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Nikhil Prasad  Fact checked by:Thailand Medical News Team Mar 18, 2024  8 months, 3 days, 6 hours, 52 minutes ago

COVID-19 Can Enhance The Invasiveness And Progression Of Oral Squamous Cell Cancer

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COVID-19 Can Enhance The Invasiveness And Progression Of Oral Squamous Cell Cancer
Nikhil Prasad  Fact checked by:Thailand Medical News Team Mar 18, 2024  8 months, 3 days, 6 hours, 52 minutes ago
COVID-19 News: The COVID-19 pandemic has brought about unprecedented challenges in healthcare, particularly for individuals with pre-existing medical conditions such as cancer. Among the various types of cancer, oral squamous cell carcinoma (OSCC) has garnered attention due to potential associations with COVID-19 exposure. Recent research from Sichuan University in China has shed light on a concerning finding - that COVID-19 may enhance the invasiveness and progression of OSCC. This retrospective cohort study covered in this COVID-19 News report aimed to analyze the clinical and pathological characteristics of OSCC patients with and without a history of COVID-19 exposure, providing valuable insights into post-COVID-19 syndromes and their impact on cancer progression.


COVID-19 Can Enhance The Invasiveness And Progression
Of Oral Squamous Cell Cancer


Thailand Medical News had covered a previous study by Iranian researchers that also showed SARS-CoV-2 infections causes progression of oral cancer progressions.
 
https://www.thailandmedical.news/news/breaking-news-researchers-find-that-sars-cov-2-contributes-to-oral-cancer-progression,-treatment-resistance-and-tumor-recurrence
 
Thailand Medical News also had previous covered studies that showed that SARS-CoV-2 infections can lead to the downregulation of cancer protective and tumor suppressor genes such as p53 and also cause the progression of other cancers!
https://www.thailandmedical.news/news/covid-19-research-bioinformatics-study-reveals-p53-signaling,-genes-nfkbia,-c3,-ccl20-are-among-cellular-pathways-and-genes-affected-by-coronavirus
 
https://www.thailandmedical.news/news/great-news-study-shows-that-sars-cov-2-protein-nsp13-is-able-to-cause-dna-damage-and-dysregulate-tumor-suppressor-gene-p53,-increasing-cancer-risk
 
https://www.thailandmedical.news/news/spanish-study-discovers-that-sars-cov-2-infections-leads-to-downregulation-of-p53-a-critical-cancer-protective-gene
 
ervix-cancers">https://www.thailandmedical.news/news/covid-19-news-scientists-warn-that-sars-cov-2-infections-can-lead-to-rapid-progression-of-cervical-intraepithelial-neoplasia-to-cervix-cancers
 
https://www.thailandmedical.news/news/breaking-news-study-alarmingly-finds-that-sars-cov-2-s-and-n-proteins-drive-invasion-abilities-of-colon-cancer-cells,-resulting-in-rapid-metastasis
 
https://www.thailandmedical.news/news/breaking-sars-cov-2-causes-aggressive-breast-cancer-progression-and-manipulates-tissue-stem-cells-in-the-tumor-microenvironment
 
https://www.thailandmedical.news/news/sars-cov-2-and-cancer-increased-neuropilin-1-expression-as-a-result-of-covid-19-can-lead-to-progression-of-primary-brain-tumors-besides-neurological-i
 
https://www.thailandmedical.news/news/breaking-covid-19-news-sars-cov-2-infections-lead-to-increased-risk-of-breast-cancer,-recurrence-of-breast-cancer-and-also-breast-cancer-metastasis
 
https://www.thailandmedical.news/news/sars-cov-2-rna-replication-is-enhanced-by-p53-independent-g1-cell-cycle-arrest-dependent-of-the-cdc25a-cdk2-cyclin-e-pathway
 
COVID-19 Infections can also cause the upregulation of certain oncogenic genes.
https://www.thailandmedical.news/news/breaking-study-finds-that-cancer-causing-genes-are-upregulated-in-sars-cov-2-infected-individuals
 
https://www.thailandmedical.news/news/breaking-scientists-warns-that-sars-cov-2-also-interacts-with-igf2bp1-an-oncofetal-rna-binding-protein-that-typically-fuels-tumor-virus-propagation
 
https://www.thailandmedical.news/news/cd147-and-cyclophilin-a-cypa-play-key-roles-in-covid-19-severity,-cancer-progression-and-chemotherapy-resistance-in-cancer-patients-with-covid-19
 
https://www.thailandmedical.news/news/breaking-sars-cov-2-activates-epidermal-growth-factor-receptor-mediated-signaling,-inducing-survivin-expression-which-assists-in-cancer-progression
 
It should be noted that even the COVID-19 mRNA vaccines can also enhance the progression of certain cancers and also cause various cancers itself!
https://www.thailandmedical.news/news/covid-19-news-scientists-warn-that-existing-mrna-covid-19-prophylactics-create-environment-for-neoplastic-transformation-leading-to-various-cancers
 
https://www.thailandmedical.news/news/texas-md-anderson-cancer-center-warns-that-covid-19-mrna-vaccines-elevate-pd-l1-levels-disrupting-lung-cancer-treatments-progressing-other-cancers
 
https://www.thailandmedical.news/news/breaking-covid-19-news-doctors-in-thailand-warn-that-covid-19-vaccines-could-possibly-lead-to-tumor-expansion-in-certain-cancers
 
https://www.thailandmedical.news/news/various-peer-reviewed-published-studies-and-case-reports-show-that-mrna-covid-19-vaccines-can-cause-lymphoma
 
https://www.thailandmedical.news/news/doctors-warn-covid-19-mrna-jabs-can-cause-primary-cutaneous-cd4-small-medium-t-cell-lymphoproliferative-disorders-and-cutaneous-lymphomas
 
Understanding the Current Study Design
The study employed a retrospective cohort design, focusing on OSCC patients treated surgically between 2019 and 2023 at the Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University. Medical records were reviewed, and relevant data were extracted using ICD-10 SE diagnosis and intervention codes. The inclusion criteria comprised OSCC patients who underwent radical surgery and consented to participate in the study.
 
Key Findings from Clinical and Pathological Analyses
A total of 200 OSCC patients were included in the study, with 80 patients in the COVID-19 exposure group (Case group) and 94 patients in the non-exposure group (Control group).
 
Notably, patients in the Case group exhibited a higher severity of cervical lymph node metastasis compared to the Control group, indicating a potential association between COVID-19 exposure and OSCC aggressiveness.
 
Furthermore, the study analyzed pathological characteristics, focusing on the expression levels of Ki67 and CyclinD1, both markers associated with cell proliferation and cancer aggressiveness.
 
The results revealed significantly higher expression of Ki67 (71.3%) and CyclinD1 (80%) in OSCC patients with a history of COVID-19 exposure compared to those without exposure. Statistical analyses confirmed that COVID-19 exposure was an independent influencing factor for increased Ki67 and CyclinD1 expression, further supporting the hypothesis that COVID-19 may contribute to the invasiveness and progression of OSCC.
 
Implications and Future Directions
These findings have significant implications for clinical practice and cancer management strategies. Healthcare providers should consider the potential impact of COVID-19 exposure on OSCC progression when assessing and treating patients. Additionally, further research is warranted to elucidate the underlying mechanisms linking COVID-19 with enhanced cancer aggressiveness, paving the way for targeted interventions and personalized treatment approaches.
 
Discussion on Post-COVID-19 Syndromes and Cancer
The study's findings align with emerging research highlighting the diverse post-COVID-19 syndromes and their potential long-term effects on health. While much attention has been focused on respiratory and systemic complications of COVID-19, the study underscores the need to explore its implications for cancer biology and progression. Understanding the interplay between viral infections, immune responses, and cancer pathways is crucial for developing comprehensive strategies to mitigate the impact of COVID-19 on cancer patients.
 
Moreover, the study emphasizes the importance of multidisciplinary collaboration between oncologists, infectious disease specialists, and immunologists to address the complex interactions between COVID-19 and cancer. Future studies should delve deeper into molecular mechanisms, immune modulation, and therapeutic interventions aimed at mitigating the adverse effects of COVID-19 on cancer outcomes.
 
Conclusion
In conclusion, the study conducted at Sichuan University-China provides compelling evidence of a potential link between COVID-19 exposure and increased invasiveness and progression of oral squamous cell carcinoma. The higher expression of Ki67 and CyclinD1 in OSCC patients with COVID-19 exposure highlights the need for continued research and vigilance in managing cancer patients during and post-pandemic. By elucidating these associations, healthcare providers can optimize patient care and improve outcomes for individuals battling both COVID-19 and cancer.
 
The study findings were published the peer reviewed journal: Oral Oncology.
https://www.sciencedirect.com/science/article/abs/pii/S1368837524000587
 
For the latest COVID-19 News, keep on logging to Thailand Medical News.
 
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https://www.thailandmedical.news/news/breaking-discoveries-cell-surface-protein-hspa5-bip-grp78-unveiled-as-key-player-in-cancers-and-is-also-a-receptor-for-sars-cov-2
 
https://www.thailandmedical.news/news/understanding-the-link-between-covid-19-and-cancer-the-role-of-the-slc6a20-gene
 
https://www.thailandmedical.news/news/covid-19-news-while-lymphopenia-is-common-in-sars-cov-2-infections,-some-may-suffer-from-b-cell-lymphocytosis,-that-leads-to-lymphocytic-leukemia
 
https://www.thailandmedical.news/news/breaking-study-finds-that-upregulated-interleukin-6-drives-development-of-rare-liver-cancers-covid-19-infections-causes-elevated-il-6-levels-in-many
 
https://www.thailandmedical.news/news/breaking-study-discovers-sars-cov-2-could-be-carcinogenic-as-it-causes-mutagenesis,-telomere-dysregulation-and-impairs-dna-mismatch-repair
 
https://www.thailandmedical.news/news/post-covid-19-individuals-advised-to-take-probiotics-as-study-shows-sars-cov-2-induced-gut-microbiome-dysbiosis-increases-risk-for-colorectal-cancer
 
https://www.thailandmedical.news/news/breaking-new-international-study-warns-that-sars-cov-2-infections-will-lead-to-cancers-especially-colorectal-cancers-due-to-disruption-in-autophagy
 
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https://www.thailandmedical.news/news/covid-19-and-cancer-study-shows-that-sars-cov-2-and-usage-of-anti-covid-19-drugs-can-reactivate-oncogenic-viruses-and-increase-risk-of-cancer

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