H5N1 Avian Flu News Feb 26, 2023 1 year, 8 months, 3 days, 19 hours, 45 minutes ago
H5N1 Avian Flu News: Below are summaries of latest about the H5N1 Avian Flu Threat.
Genome Sequencing Reveals That H5N1 Virus Found In Cambodia Belongs To Clade 2.3.2.1c.
It has been reported that genome sequencing of the H5N1 Avian Flu virus that killed a Cambodian girl and infected a few others belonged to the 2.3.2.1c. Clade that has been endemic in South-east Asia for the last 10 years without any previous evidence of human-to human transmission.
https://twitter.com/E_A_Karlsson/status/1629711667063033866
https://pubmed.ncbi.nlm.nih.gov/31815962/
The virus is not the same as the virus from the 2.3.4.4b clade that is currently infecting wild birds, poultry and mammals across the globe.
Bird Flu Descends In Jharkhand's Bokaro District In India, Resulting In The Culling Of About 4,000 Chickens And Ducks.
Latest
H5N1 Avian Flu News reports from India indicated that a state in eastern India called Jharkhand has also been hit by the H5N1 Avian Flu virus with lots of farmed chickens and ducks getting sick and dying.
https://zeenews.india.com/india/bird-flu-in-india-culling-of-nearly-4000-chickens-ducks-starts-in-jharkhand-amid-avian-influenza-outbreak-2577161.html
Health authorities yesterday ordered the culling of over 4,000 chickens and ducks to control the situation in the state.
To date, no humans in the state have contracted the disease.
Study Conducted in 2020 Shows That H5N1 Avian Flu Virus Suppresses T Cell Functions.
A study conduced in 2020 by American researchers showed that the H5N1 Avian Flu virus causes the suppression of T Cell functions resulting in a dysfunctional immune system.
https://pubmed.ncbi.nlm.nih.gov/32075925/
According to the study team, avian H5N1 influenza virus infections can result in prolonged and fatal illness across all age groups, which has been attributed to the overt and uncontrolled activation of host immune responses.
The study findings showed that T cell functions important for clearing virally infected cells are impaired by higher negative regulatory signals during modified avian influenza virus infection. In addition, memory T cell numbers were decreased in modified avian influenza virus-infected mice. The study findings provide a possible mechanism for the severe and prolonged disease associated with avian influenza virus infections in humans.
Netherlands Study Published In 2023 Worryingly Finds Zoonotic Mutation of Hi
ghly Pathogenic Avian Influenza H5N1 Virus In the Brain of Multiple Wild Carnivore Species
A study conducted by Dutch researchers on carnivore species infected with highly pathogenic avian influenza (HPAI) virus subtype H5N1 during the 2021–2022 outbreak in the Netherlands including red fox (Vulpes vulpes), polecat (Mustela putorius), otter (Lutra lutra), and badger (Meles meles) found that many were developing neurological symptoms.
The HPAI H5N1 virus was detected by PCR and/or immunohistochemistry in 11 animals and was primarily present in brain tissue, often associated with a (meningo) encephalitis in the cerebrum.
In contrast, the virus was rarely detected in the respiratory tract and intestinal tract and associated lesions were minimal.
Full genome sequencing followed by phylogenetic analysis demonstrated that these carnivore viruses were related to viruses detected in wild birds in the Netherlands. The carnivore viruses themselves were not closely related, and the infected carnivores did not cluster geographically, suggesting that they were infected separately.
The mutation PB2-E627K was identified in most carnivore virus genomes, providing evidence for mammalian adaptation.
This study showed that brain samples should be included in wild life surveillance programs for the reliable detection of the HPAI H5N1 virus in mammals.
The study findings were published in the peer reviewed journal: Pathogens.
https://www.mdpi.com/2076-0817/12/2/168
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