COVID-19 News: SARS-CoV-2 Coronavirus ‘Attacks’ Mitochondria, The ‘Power House’ Of Cells In Human Host. Constant Fatigue Could Result From This
Source: COVID-19 News Jan 20, 2021 3 years, 11 months, 3 days, 8 hours, 53 minutes ago
COVID-19 News: Scientist from the University of Southern California have discovered that the SARS-CoV-2 coronavirus typically ‘attacks’ the mitochondria in the cells of the human host. The resulting disruptions in the ‘power house’ of the cells could be one reason many COVID-19 patients and also post COVID patients often suffer from chronic fatigue.
In their study abstract, the study team said that the SARS-CoV-2 coronavirus induces a muted innate immune response compared to other respiratory viruses.
Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling.
Therefore, the study team hypothesizes that SARS-CoV-2 would distinctly regulate the mitochondrial transcriptome. The study team analyzed multiple publicly available RNASeq data derived from primary cells, cell lines, and clinical samples (i.e., BALF and lung).
The study team report ed that SARS-CoV-2 did not dramatically regulate (1) mtDNA-encoded gene expression or (2) MAVS expression, and (3) SARS-CoV-2 downregulated nuclear-encoded mitochondrial (NEM) genes related to cellular respiration and Complex I.
The study findings were published in the peer reviewed journal: Scientific Reports By Nature.
https://www.nature.com/articles/s41598-020-79552-z
The scientists discovered an important line of attack used by the novel coronavirus: it targets the mitochondria, which not only generate the energy that powers a cell's biochemical reactions but also play important roles in immune function.
Dr Pinchas Cohen from the University of Southern California, whose team published its findings this month told Thailand Medical News, "We knew that when the virus attacks cells, bad things happen but we didn't know why. Now we can say, when the virus attacks cells, it damages the mitochondria."
The study team found that the virus caused "dramatic changes and impairment" in the genes that regulate mitochondrial function.
The implication is that energy production in the cells and innate immunity are then impaired.
Another implication is that having healthy mitochondria would help people combat the virus if they do become infected, he said.
Dr Cohen said, "We know that a healthy diet and healthy lifestyle promote mitochondrial health," whereas mitochondrial function deteriorates with age and with many chronic conditions including diabetes and heart disease.”
Dr Cohen added that perhaps in the future, researchers may develop COVID-19 interventions to help improve mitochondrial health.
A previous study in October 2020 led by the University of California-San Francisco also found that the Orf9b protein of the SARS-CoV-2 coronavirus also bound to the human host mitochondria protein called Tom70, in the process disrupting the mitochondria functions.
https://www.thailandmedical.news/news/b
reaking-covid-19-research-coronavirus-study-reveals-that-sars-cov-2-orf9b-protein-binds-to-human-host-mitochondria-protein-tom70
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