COVID-19 Disinfectants: Miramistin A Cold War Antiseptic Has Potential In Fight Against Drug-Resistant Germs And Viruses, Researchers Urge Study For SARS-CoV-2
Source: COVID-19 Disinfectants Jul 04, 2020 4 years, 4 months, 2 weeks, 4 days, 20 hours, 42 minutes ago
COVID-19 Disinfectants: University of Manchester scientists say that a little-known non-toxic antiseptic developed in the Soviet Union during the Cold War has enormous potential to beat common infections and that even detailed studies should be conducted with regards to its use in the current COVID-19 scenario. Their report was published in the journal: FEMS Microbiology Reviews.
https://academic.oup.com/femsre/article-abstract/doi/10.1093/femsre/fuaa012/5835225?redirectedFrom=fulltext
The disinfectant
Miramistin was developed for the Soviet Space Program and little known in the West, can inhibit or kill influenza A, human papilloma viruses that cause warts, coronaviruses, adenoviruses, and human immunodeficiency virus (HIV).
The chemical potion is much less toxic to human cells than conventional antiseptics such as cyclohexamide and cetylpyridinium chloride, and is also biodegradable.
The antispetic can be used against Candida and Aspergillus species, and also kills bacteria, including Stарhуlососсus, Proteus and Klebsiella as well as the bugs that cause syphilis and gonorrhea.
The compound Miramistin is still used in some of the former countries of the Soviet Bloc in hospitals and surgeries, mainly to treat to treat wounds and ulcers. However, it is barely known elsewhere and there is almost no mention of it in the English literature.
Professor Dr David Denning from the University of Manchester, who was on the research team told Thailand Medical News, "Conventional antiseptics contaminate the environment because they are toxic to microbiota, fish, algae, and plants. These are widely available but problematic, whereas Miramistin has no genotoxic effects after it has been broken down."
"Miramistin has been overlooked in the West and may have practical and environmental advantages," said Dr Ali Osmanov lead author of the study.
Also widely used antiseptics with chlorinated aromatic structures including triclosan and triclocarban barely degrade and so persist in the environment for long significant periods, even decades. In contrast, Miramistin is 88–93% biodegradable
Dr Ali Osmanov, was awarded a scholarship to study fungal disease at Manchester, examined Miramistin in the lab for his dissertation project.
He discovered when he was in his native country, Ukraine the extensive clinical use of Miramistin, causing him to consider if it might be useful elsewhere.
Dr Osmanov added, "Miramistin has been overlooked in the West and may have practical and environmental advantages. Today, antiseptics act as a 'last frontier' against antibiotic-resistant bacteria and viruses, and also have important role in infection control. Unfortunately, currently used antiseptics have some flaws.”
He further added, ”For example, bleach can exacerbate asthma, and many of the older antiseptics are not active against coronaviruses. We hope our paper will stimulate modern studies to evalua
te Miramistin's potential. Considering emerging antimicrobial resistance, the significant potential of miramistin justifies its re-evaluation for use in other geographical areas and conditions."
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