BREAKING! Toxoplasma Gondii: University of Virginia Study Says That About Two Billion People Have A Brain Parasite Spread By Cats And Contaminated Meat
Source: Toxoplasma Gondii Aug 01, 2020 4 years, 3 months, 3 weeks, 15 hours, 47 minutes ago
Toxoplasma Gondii: A new discovery from the University of Virginia School of Medicine (UVA) indicates that more than two billion people are infected with a brain parasite spread by cats and contaminated meat, but most will never show symptoms and the research findings could have important implications for brain infections, neurodegenerative diseases and autoimmune disorders.
The study team from UVA found that the parasite,
Toxoplasma gondii, is kept in check by brain defenders called microglia. These microglia release a unique immune molecule, IL-1a, that recruits immune cells from the blood to control the parasite in the brain, the scientists discovered. This process works so well that very few people develop symptomatic toxoplasmosis, the disease the parasite causes.
The research findings were published in the journal: Nature Communications.
https://www.nature.com/articles/s41467-020-17491-z
Proper understanding the role of microglia is essential because they are normally the only immune cells inside the brain. The new finding reveals how they recruit help when needed, and that discovery could apply to any brain condition with an immunological component including brain injury, neurodegenerative disease, stroke, multiple sclerosis and more.
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Co-researcher Dr Tajie Harris, PhD, of UVA’s Department of Neuroscience and the interim director of the Center for Brain Immunology and Glia (BIG) told Thailand Medical News, “Microglia must die to save the brain from this infection. Otherwise the IL-1a remains stuck inside the microglia and wouldn’t alert the immune system that something is wrong.”
University of Virginia’s Department of Neuroscience and BIG center have in recent years completely rewritten our understanding of the brain’s relationship with the body’s immune system. For decades, textbooks taught that the brain was disconnected from the immune system. UVA research, however, showed that was not the case, to the shock of the scientific community. Many researchers are now exploring the implications of that major discovery.
A key area of focus is microglia and their role in defending the brain. This has been a difficult question to answer because microglias are closely related to other immune cells elsewhere in the body. Until recently, laboratory tools made to target microglia have also targeted these other cells, making it hard to distinguish between the two.
Researcher Samantha J. Batista, a graduate student in Harris’ lab-UVA, used an elegant approach that leveraged the long-lived nature of microglia to understand their role in brain infection. She and her colleagues found that infection caused microglia to die in an inflammatory fashion a way that the closely related immune cells do not.
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The researchers observed that the microglia burst in order to recruit immune cells called macrophages to control the Toxoplasma gondii infection. This finding helps explain why most people have no trouble controlling the parasite, while some especially people who are immunocompromised can become very sick.
Batista added, “Understanding pathways like this could be beneficial for other diseases involving neuroinflammation. We can ask whether promoting this pathway is helpful in situations where you need more of an immune presence in the brain, such as infections or cancers, and also whether inhibiting this molecule could be helpful in diseases driven by too much neuroinflammation, like multiple sclerosis. Targeting one specific pathway like this one could have less off-target effects than targeting inflammation more broadly.”
Both Dr Harris and Batista and their collaborators are interested in the future in understanding how microglia detect the parasites in the brain. Microglia could recognize the parasite’s presence directly, or they could recognize damage to brain tissue, a phenomenon that occurs in many diseases.
Dr Harris, who is part of UVA’s Carter Immunology Center further added, “The immune system must enter the brain to fight dangerous infections. We now understand how microglia sounds the alarm to protect the brain. We suspect that similar signals are missed or misinterpreted in Alzheimer’s disease, opening up an exciting new research avenue in the lab.”
Thailand Medical News would like to add that individuals who are immune-compromised due to HIV or even infected with COVID-19, will most probably develop symptomatic toxoplasmosis should they be carrying the parasite in their bodies.
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