BREAKING! COVID-19 News: SARS-CoV-2 Infections Lead To Increased Risk Of Breast Cancer, Recurrence Of Breast Cancer And Also Breast Cancer Metastasis!

COVID-19 News: While the death rates from breast cancer has been declining over the last few years due to better and early screening along with early medical intervention, the incidence of breast cancer is growing exponentially over the world in the last two years and is raising alarms! Even worse, the number of younger adults below the age of 50 developing breast cancer is also increasing along with other cancers!
https://news.harvard.edu/gazette/story/2022/09/researchers-report-dramatic-rise-in-early-onset-cancers/
 
https://www.breastcancer.org/facts-statistics
 
https://www.wcrf.org/cancer-trends/breast-cancer-statistics/
 


A few peer reviewed studies that have not been covered by any mainstream media and not talked much about as a result of a concerted effort by those controlling the COVID-19  narratives to suppress these studies shows worrisome effects of the toxic SARS-CoV-2 proteins that one can get exposed to either via natural infections or via ‘mRNA prophylactics’ that individuals have been forced or misled to take, in terms of increasing the risk of breast cancer, causing the recurrence of breast cancer and also promoting breast cancer metastasis! An interesting point that Thailand Medical News would like to add is that, the newer breast cancers being caused by as a result of exposure to the SARS-CoV-2 virus are more aggressive and have accelerated progression….so much so that the efforts that the medical community has achieved in the last few years to lower the death rates from breast cancer will likely be overturned!
 
In an earlier COVID-19 News coverage about the possible increase of incidences head and neck cancer as a result of SARS-CoV-2 infections, we had already detailed many other studies indicating how the SARS-CoV-2 virus creates an environment that is suitable for cancer development and progression as a result of many factors including damaging and decreasing NK cells and various other critical T Cells, downregulation of tumor suppressive genes like p53, upregulation of various oncogenic genes and also persistent inflammation.
https://www.thailandmedical.news/news/covid-19-news-will-sars-cov-2-infections-ultimately-lead-to-an-increased-incidence-of-head-and-neck-cancers
 
SARS-CoV-2 M Protein Facilitates Malignant Transformation Of Breast Cancer Cells
 
A Japanese study conducted by researchers and oncologists from the University of Tsukuba-Japan in the second quarter of 2022 alarmingly showed that the M protein of the SARS-CoV-2 coronavirus was able to facilitate facilitates malignant transformation of breast cancer cells!
 
The study team investigated the impact of SARS-CoV-2 proteins on breast cancer cells (BCC).&l t;br />  
Shockingly, the study findings showed that SARS-CoV-2 M protein induced the mobility, proliferation, stemness and in vivo metastasis of a triple-negative breast cancer (TNBC) cell line, MDA-MB-231, which are involved in the upregulation of NFκB and STAT3 pathways.
 
In addition, compared to MDA-MB-231 cells, the hormone-dependent breast cancer cell line MCF-7 showed a less response to M protein, with the protein showing no effects of promoting proliferation, stemness, and in vivo metastasis.
 
It was noted that coculture with M protein-treated MDA-MB-231 cells significantly induced the migration, proliferation, and stemness of MCF-7 cells, which are involved in the upregulation of genes related to EMT and inflammatory cytokines.
 
Worryingly, this implies that SARS-CoV-2 infection might actually promote the ability of aggressive BCC to induce the malignant phenotypes of the other non-aggressive BCC.
 
The study findings were published in the peer reviewed journal: Frontiers In Oncology.
https://www.frontiersin.org/articles/10.3389/fonc.2022.923467/full
 
COVID-19 Is A Potential Driver Of Immune-Mediated Breast Cancer Recurrence.
In late 2020, already Italian researchers from Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome- Italy had discovered that COVID-19 could be a driver of immune-mediated breast cancer recurrence!
 
According to the study team, COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (NETs). The presence of NETs and of a pro-inflammatory microenvironment may therefore promote breast cancer reactivation, increasing the risk of pulmonary metastasis.
 
Their study findings were published in the peer reviewed journal: Breast Cancer Research.
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01360-0
 
Hyperglycosylated Spike Of Certain SARS-Cov-2 Variants Induces Breast Cancer Metastasis
 
A study by in late 2021 led by researchers from Institute of Biomedical Sciences, Academia Sinica-Taiwan and the Graduate Institute of Biomedical Sciences and Research Center for Cancer Biology, China Medical University-Taiwan found that hyperglycosylated spike of certain SARS-COV-2 variants induces breast cancer metastasis!
 
According to the study team, while SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19), growing evidence suggests SARS-CoV-2 also exacerbates many chronic diseases, including cancers.
 
As mutations on the spike protein (S) emerged as dominant variants that reduce vaccine efficacy, little is known about the relation between SARS-CoV-2 virus variants and cancers. Compared to the SARS-CoV-2 wild-type, the Gamma variant contains two additional NXT/S glycosylation motifs on the S protein. The hyperglycosylated S of Gamma variant is more stable, resulting in more significant epithelial-mesenchymal transition (EMT) potential. SARS-CoV-2 infection promoted NF-κB signaling activation and p65 nuclear translocation, inducing Snail expression. Pharmacologic inhibition of NF-κB activity by nature food compound, I3C suppressed viral replication and Gamma variant-mediated breast cancer metastasis, indicating that NF-κB inhibition can reduce chronic disease in COVID-19 patients.
 
Their study findings were published in the peer reviewed American Journal Of Cancer Research.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569360/
 
It should be noted that some of the newer emerging subvariants and sub-lineages also contain additional NXT/S glycosylation motifs on the S protein!
 
Breast Tissues Are Far More Rich In ACE2 Receptors Than Lungs!
 
It should be noted that studies have already confirmed that breast tissues are rich in ACE2 receptors ie the receptors that the SARS-CoV-2 virus have an affinity to bind with and to get access into host cells. In fact, studies have confirmed that the levels of ACE2 receptors in breast tissues are much higher than that of lungs tissues!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025721/
 
SARS-CoV-2 viral persistence has also been discovered in breast tissues!
https://www.thailandmedical.news/news/yet-another-study-confirms-viral-persistence-in-so-called-covid-19-recovered-patients-this-time-in-breast-and-appendix-tissues-of-two-patients-with-lo
 
Many other studies have also indicated that the inflammatory state brought about by SARS-CoV-2 infections are conducive for cancer development and progression.
https://www.frontiersin.org/articles/10.3389/fmolb.2021.813175/full
 
https://www.actascientific.com/ASCB/pdf/ASCB-04-0322.pdf
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-021-01363-1
https://www.researchsquare.com/article/rs-2529295/v1
 
In brief, we can expect an exponential rise in breast cancer incidences and also deaths from breast cancer in coming months and years.

For the latest COVID-19 News, keep on logging to Thailand Medical News.

Read Also:
https://www.spandidos-publications.com/10.3892/ijo.2022.5332

https://pubs.rsna.org/doi/10.1148/radiol.222040

https://www.hindawi.com/journals/cris/2020/8876475/
 
We are in the midst of setting up 27 new sites focussing on various cancers as we can foresee that cancer is going to be a major issue thereafter, including sites like https://breastcancer.news/  etc. Individuals and companies wanting to help, contribute or collaborate are welcome to contact us via email at : tmnacct@gmail.com