2021 Peer Reviewed Study Warning That COVID-19 Can lead To Pancreatic Adenocarcinoma Seems To Be Holding True As Pancreatic Cancer Cases Rise!
COVID-19 News - Pancreatic Cancer Jun 21, 2023 1 year, 5 months, 3 days, 19 hours, 49 minutes ago
Pancreatic Cancers, Liver Cancers, Colorectal Cancers, Neck And Throat Cancers, Brain Cancers Are All Expected To Rise!
COVID-19 News: While the risk that SARS-CoV-2 infections or exposure to the spike proteins of the virus in any form can lead to various cancers are being withheld by those controlling the COVID-19 narratives and are not covered by many mainstream media, the big pharma corporations and biotech companies are already preparing for huge deluge in cancer cases including pancreatic cancer.
https://finance.yahoo.com/news/pancreatic-cancer-drugs-global-market-020000921.html
https://www.marketwatch.com/press-release/insights-into-the-global-pancreatic-cancer-diagnostic-market-2023-2030-estimated-worth-of-usd-94112-million-and-growth-rate-of-73-2023-06-16
https://www.fortunebusinessinsights.com/pancreatic-cancer-treatment-market-101989
https://www.stratviewresearch.com/2265/Pancreatic-Cancer-Drugs-Market.html
In fact, the pharma companies had already projected that more aggressive forms of metastatic pancreatic cancer were expected to increase from 2020 onwards!
https://www.delveinsight.com/report-store/metastatic-pancreatic-cancer-mpc-market
Studies are already warning of an increase of the incidence of early onset pancreatic cancer among younger adults!
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00039-0/fulltext
In the United States, it is being conservatively projected that in 2023, about 64,000 individuals will be diagnosed with pancreatic cancer and about 50,000 people will die from pancreatic cancer in 2023!
https://www.precedenceresearch.com/pancreatic-cancer-market#:~:text=Additionally%2C%20in%20United%20States%2C%20Cancer,will%20die%20of%20pancreatic%20cancer.
These figures are expected to rise exponentially in the coming years!
While Thailand Medical News in our previous
COVID-19 News coverages had warned about increasing pancreatitis as a result of SARS-CoV-2 infections, it should be noted that chronic inflammation in the pancreas as a result of pancreatitis can also be a contributing cause to the rise of cancer!
gt;
https://www.thailandmedical.news/news/warning-incidences-of-acute-pancreatitis-as-a-result-of-sars-cov-2-infections-rising
https://www.sciencedirect.com/science/article/pii/S1535610811001899
https://pubmed.ncbi.nlm.nih.gov/20510834/
https://www.frontiersin.org/articles/10.3389/fphys.2013.00415/full
In Silico Study Shows That SARS-CoV-2 Infections Lead To Increased Risk Of Pancreatic Cancer And Also Progression Of Existing Pancreatic Cancer Malignancies!
However, a very important study published in 2021 by researchers from Iran and United Kingdom warned that SARS-CoV-2 infections similar to SARS1 infections could increase the risk of pancreatic adenocarcinoma.
https://www.nature.com/articles/s41598-021-92068-4
Strangely no mainstream media paid any focus on this warning!
The study team researchers delved into the wealth of available data, selecting relevant datasets from the GEO database. By identifying differentially expressed genes among various groups, including SARS-CoV, SARS-dORF6, SARS-BatSRBD, and H1N1, they sought to uncover significant gene expression changes associated with SARS-CoV-2 infection.
The study focused on genes PTEN, CREB1, CASP3, and SMAD3, which are known to be involved in increasing the risk of cancer, particularly in pancreatic adenocarcinoma.
Through molecular function analysis, researchers discovered that the upregulated genes were primarily associated with "double-stranded RNA binding," while the downregulated genes were linked to actin-binding. These findings hold profound implications, as alterations in RNA-binding proteins have been shown to play a crucial role in tumorigenesis. Similarly, imbalances in actin-binding proteins have been associated with various cancers, indicating their potential involvement in cancer development following SARS-CoV-2 infection.
Utilizing protein-protein interaction network analysis and Cytoscape, researchers identified four key genes as hub genes: PTEN, CREB1, CASP3, and SMAD3. These genes have been implicated in critical cellular processes and have demonstrated a significant impact on cancer development.
Notably, analysis of the TCGA database revealed a notable upregulation of these genes in pancreatic adenocarcinoma.
Given the high expression of ACE2 receptors, the main entry point for SARS-CoV-2, on pancreatic cells, the increased risk of pancreatic cancer following infection becomes a significant concern.
The intricate mechanisms by which viruses contribute to cancer development have been extensively studied. These mechanisms encompass the degradation of vital cell oncogenes, induction of genomic instability, alteration of miRNA expression levels, disruption of cell-cell contact inhibition, and the induction of oxidative stress. The interplay of these factors can lead to carcinogenesis following viral infections, including SARS-CoV-2.
While the experimental data regarding the carcinogenicity of SARS-CoV-2 is limited, the findings of this study underscore the need for further research.
Investigating the association between COVID-19 infection and different forms of cancer can lead to critical insights into the potential risks and long-term consequences of the disease.
Already with data showing that not only pancreatic cancer but various other cancers also increasing, it is important that more urgent studies are dedicated towards this area as the rise of cancer cases including pancreatic cancer can become a major burden on the public healthcare infrastructure.
Post COVID individuals should also make it a point to go for regular cancer and other health screenings considering the various risk that exposure to the SARS-CoV-2 creates.
For the latest
COVID-19 News, keep on logging to Thailand Medical News.
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