BREAKING!! Male Infertility: Research Shows That SARS-CoV-2 Coronavirus May Indirectly Cause Testicular Damage In Male COVID-19 Patients And Also Orchitis
Source: Male Infertility And Orchitis Jun 04, 2020 4 years, 5 months, 2 weeks, 5 days, 22 hours, 53 minutes ago
Male Infertility: A Peer-reviewed study published in the journal European Urology Focus indicates that the SARS-CoV02 coronavirus is able to cause damage to the testicles without even actually entering the testicular cells.
https://www.sciencedirect.com/science/article/pii/S2405456920301449?dgcid=rss_sd_all
A pathological analysis of patient samples from a hospital in Wuhan showed that the SARS-CoV-2 coronavirus caused ‘ballooning changes’ and damage to cells that produce sperm.
The researchers from the joint study involving both American and Chinese researchers believe this could have been the result of the novel coronavirus binding to an enzyme on the cell surface and could causing damage to the testicles without actually infecting them.
It was discovered that the coronavirus could enlarge and attack the cells that produce sperm, possibly by binding to an enzyme on the cell surface.
However, the research team said there were almost no viral genes found in the semen and testicular tissue of patient samples, suggesting it was not a sexually transmitted infection.
The researchers warned, “Sperm donation or an impregnation plan could be considered during convalescence for Covid-19 patients. Also all recovered patients should be monitored for possible infertility issues in the future.”
There has been debate over the potential impact of the virus on male fertility since it was first reported in the central Chinese city of Wuhan late last year.
Certain research has detected male hormone abnormalities, but in other studies no trace of the virus has been found in patients’ sperm samples.
Orchitis which is an inflammation of one or both testicles caused by pathogens such as bacteria and viruses have been reported in both SARS and also COVID-19 cases.
https://www.rbmojournal.com/article/S1472-6483(20)30188-7/fulltext
In the United States a case was reported a 42-year-old man who sought emergency treatment for “constant stabbing pain that originated from his groin” and later tested positive for Covid-19. The case was highlighted in the medical journal:
The American Journal of Emergency Medicine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138186/
There were also many previous preprint studies that were not peer reviewed from China that also indicated about one in five men reported “scrotal discomfort” after contracting the SARS_CoV-2 coronavirus.
In the recent research, samples from 11 patients who died from Covid-19 in Wuhan were analyzed by a team led by Dr Ming Zhou, a Professor with the Tufts Medical Centre in Boston, and Dr Nie Xiu, from the Huazhong University of Science and Technology in Wuhan.
The researchers tested for viral genes in tissues involved in
sperm and testosterone production, and some samples were also assessed for damage caused by the virus.
However only one sample showed a trace of the virus, from a patient with a high viral load. That result could have been because the virus was “present in blood rather than in testicular tissue”, the researcher noted.
Significantly, more than 80 per cent of the samples showed major damage to the seminiferous tubules ie the part of the testicles where sperm is made.
It was observed that these cells making up these tiny tubes underwent “ballooning changes”, becoming much bigger than healthy cells. Some were also damaged to an extent that sperm production could have been affected, the research team warned.
The researchers said it was unclear how the virus did this without entering the testicular cells but noted that the testicles contain an enzyme known as ACE2, which the SARS-CoV-2 coronavirus can bind to using a spike protein.
Dr Ming Zhou told Thailand Medical News, “We speculate that viral membrane proteins, such as the spike protein, may play a role in the injury.”
Dr Zhang Shuye, a principal investigator with the Shanghai Public Health Clinical Centre at Fudan University, who was not involved in the study, said there was growing support but “no direct scientific proof” for the theory that the SARS-CoV-2 coronavirus could cause damage without actually entering a cell.
He cited the ACE2 enzyme, which has important roles such as regulating blood pressure as an example of how this could happen.
Dr Zhang said, “A large number of viral strains can bind to ACE2 and can affect its normal function and this could lead to damage of certain cell types that depend on the enzyme.”
However it should be ruled out that damage found in the study samples could also have been caused by immune system malfunction, the researchers warned as certain critically ill Covid-19 patients suffer from multiple organ failure, and previous research has suggested that this could be caused by a destructive immune system overreaction.
Dr Zhou’s team concluded that based on the research findings, “studies should be undertaken to find ways to mitigate the risk of testicular injury during the Covid-19 disease course”.
Thailand Medical News had published as early as the 16
th Of February warning that the SARS-CoV-2 coronavirus could affect the male reproductive organs and also fertility issues based on various studies but facebook fact checkers and a certain so called Italian ‘medical expert’ journalists who in reality were scammers who tried unsucessfully to the label the article as fake news.
https://www.thailandmedical.news/news/breaking-news!-latest-research-published-by-chinese-scientists-say-coronavirus-might-render-certain-male-patients-infertile
Maybe that it why many Italians contracted the virus and died as a result of the misinformation perpetrated by many of their unqualified journalist and 'garbage' online sites and publications and by unqualified fact checkers employed by facebook.
Please help to disseminate and share this article to as many people as possible.
For more on
orchitis and
male infertility, keep on logging to Thailand Medical News
