Article In Peer Reviewed Journal: Frontiers In Immunology Claims There Could Be Unwanted Genes In The Current COVID-19 Jabs! This Needs To be Urgently Verified!
Source: COVID-19 Research Feb 08, 2022 2 years, 9 months, 2 weeks, 3 hours, 48 minutes ago
This is getting worrisome and experts and fact-checkers need to verify if there is any truth in an article published in the peer reviewed journal: Frontiers In Immunology that claims there could be unwanted or hidden genes in the current COVID-19 jabs!
The article by researchers from University of Cambridge-United Kingdom and the University of Ostrava-Czechia claim that there could be hidden or unwanted genes in the current COVID-19 jabs and certain adverse effects could actually be due to these genes!
https://www.frontiersin.org/articles/10.3389/fimmu.2022.801915/full
As a result of the fast-global spreading of the SARS-CoV-2 virus and its ever-emerging variants, prevention and treatment options are direly needed in order to control infection-related morbidity, mortality, and economic losses.
Though drug and inactivated and attenuated virus jab development can require significant amounts of time and resources, DNA and RNA jabs offer a quick, simple, and cheap treatment alternative, even when produced on a large scale.
The SARS-Cov-2 spike protein, which has been shown as the most antigenic SARS-CoV-2 protein, has been widely selected as the target of choice for DNA/RNA jabs.
COVID-19 jab campaigns have reported high jab rates and protection, but numerous unintended effects, ranging from muscle pain to death, have led to concerns about the safety of RNA/DNA jabs.
Alarmingly, in parallel to these studies, several open reading frames (ORFs) have been found to be overlapping SARS-CoV-2 accessory genes, two of which, ORF2b and ORF-Sh, overlap the spike protein sequence.
https://pubmed.ncbi.nlm.nih.gov/32906143/
https://pubmed.ncbi.nlm.nih.gov/34171305/
https://pubmed.ncbi.nlm.nih.gov/34339929/
Hence, the presence of these, and potentially other ORFs on SARS-CoV-2 DNA/RNA jabs, could lead to the translation of undesired proteins during jabs.
The study team discusses the translation of overlapping genes in connection with DNA/RNA jabs.
Two mRNA jab spike protein sequences, which have been made publicly-available, were compared to the wild-type sequence in order to uncover possible differences in putative overlapping ORFs.
https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273
Notably, the Moderna mRNA-1273 jab sequence is predicted to contain no frameshifted ORFs on the positive sense strand, which highlights the utility of codon optimization in DNA/RNA jab design to remove undesired overlapping ORFs.
Since little information is available on ORF2b or ORF-Sh, the
COVID-19 Jabs study team used structural bioinformatics techniques to inves
tigate the structure-function relationship of these proteins.
The presence of putative ORFs on DNA/RNA jab candidates implies that overlapping genes may contribute to the translation of smaller peptides, potentially leading to unintended clinical outcomes, and that the protein-coding potential of DNA/RNA jabs should be rigorously examined prior to administration.
Worryingly newly predicted ORFs on the Pfizer BNT162b2 jab mRNA sequence highlight the fact that codon optimization can also lead to the spontaneous generation of novel overlapping ORFs. Of interest is the observation that allowing detection of alternative initiation codons increased the number of predicted ORFs on the positive sense strand of the wild-type (11 to 19 ORFs), BNT162b2 (8 to 25), and mRNA-1273 (0 to 4) sequences. Experimental validation and in-depth genomic analysis and annotations, however, are required to validate the presence or absence of these and other ORFs on the spike protein jab candidate sequences.
The study team concluded, “Although the wild-type SARS-CoV-2 spike protein nucleotide sequence has been found to code for translated overlapping genes, ORF detection predictions on the sequences of two mRNA jabs reveal that codon optimization has the potential to disrupt non-specific translation. Additional overlapping ORFs can arise during codon optimization; thus, the final sequences should nevertheless be scrutinized for their protein-coding potential. In the case of DNA jabs and viral vectors, the negative-sense strand should also be checked for its protein-coding potential. Additionally, as variants of concern become known and jabs are altered to include them, the spontaneous generation of ORFs should be re-assessed. Many precautionary steps have been taken to ensure the safety and efficacy of the mRNA jabs, including nucleoside modification to reduce inflammatory responses and 5’-capping and polyadenylation tail length optimization to increase mRNA stability and translation. Thus, the inclusion of additional steps to ensure that jab sequences code solely for the intended protein may also lead to better health and safety outcomes. Measures to check for other adverse effects on host cells, such as those resulting from potential interactions of jab nucleotide sequences with host RNAs or proteins, or the host microbiome may be increase efficacy and safety as well. More in-depth investigation of these delivery methods may reveal aspects that should be further refined to safeguard against unintended side effects.”
Experts and fact-checkers urgently need to review this paper and assess if there is any truth to this paper or it is simply fear mongering!
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