Are The Spawns From The XBB.2.3 Sub-lineage Aka The 'Trans Variant' Such As XBB.2.3.2, XBB.2.3.5 Evolving To Cause T Cell Damage Similar To HIV?
COVID-19 News - XBB.2.3 Apr 27, 2023 1 year, 6 months, 3 weeks, 4 days, 11 hours, 38 minutes ago
COVID-19 News: Many from a small segment of the general population who are still smart enough to be paying attention to what is developing in terms of the COVID-19 pandemic are more engrossed in the XBB.1.16 sub-lineage (Arcturus) and some of its newer spawns such:
-XBB.1.16.1 (defining mutation-S:T547I)
-XBB.1.16.1.1 designated as FU.1 (defining mutation-T3802C)
-XBB.1.16.1.2 designated as FU.2 (defining mutation-C8692T)
-XBB.1.16.2 (defining mutations ORF3a:V13L, ORF1a:P926H
-XBB.1.16.3 (defining mutation A2893C)
Pic Credit: Getty
However, we at Thailand Medical News feel that the onslaughts by the XBB.1.16 and its spawns will also be short-lived in many geolocations similar to the XBB.1.5 sub-lineage and will only wreak havoc with those in the vulnerable groups (aged, obese, immunocompromised, those with existing comorbidities and those with certain genetic makeups) irrespective of them possessing so called hybrid immunity or having received the boosters. Past
COVID-19 News coverages have showed that the XBB.1.5 was only short-lived and with not much disease severity in the otherwise health and younger populations.
However, in terms of the long-term health complications and long COVID manifestations, we can expect more serious implications from the XBB.1.16 onslaught and the breakthrough infections it causes for the rest of the population.
It is very clear that all the new XBB-sub-lineages are evolving rapidly and spawning mutations at an unprecedented phase to evade all forms of immunity ie immunity from previous infections, induced immunity from vaccines and boosters and even remaining T Cell immunity!
These new sub-lineages besides being highly transmissible and having growth advantages are also better adapted for viral persistence and although many among the more younger and healthy segments are reporting short-lived mild symptoms upon infection with these sub-lineages such as the XBB.1.16, we can expect much more serious long term health complications and the burden from Long COVID will be more apparent. Some are trying to distort the long COVID narratives by making claims and even using manipulated studies to claim that the Omicron variants and the usage of boosters reduces the risk of Long COVID!
We at Thailand Medical News however are warning that the next onslaughts that will be lead by the newer emerging ‘woke’ XBB sub-lineages lead by the XBB.2.3 sub-lineage aka The Trans Variant and its ‘ugly’ spawns will be more worrisome.
We have reasons to speculate that the newer spawns of the XBB.2.3 sub-lineage such as XBB.2.3.2 aka the Dylan Mulvaney variant, the XBB.2.3.3 aka Lia Thomas variant, the XBB.2.3.4 aka the Jeffrey Marsh variant, XBB.2.3.5 aka the Zooey Zephyr variant and the XBB.2.3.6 aka the Thomas Jay White (Tara) variant will not only be more serious due these wretched sub-lineages being more vicious and pathogenic besides being more transmissible, but the many mutations being seen on the ORF1a and even ORf1b proteins are likely to not only further impair immune responses b
ut will also cause damage to both CD4 and CD8 T cells via a multiple of ways. Further urgent research is needed on this to validate our speculations.The arising damage is likely to be far worse than that seen in HIV or AIDs!
https://cov-spectrum.org/explore/India/AllSamples/Past6M/variants?nextcladePangoLineage=XBB.2.3&
https://cov-spectrum.org/explore/India/AllSamples/Past6M/variants?nextcladePangoLineage=XBB.2.3.2&
https://cov-spectrum.org/explore/India/AllSamples/Past6M/variants?nextcladePangoLineage=XBB.2.3.3&
https://cov-spectrum.org/explore/India/AllSamples/Past6M/variants?nextcladePangoLineage=XBB.2.3.4&
https://cov-spectrum.org/explore/India/AllSamples/Past6M/variants?nextcladePangoLineage=XBB.2.3.5&
In fact more attention and studies are urgently required about the newer XBB sub-lineages including the XBB.2.4, , XBB.2.5, XBB.3, XBB.4, XBB.5, XBB.6 and XBB 8 sub-lineages and their spawns.
We envisage that while the next new onslaught lead by the XBB.2.3 sub-lineage aka the 'Trans variants' especially its spawns will also only initially cause havoc among the vulnerable groups irrespective of vaccine or immunity status, the general population while might initially be spared with a mild infection will end up in more serious health conditions and even be at risk of higher mortality weeks after due to a variety of conditions as a result of rapid depletion of their CD4 and also CD8 T Cells. Their conditions will be far worse than HIV and also the risk from secondary opportunistic infections will be extremely high in them!
While we are only speculating here, urgent research is needed to verify our claims.
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COVID-19 News, keep on logging to Thailand Medical News.
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