringer Ingelheim’s research programs has uncovered unique 28 antibodies that the company plans to move into further testing.
A study team led by Cologne University Hospital and the German Center for Infection Research studied the antibody response to COVID-19 in 12 people who recovered from the virus, as well as immune cells from 48 healthy people col...
COVID-19 Meds: With more than 140 vaccine projects and more than 420 drug trials under way and governments in Europe and the United States investing billions of dollars in research, trials and manufacturing, there is concern that richer nations could scoop up promising medicines against the new coronavirus, leaving developing countries empty-handed.
Bill Gates, Billionaire philanthropist (wish h...
Remdesivir: Pharma giant Gilead Sciences wasted no time beginning testing of an inhaled formulation of its COVID-19 drug remdesivir for mild and less severe COVID-19 patients with the hope that the US FDA and Trump administration will support its approval again and buy up overpriced stocks once again with tax payers monies. We are not sure what basis the inhaled version of the drug will be approve...
Source: Cancer Treatments Jul 12, 2020 5 years ago
Cancer Treatments: Oncology researchers from Stanford University and Washington State University have demonstrated that a fatty acid called dihomogamma-linolenic acid, or DGLA, can be used to target and kill human cancer cells.
The research findings published in the journal: Developmental Cell, found that DGLA can induce ferroptosis in an animal model and in actual human cancer cells...
COVID-19 Latest: More than 55 European researchers from 13 research centers across Germany, Netherlands and Greece provide the first evidence for the use of whole blood transcriptomics to distinguish COVID-19 disease from other infections, and also to monitor and potentially predict disease outcomes. Such as approach helps further dissect molecular phenotypes and stratify COVID-19 patients, as wel...
Source: COVID-19 Research Jul 12, 2020 5 years ago
COVID-19 Research: European researchers from Universitair Ziekenhuis Leuven-Belgium, Karolinska Institutet-Sweden, Dresden University of Technology-Germany, University of Cambridge-UK and University of Oslo-Norway have in a new collaborative study shown that genes involved in severe SARS-CoV-2 coronavirus infection are expressed to a higher degree in older heart muscle cells or cardiomyocytes than...
Source: COVID-19 Virucides Jul 11, 2020 5 years ago
COVID-19 Virucides: Researchers from Duke-NUS Medical School In Singapore shows that Povidone-Iodine demonstrates rapid in vitro virucidal activity against sars-cov-2 coronavirus in a new study.
The research findings were published in the journal: Infectious Disease and Therapy Journal. https://link.springer.com/article/10.1007/s40121-020-00316-3
Povidone-iodine (PVP-I), which is highly ef...
Source: Thailand Medical News Jul 11, 2020 5 years ago
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Source: COVID-19 Aerosol Box Jul 11, 2020 5 years ago
COVID-19 Aerosol Boxes meant to protect doctors and nurses when they intubate COVID-19 patients may actually increase their exposure to airborne SARS-CoV-2 coronavirus particles according to a new Australian study.
The study findings are published in the journal: Anaesthesia,the official journal of the Association of Anaesthetists. https://onlinelibrary.wiley.com/doi/full/10.1111/an...
COVID-19 Latest: Emerging research from China shows that certain COVID-19 patients without a previous diagnosis of diabetes are showing abnormally high blood sugar and this is often associated with more than double the risk of death and also an increased risk of severe complications. One of the possible explanations for this phenomenon is that the endocrine system is being affected along wit...
COVID-19 News: Researchers from the University Of Basel have published a new study that focuses of the epidemiology of SARS-CoV-2 emergence amidst Community-Acquired Respiratory Viruses(CARVs) with implications of what we can expect in the coming winter.
The study traces how COVID-19 became the predominant cause of respiratory infection in the period from early January until the present. ...
New Viral Pneumonia:The Chinese embassy in Kazakhstan has warned of a deadly “unknown pneumonia” after the former Soviet republic reported a spike in pneumonia cases since June.The embassy that that is not the current SARS-CoV-2 coronavirus but stopped short of saying what it was.
The embassy said in a warning to Chinese citizens in the country, “The death rate of this disease ...
Source: COVID-19 Diagnostics Jul 10, 2020 5 years ago
COVID-19 Diagnostics: American researchers led by the Cedars-Sinai Medical Center and University Of Connecticut have developed highly specific and sensitive assays that could improve understanding of the antibody response in the COVID-19 disease and also help to determine the effectiveness of vaccines.
The new assays uncovered dynamic changes in the level of antibodies against the SARS-Co...
Source: U.S. Medical News Jul 10, 2020 5 years ago
US COVID-19 News: America posted 65,551 new COVID-19 cases in the last 24 hours, a record for a 24-hour period, according to a tally by Johns Hopkins University.
USA is the hardest-hit country in the world by the pandemic, has a total caseload of more than 3.22 million, with 135,018 deaths. (As of 10th July, 3am California,m Source Worldometer)
It was also reported that more ...
Source: COVID-19 Clinical Trials Jul 10, 2020 5 years ago
COVID-19 Clinical Trials: Medical researchers from the University of California San Diego School of Medicine have launched a clinical trial to assess the safety and efficacy of convalescent plasma to prevent COVID-19 after a known exposure to the virus.
Convalescent plasma therapy involves infusing patients with antibodies extracted from the blood of donors who have successfully...
Source: COVID-19 Clinical Trials Jul 10, 2020 5 years ago
COVID-19 Clinical Trials: Medical researchers are saying that low-dose radiation therapy seems to improve outcomes for COVID-19 patients. At least a dozen clinical trials are underway throughout the world to further explore the benefits. https://clinicaltrials.gov/ct2/results?cond=COVID-19&term=low-dose+radiation&cntry=&state=&city=&dist=
The latest two trial...
Source: COVID-19 Vaccines Jul 10, 2020 5 years ago
COVID-19 Vaccines: The U.S.National Institute of Allergy & Infectious Diseases (NIAID) has founded a new clinical trials network focused on enrolling volunteers in clinical trials for COVID-19 vaccines and monoclonal antibodies.
Various media have recently reported that sponsor companies are struggling to enroll patients in clinical trials for COVID-19 va...
Source: COVID-19 Controversies Jul 10, 2020 5 years ago
COVID-19 Controversies: Despite the fact that Pharmaceutical giant Gilead has huge resources and research facilities, it was never demonstrated that Remdesivir had any direct effects in terms of inhibiting the SARS-CoV-2 replication capability in vitro or vivo studies. The only things it had that made the Trump administration pass the FDA approval as a drug for COVID-19 was 'half-baked' st...
COVID-19 Drugs: Despite numerous studies showing that Lopinavir and Ritonavir are not effective to treat COVID-19, we still have numerous ignorant countries and doctors still using those drugs in their treatment protocols.
Now a new French study shows that older, critically ill patients with COVID-19 who received a combination of the antiretroviral medications lopinavir and ritonavir experienced ...
Source: COVID-19 Genomics Jul 09, 2020 5 years ago
COVID-19 Genomics: University Of Otago-New Zealand researchers studying the SARS-CoV-2 coronavirus has discovered that a particular binding site of virus targeting host microRNA miR197-5p has mutated more than 40 times since March and is now present in more than 75 percent of SARS-CoV-2 global isolates. The findings also have implications for cardiovascular issues.
The research findings w...
COVID-19 Drugs: There is now an increased demand for a variety of drugs to treat the growing variety of symptoms and conditions associated with COVID-19. One of which is the assortment of different types of neurological conditions. Just for one neurological category of symptoms which is delirium, BioXcel Therapeutics, which is based in Connecticut has developed a new drug called BXCL510.
...
COVID-19 Drugs: R-Pharm, a Russian pharmaceutical company has secured regulatory approval for the use of its antiviral drug Coronavir, to treat patients suffering from Covid-19. The company released the announcement today to Russian media.
The regulatory approval comes after a clinical trial in mild to moderate Covid-19 patients showed that the drug is highly effective in blocking replica...
Source: COVID-19 Genomics Jul 09, 2020 5 years ago
COVID-19 Genomics: Swiss Researchers from the Institute of Molecular Biology and Biophysics-Zurich, University of Bern and Institute of Virology and Immunology-Bern have discovered the detailed functional process by which the SARS-CoV-2 coronavirus NSP1 Protein Inhibits Host Translation.
Their study published in a preprint server shows that the 5’ end of the RNA molecule is ca...
Source: COVID-19 Disinfectants Jul 09, 2020 5 years ago
COVID-19 Disinfectants: The American Environmental Protection Agency (EPA) just approved two disinfection sprays that can kill severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19), on surfaces. The agency gave the green light to Lysol Disinfectant Spray, and Lysol Disinfectant Max Cover Mist, as two products that can effectively kil...
Source: COVID-19 Nutrition Jul 09, 2020 5 years ago
COVID-19 Nutrition: A new but intriguing European study involving the collaboration of 13 research centers and universities in Germany, Spain, Portugal, Franca and Switzerland suggests that COVID-19 mortality rates are likely to be lower in countries where diets are rich in fermented vegetables.
Though the study is published on a preprint server, it is currently being peer-reviewed by a f...
Source: COVID-19 Diagnostics Jul 09, 2020 5 years ago
COVID-19 Diagnostics: Researchers from the University of Exeter have developed a revolutionary new device that could allow health professionals to accurately test patients' antibody response to COVID-19 in as little as seven minutes.
The new pioneering COVID-19 Triple Antibody Test has been produced by the University of Exeter spin-out company Attomarker Ltd and is set to spearhead th...
COVID-19 Alert: Medical researchers from Cedars-Sinai Medical Center, Michigan Medicine and UCLA Fielding School of Public Health have found an association between proton pump inhibitors (PPIs) and risk of COVID-19 in an observational study of more than 53,000 Americans.It was found that PPIs usage was linked with a higher risk for COVID-19.
This places the usage of PPIs for heartburn and gastric...
Source: COVID-19 Antibodies Jul 08, 2020 5 years ago
COVID-19 Antibodies: Researchers from Tulane University-New Orleans, University of Illinois-Chicago and University of Georgia have created a synthetic antibody that on mouse models demonstrated to neutralize the SARS-CoV-2 coronavirus. This could help prevent infection as well as treat COVID-19 in those who already have it.
Typically the SARS-CoV-2 coronavirus, gains entry into cells...
Source: COVID-19 Research Jul 08, 2020 5 years ago
COVID-19 Research: German researchers from Max Planck Institute, Frankfurt Institute for Advanced Studies and the Institute of Biophysics, Goethe University-Frankfurt have conducted a news study on the structural dynamics of the SARS-CoV-2 spike protein and have identified epitopes that could be possible immune targets for the development of vaccines or other therapeutics.
The resear...
Source: COVID-19 Neurology Jul 08, 2020 5 years ago
COVID-19 Neurology: German researchers from Charité - Universitätsmedizin Berlin have shown that the neurological symptoms observed in some COVID-19 patients may be caused by autoantibodies targeting the brain.
The research team says that although some autoantibodies still need to be identified, they may at least partly explain the multiple organ disease that can occur in COVI...
COVID-19 Drugs: Medical researchers from Queensland University of Technology and Oxford University are working in collaboration to begin human clinical trials of inhaled corticosteroids, commonly used for asthma patients, on patients with COVID-19. The researchers believe that this could be useful for patients with the novel coronavirus infection.
Research has shown that some corticosteroids,&nbs...
Source: COVID-19 Innovations Jul 08, 2020 5 years ago
COVID-19 Innovations: Experts from the University of Houston, in collaboration with a private company called Medistar, have designed a "catch and kill" air filter that can trap the coronavirus responsible for COVID-19, killing it instantly.
Dr Zhifeng Ren, director of the Texas Center for Superconductivity at UH, collaborated with Monzer Hourani, CEO of Medistar, a Houston-based...
Source: COVID-19 Vaccine Updates Jul 08, 2020 5 years ago
COVID-19 Vaccine Updates: Maryland based Biotech company Novavax announced that it has been awarded US$1.6 billion toward late-stage clinical trials and large-scale manufacturing to produce 100 million doses of its COVID-19 vaccine starting this year through the Trump’s administration “Operation Warp Speed” program.
The new funding will enable Novavax to complete la...
Source: COVID-19 Neurology Jul 08, 2020 5 years ago
COVID-19 Neurology: A new study by University College London (UCL) and University College London Hospitals (UCLH) indicate that more neurological conditions are being manifested in COVID-19 patients. Besides delirium, brain inflammation, stroke and nerve damage, a large number of patients are now shown to be inflicted with ADEM or Acute Disseminated Encephalomyelitis and its prevalence is gr...
Source: Guillain-Barre Syndrome And COVID-19 Jul 08, 2020 5 years ago
Guillain-Barre Syndrome: A new peer-reviewed study published in the Journal of Clinical Neuromuscular Disease by researchers from Department of Neurology and Neuroscience Institute, Allegheny General Hospital Pittsburgh, Pennsylvania show that COVID-19 is linked with Guillain-Barre Syndrome. https://journals.lww.com/jcnmd/FullText/2020/06000/Novel_Coronavirus__COVID_19__Associated.7.aspx
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Source: COVID-19 Clinical Care Jul 08, 2020 5 years ago
COVID-19 Clinical Care: A new study by researchers from Boston Children’s Hospital warns about how and when type III Interferons should be used in the treatment of COVID019 as using it in later stages of severity can do more harm.
The research findings were published in the journal: Science. https://science.sciencemag.org/content/early/2020/06/10/science.abc3545
The human imm...
Otolaryngology: A new study published in the Journal of Medical Genetics shows that a common inherited genetic variant is a frequent cause of deafness in adults with implications that many thousands of people are potentially at risk.
For a long time deafness in adults is known to be inherited. But, unlike childhood deafness, the genetic causes largely remain a mystery, say ...
Source: COVID-19 Research-Liver Fibrosis Jul 07, 2020 5 years ago
COVID-19 Research: According to researchers in Spain, middle-aged COVID-19 patients showing signs of advanced liver fibrosis, as estimated by the Fibrosis Index Based on 4 Factors (FIB-4), are at greater likelihood of requiring mechanical ventilation.
Dr Luis Ibanez-Samaniego from the Hospital General Universitario Gregorio Maran, in Madrid who is the lead researcher said that not m...
Source: COVID-19 Warnings- Captopril Jul 07, 2020 5 years ago
COVID-19 Warnings: A US based study involving researchers from University of Missouri Kansas City School of Pharmacy, Kansas State University and North Carolina State University has found that the high blood pressure drug Captopril to be associated with a higher rate of pulmonary adverse reactions in patients with diabetes than that of other ACE inhibitors or angiotensin receptor blockers (ARBs).
...
Source: COVID-19 Seroprevalence Jul 07, 2020 5 years ago
COVID-19 Seroprevalence: The Spanish ENE-COVID national seroprevalence study concludes that 5% of its population has antibodies. This percentage has hardly changed in the three waves of which the study consists: in the first it was estimated at 5% and in the second and third it was 5.2%, results that confirm that, despite the great impact of the pandemic in Spain, the figures are not high, which r...
Source: COVID-19 Case Study Jul 07, 2020 5 years ago
COVID-19 Case Study: Numerous patients with severe COVID-19 remain unresponsive after surviving critical illness. Medical Researchers from Massachusetts General Hospital (MGH) presents a case in which a patient with severe COVID-19 who, despite prolonged unresponsiveness and structural brain abnormalities, demonstrated functionally intact brain connections when functional MRI was used and we...
Source: COVID-19 Research Jul 07, 2020 5 years ago
COVID-19 Research: In a new study by researchers from US NIH, Columbia University and John Hopkins University, it has been shown that the SARS-CoV-2 coronavirus is proving itself to be an elusive foe, evading immune surveillance while instigating hyper-inflammatory responses that eventually destroy the host in a significant minority of cases. The study reports the role of pH in helping the virus e...
Source: COVID-19 Vaccine News Jul 07, 2020 5 years ago
COVID-19 Vaccine News: Biotech manufacturing company-Emergent BioSolutions, based in Maryland, entered a five-year manufacturing services deal with Janssen Pharmaceutical, a Johnson & Johnson company, to manufacture J&J’s Ad26.COV2-S COVID-19 vaccine. Emergent will handle contract development and manufacturing (CDMO) services in a deal that is valued at ...
Source: COVID-19 Antibodies Jul 07, 2020 5 years ago
COVID-19 Antibodies: New York based Regeneron Pharmaceuticals announced its double-antibody cocktail against COVID-19 is advancing into Phase III studies, less than a month after the start of its first clinical trial, with preliminary data from one study expected to be reported later this summer.
Regeneron's Biotech Plant
The biotech company said it is proceeding with clinical develop...
Source: COVID-19 Medical Devices Jul 07, 2020 5 years ago
COVID-19 Medical Devices: To date, emerging studies suggests that COVID-19 patients are at a higher risk of stroke and promptly diagnosing and treating such patients is a priority in hospitals across the world.
Furthermore, identifying which COVID-19 patients are at increased risk of developing a stroke is also important, and may help with preemptive treatment and monitoring.
Los A...