COVID-19 Vaccine Causes Acquired Hemophilia A by Generating Autoantibodies That Inhibit Coagulation Factors
Nikhil Prasad Fact checked by:Thailand Medical News Team Mar 10, 2025 1 month, 3 days, 17 hours, 9 minutes ago
Medical News: Acquired Hemophilia A (AHA) that was once a rare autoimmune disorder, is characterized by the development of autoantibodies that inhibit coagulation factor VIII (FVIII), which is essential for blood clotting. Unlike congenital hemophilia, which is inherited, AHA occurs spontaneously, often in individuals with no prior history of bleeding disorders. The condition is more common in the elderly and postpartum women but can arise in individuals of any age. Patients with AHA typically experience severe bleeding episodes, including spontaneous bruising, deep tissue hematomas, and mucosal bleeding. Without timely diagnosis and treatment, AHA can lead to life-threatening hemorrhages.
COVID-19 Vaccines Causes Acquired Hemophilia A by Generating Autoantibodies That Inhibit Coagulation Factors
The exact cause of AHA remains unclear, but it has been linked to various conditions, including autoimmune diseases, malignancies, infections, and certain medications. This
Medical News report explores the association between COVID-19 vaccinations and the onset of AHA, a topic that has gained increasing attention in recent years.
The Immune Response and Vaccine-Induced Autoimmunity
Vaccines, including those developed for COVID-19, supposedly work by stimulating the immune system to produce protective antibodies against the targeted pathogen. However, in certain instances, this immune activation can trigger autoimmune reactions, leading to the production of antibodies that mistakenly attack the body's own proteins. Previous vaccines, such as those for influenza and hepatitis B, have been linked to autoimmune disorders, raising concerns about similar effects from COVID-19 immunization.
Among the COVID-19 vaccines, mRNA-based vaccines, such as Pfizer-BioNTech's BNT162b2 and Moderna's mRNA-1273, have been associated with cases of AHA. Reports have emerged of individuals developing severe bleeding symptoms after receiving COVID-19 vaccines, with laboratory tests confirming the presence of FVIII inhibitors. Some cases have shown a direct temporal relationship between vaccination and the onset of AHA, suggesting a causal link. In some cases, the onset of AHA was slow and was only discovered months or even years later.
Clinical Cases and Observations
Several reports have documented cases of AHA occurring after COVID-19 vaccination. The affected individuals, most of whom had no prior bleeding disorders, exhibited symptoms such as unexplained bruising, gastrointestinal bleeding, and significant hematoma formation. Blood tests revealed prolonged activated partial thromboplastin time (aPTT) and the presence of FVIII inhibitors, confirming the diagnosis of AHA.
While most patients responded well to standard treatments, including immunosuppressive therapy with corticosteroids and cyclophosphamide, a few cases resulted in severe complications, including fatal bleeding or infections. These cases highlight the importance of early recognition and intervention to improve patient outcomes.
>Evaluating the Risks and Benefits
Some experts suggest that the association between COVID-19 vaccination and AHA could be coincidental rather than causative. Given that AHA can occur spontaneously or in association with other conditions, it is challenging to establish a direct link between vaccination and the onset of the disease. However, continuous monitoring and research are necessary to determine whether specific populations may be more susceptible to vaccine-induced autoimmune responses.
The Need for Further Research
To better understand the potential relationship between COVID-19 vaccines and AHA, further studies and detailed registries are required. Healthcare professionals should remain vigilant for unusual bleeding symptoms following vaccination and conduct appropriate laboratory evaluations when necessary. Additionally, prospective studies could help identify potential risk factors, such as genetic predispositions or preexisting immune system abnormalities, that might contribute to vaccine-induced autoimmunity.
The scientific community must also explore alternative vaccine formulations and dosing regimens that minimize autoimmune risks while maintaining high levels of protection against COVID-19. As research progresses, public health authorities should communicate findings transparently to ensure informed decision-making among healthcare providers and the general population.
Conclusion
Acquired Hemophilia A is a serious autoimmune disorder that can lead to severe bleeding complications. Continued surveillance, research, and clinical awareness are essential to ensure early detection and management of potential vaccine-related adverse events.
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Please use google scholar as there are over 460 plus studies, case reports and case series showing the onset of acquired haemophilia A after the COVID-19 vaccines.
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