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BREAKING NEWS
Source: SARS-CoV-2 Variants  Jul 31, 2021  3 years, 4 months, 3 weeks, 1 day, 22 hours, 41 minutes ago

BREAKING! Scientific Advisors To The British Government Warns That A Super SARS-CoV-2 Variant That Could Kill One In Three People Could Emerge!

BREAKING! Scientific Advisors To The British Government Warns That A Super SARS-CoV-2 Variant That Could Kill One In Three People Could Emerge!
Source: SARS-CoV-2 Variants  Jul 31, 2021  3 years, 4 months, 3 weeks, 1 day, 22 hours, 41 minutes ago
An alarming warning has been issued by the Scientific Advisory Group for Emergencies (SAGE) ie a British Government body that advises the central British government in emergencies and chaired by the United Kingdom's Chief Scientific Adviser, Sir Patrick Vallance, that future strains of the SARS-CoV-2 coronavirus could be as deadly as MERS, which kills 35% of those it infects.

The warnings were initially made to the British government and not publicly and were uncovered in accessed British Government documents. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1007566/S1335_Long_term_evolution_of_SARS-CoV-2.pdf
 
The scientist warns that a new SARS-CoV-2 variant that kills a third of the people it infects is a 'realistic possibility' according to the government's science advisors.
 
Rapid and potent mutations are most likely to occur when the virus is widely spread as it is currently in the UK and could change in such a way that allows it to evade current vaccines.
 
The sudden emergence of such strains could lead to a return to tighter restrictions and lockdowns, while delivering another huge economic blow to the country.
 
The experts suggested the new strain could be resistant to vaccines if formed from the jab-resistant 'South Africa' Beta variant along with the more transmissible Alpha or Delta variants.
 
The report now being made public via various media has alarmed scientists and researchers all over the world with many echoing that such a possibility is extremely high.
 
Vice-chair of the All-Party Parliamentary Group on Coronavirus, Dr Philippa Whitford urged those in charge to pay attention to the alarming report.
 
She told media, "This report, which should have sent shock waves through the UK Government, was instead quietly snuck out among a glut of reports during parliamentary recess. Recommendations and comments made by SAGE bring home the simple reality ie that we have not yet 'defeated' this virus."
 
In another report, scientists warned that the protection that vaccines give against coronavirus infection, and potentially severe disease, is highly likely to wane over time.
 
The scientist warns of the high possibility of a emerging variant that causes severe disease in a greater proportion of the population than has occurred to date. For example, with similar morbidity/mortality to other zoonotic coronaviruses such as SARS-CoV (~10% case fatality) or MERS-CoV (~35% case fatality).
 
The scientist said that this could be caused by:
 
-Firstly via point mutations or recombination with other host or viral genes. This might occur through a change in SARS-CoV-2 internal genes such as the polymerase proteins or accessory proteins. These genes determine the outcome of infection by affecting the way the virus is sensed by the cell, the speed at which the virus replicates and the anti-viral response of the cell to infection.
 
There is precedent for Coron aviruses (CoVs) to acquire additional genes or sequences from the host, from themselves or from other viruses.
 
-Secondly by recombination between two VOC or VUIs. One with high drift (change in the spike glycoprotein) from the current spike glycoprotein gene used in the vaccine and the other with a more efficient replication and transmission determined by internal genes, for example, a recombination between beta and alpha or delta variants respectively. Alternatively, recombination may occur between two different variants with two different strategies for overcoming innate immunity, combining to give an additive or synergistic change of phenotype resulting in higher replication of the virus – and potentially increased morbidity and mortality.
 
They stressed that the likelihood of genotypic change in internal genes is very likely whilst the circulation of SARSCoV-2 is high.
 
Also the likelihood of increased severity phenotype is also very high.
 
However the scientists said that unless there is significant drift in the spike glycoprotein gene sequence, then the current spike glycoprotein-based vaccines are highly likely to continue to provide protection against serious disease. However, an increase in morbidity and mortality would be expected even in the face of vaccination since vaccines do not provide absolute sterilizing immunity i.e. they do not fully prevent infection in most individuals.
 
But at the same time, other emerging reports are indicating that the protection that vaccines give against coronavirus infection, and potentially severe disease, is highly likely to wane over time.
 
Hence vaccine campaigns will continue for years to come.
 
One such report was titled "How long will vaccines continue to protect against COVID?", was written by prominent virologists and epidemiologists from Imperial College London, University of Birmingham and Public Health England.
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1007573/S1332_How_long_will_vaccines_continue_to_protect_against_COVID-19.pdf
 
The United Kingdom has approved and is using three shots -Oxford-AstraZeneca, Pfizer-BioNTech and Moderna - in a mass vaccination programme that started in December 2020.
 
To date real world data show that these vaccines protect with 95% or greater effectiveness against the Alpha variant that dominated in Britain in early 2021, the scientists said, although the ability of the shots to protect against infection and onward transmission was lower.
 
The scientists warned that it might be expected that vaccine effectiveness would remain high for severe disease but effectiveness against mild disease and infection could fall off over time.
 
Interestingly anecdotal reports from Britain and Israel, which rolled out a comprehensive early campaign, supported that concept, they said.
Certain countries like Israel will begin offering a third shot of the Pfizer-BioNTech COVID-19 vaccine to people aged over 60, a world first in efforts to slow the spread of the highly contagious Delta variant.
 
However since the emergence of the Delta variant, the Israeli health ministry has twice reported a drop in the vaccine's efficacy against infection and a slight decrease in its protection against severe disease.
 
Emergence of second and third generation variants of the Delta variant and also the emergence of the new fast spreading Lambda variant is likely to change the whole kinetics of the COVID-19 pandemic and there will be fun times ahead.
 
Off course hopefully by the time the ‘Omega variant’ finally arrives sometime by the mid of 2023, then only maybe the world might finally realize its stupidity of relying too much on antibody based therapeutics instead of identifying or developing a combination antiviral drugs. Off course lets hope that all the stupid and ignorant ‘dinosaurs’ are eradicated from the face of the earth by then!
 
For more on the COVID-19 Pandemic Kinetics, keep on logging to Thailand Medical News.
 
 
 
 

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