Dietary Fisetin And Fisetin Supplements Emerging As Promising Therapeutic Agents For Antiaging and Longevity
Antiaging Supplements - Fisetin May 17, 2023 1 year, 6 months, 1 week, 15 hours, 59 minutes ago
Antiaging Supplements: In the pursuit of longevity and the reversal of aging, numerous agents have sparked significant interest among the scientific community. One such agent is fisetin, a natural flavonoid that has demonstrated promising benefits in animal studies.
This article delvse into the world of fisetin, to shed light on its potential advantages, how it could be incorporated into your lifestyle, and whether it should be part of your longevity regimen.
Fisetin is a naturally occurring compound, rich in various fruits and vegetables, belonging to the flavonoid family. The flavonoids, known for their numerous health benefits, boast fisetin as one of their more potent members. This compound has shown a multitude of advantageous properties for the human body, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects.
Animal studies have repeatedly demonstrated fisetin's potential to combat cancer, Alzheimer's disease, and the damaging effects of a stroke. Moreover, research has also indicated fisetin's ability to delay the skin aging process caused by harmful UV-A radiation.
While its presence is abundant in a range of fruits and vegetables, such as strawberries, apples, persimmons, onions, grapes, kiwi fruit, and cucumbers, fisetin can also be consumed as a supplement. However, the ideal dosage for human consumption has yet to be determined.
The potential of fisetin as
Antiaging Supplements is rooted in its ability to target senescent cells. Senescent cells, which stop dividing but refuse to die, are thought to be a primary driving force behind aging and age-related diseases. By decreasing the prevalence of these cells in various tissues, fisetin has demonstrated the ability to extend the lifespan of mice and reduce age-related pathologies. However, the real question remains: can fisetin reverse aging in humans? And if so, how?
Fisetin operates as an anti-aging agent by reducing inflammation within the body, which is known to cause chronic illnesses and contribute to aging. Furthermore, it combats oxidative damage, another factor leading to accelerated aging and degenerative diseases. Its effect mimics the outcomes of a calorie-restricted diet, aiding in boosting immune health and potentially increasing lifespan.
Studies on rodents have also suggested that fisetin can increase lifespan by approximately 10% and result in fewer age-related problems.
https://www.sciencedirect.com/science/article/pii/S2352396418303736
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/
https://link.springer.com/article/10.1007/s13659-022-00339-y
https://www.frontiersin.org/articles/10.3389/fphar.2021.612078/full
This lifespan extension is attributed to the activation of
sirtuins, a family of signaling proteins involved in metabolic regulation. As sirtuin functionality declines with age, fisetin steps in to counteract this decline.
Moreover, fisetin acts as a potent senolytic, helping to eradicate senescent cells and extend lifespan. In addition to reducing the number of these "zombie cells," fisetin also restores tissue homeostasis and decreases aging-related pathologies.
Despite the promising animal studies, it is crucial to note that the anti-aging effects of fisetin in humans have yet to be conclusively proven. Clinical trials are currently underway to determine whether the benefits observed in animals can be replicated in humans.
Fisetin has the potential to produce significant health benefits with minimal side effects. However, anyone considering starting a new supplement regimen should always consult with their doctor or pharmacist to ensure safety. The journey to understanding the full potential of fisetin is ongoing, and the prospect of this naturally occurring compound offering a viable path to enhanced longevity is indeed exciting.
Additional references:
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(18)30373-6/fulltext
https://www.worldofmolecules.com/anti-aging-and-senolytics/fisetin-molecule.html
https://www.liebertpub.com/doi/10.1089/ars.2012.4901
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Fisetin-Cognitive-Vitality-For-Researchers.pdf
https://pubs.rsc.org/en/content/articlelanding/2018/FO/C7FO01898C
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Antiaging Supplements, keep on logging to Thailand Medical News.
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