A High Neutrophil Count And High Mean Platelet Volume (MPV) Increases Risk of Angina Attacks In COVID-19 Individuals With Existing Cardiovascular Issues
COVID-19 News - Risk Of Angina Attacks May 29, 2023 1 year, 5 months, 3 weeks, 3 days, 11 hours, 51 minutes ago
COVID-19 News: Angina, a type of chest pain caused by reduced blood flow to the heart, is a symptom of coronary artery disease. With the ongoing COVID-19 pandemic, researchers have been investigating the impact of the virus on individuals with pre-existing conditions. A recent study conducted at the Fourth Affiliated Hospital of China Medical University and Shenyang Fourth People's Hospital in China has shed light on the association between COVID-19 infection, blood components, and the risk of angina attacks in individuals with stable angina pectoris.
Understanding the Relationship
Previous studies and
COVID-19 News reports have indicated that patients with cardiovascular disease who contract COVID-19 have worse outcomes and a higher mortality risk. The mortality rate among COVID-19 patients with cardiovascular disease is significantly higher than that of individuals with underlying diabetes or chronic respiratory diseases. In light of these findings, the study team aimed to investigate the potential connection between COVID-19 and stable angina pectoris, offering valuable insights for clinical practice.
Research Methodology
The study included 83 patients with stable angina pectoris and COVID-19, along with 49 patients with stable angina pectoris alone as a control group. The data collected encompassed various parameters, including age, sex, clinical symptoms, complications, electrocardiographic findings, blood biochemistry, neutrophil count, lymphocyte count, platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), mean platelet volume-to-lymphocyte ratio (MPVLR), myocardial enzymes, and muscle calcium.
Key Findings
The study findings showed that COVID-19 patients with stable angina pectoris group had a significantly higher neutrophil count, mean platelet volume, lymphocyte count, and platelet-to-lymphocyte ratio compared to the control group. Furthermore, within the COVID-19 plus stable angina pectoris group, the individuals who experienced angina attacks exhibited significantly higher platelet count, neutrophil count, mean platelet volume, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume-to-lymphocyte ratio than those who did not experience such attacks.
The Risk Factors
Univariable logistic regression analysis identified several risk factors for angina attacks in patients with COVID-19 and stable angina pectoris, including neutrophil count, lymphocyte count, platelet count, PLR, MPVLR, NLR, and mean platelet volume. Multivariable logistic regression analysis further confirmed that the neutrophil count and mean platelet volume were independent risk factors for angina attacks in this population.
Implications and Potential Mechanisms
The findings of this study suggest that individuals with COVID-19 and stable angina pectoris have a higher risk of angina attacks if they have elevated neutrophil counts and mean platelet volumes. These results could help clinicians identify patients at increased risk and provide targeted interventions to mitigate the impact of angina attacks.
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The study also highlights the potential link between COVID-19 infection and coronary ischemia, possibly mediated by the immune response, inflammation, and hematological abnormalities induced by the virus. It is theorized that COVID-19's systemic inflammation and cytokine storm can trigger coronary vasospasm, microthrombosis, and subsequent angina attacks. However, further research is needed to fully understand the underlying mechanisms.
Conclusion
In conclusion, this study contributes to our understanding of the relationship between COVID-19 infection, blood components, and the risk of angina attacks in individuals with stable angina pectoris (AP). The findings highlight the potential role of high neutrophil count and high mean platelet volume (MPV) as risk factors for acute ischemia in COVID-19 patients with stable AP.
The COVID-19 pandemic has posed significant challenges to global healthcare systems, with cardiovascular complications being a major concern. Patients with pre-existing cardiovascular conditions, such as stable AP, are particularly vulnerable to adverse outcomes when infected with COVID-19. Understanding the underlying mechanisms and identifying specific risk factors can help guide clinical management and improve patient outcomes.
The study findings were published in the peer reviewed Chinese Medical Journal.
https://journals.lww.com/cmj/Fulltext/9900/Risk_factors_in_blood_for_attacks_of_angina_in.598.aspx
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