COVID-19 Symptoms And Clinical Care: SARS-CoV-2 Infection May Initially Present As Only Acute Pancreatitis Before Disease Progression
Source: COVID-19 Symptoms And Clinical Care Aug 29, 2020 4 years, 3 months, 3 weeks, 6 days, 6 hours, 19 minutes ago
COVID-19 Symptoms And Clinical Care: A new study led by researchers from University of Arkansas for Medical Sciences in Little Rock, and also from other medical schools and institutions have discovered that in certain infected COVID-19 patients, typical symptoms of the disease might not manifest itself but the individuals will instead normally develop acute pancreatitis first prior to disease progression.
The study findings were published in the journal: Gastroenterology.
https://www.gastrojournal.org/article/S0016-5085(20)35115-5/pdf or
https://www.gastrojournal.org/article/S0016-5085(20)35115-5/fulltext
Though it was already found through various clinical observations and studies in the last few months that certain COVID-19 patients would ultimately develop pancreatitis as the disease progresses, this is the first study to show the anomaly where pancreatitis first materializes before disease progression.
Lead researcher Dr Sumant Inamdar, M.B.B.S., from the University of Arkansas for Medical Sciences in Little Rock, and colleagues assessed the point prevalence, risk factors, and outcomes of hospitalized patients with COVID-19 presenting with acute pancreatitis in a large New York health system (March 1 through June 1, 2020). Outcomes were compared for those with pancreatitis and COVID-19 versus those with pancreatitis but without COVID-19.
The study team found that during the study period, 189 patients met the criteria for a diagnosis of pancreatitis (point prevalence, 0.39 percent), and 32 of the 189 (17 percent) were COVID-19-positive, yielding a point prevalence of 0.27 percent of pancreatitis among patients hospitalized with COVID-19. There was a higher proportion of Black and Hispanic patients with pancreatitis in the COVID-19-positive group versus the COVID-19-negative group, which remained significant in an adjusted analysis (odds ratios, 4.48 and 5.07, respectively).
Patients with pancreatitis and COVID-19 were more likely to require mechanical ventilation and have longer hospital stays versus patients with pancreatitis but not COVID-19 (odds ratios, 5.65 and 3.22, respectively).
Dr Inamdar told Thailand Medical News, "These findings support the notion that pancreatitis should be included in the list of gastrointestinal manifestations of COVID-19."
Physicians are also advised to screen patients exhibiting pancreatitis or other gastrointestinal problems for COVID-19.
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