Herbs And Phytochemicals: Oroxylum Indicum Extracts Boosts Brain Health And Are Neuroprotective
Nikhil Prasad Fact checked by:Thailand Medical News Team Jun 17, 2024 6 months, 1 week, 1 day, 5 hours, 41 minutes ago
Herbs And Phytochemicals: Neurodegenerative diseases like Alzheimer's and Parkinson's are significant health challenges worldwide. Researchers have been exploring natural remedies to support brain health and protect against such conditions. One promising solution is an extract from the Oroxylum indicum tree, commonly known as the Indian trumpet tree. This extract, called Sabroxy, has shown potential in enhancing brain function and protecting neurons. This
Herbs And Phytochemicals news report features studies by researchers from Texas A&M University-USA and Sabinsa Corporation, New Jersey-USA on the brain boosting and neuroprotective properties of the phytochemicals found in the Oroxylum Indicum plant.
Oroxylum Indicum Extracts Boosts Brain Health And Are Neuroprotective.
What is Oroxylum Indicum?
Oroxylum indicum is a medicinal plant traditionally used in various Asian cultures. Its bark, roots, and seeds are known for their therapeutic properties. The standardized extract of this plant, Sabroxy, contains three major compounds: oroxylin A, chrysin, and baicalein. These compounds are believed to work together to provide significant neuroprotective benefits.
The Role of BDNF in Brain Health
Brain-derived neurotrophic factor (BDNF) is a protein crucial for brain health. It supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. Low levels of BDNF are linked to several neurological disorders, including Alzheimer's and depression. Enhancing BDNF levels is a promising strategy to combat these conditions.
How Sabroxy Enhances BDNF Levels
Recent research has demonstrated that Sabroxy can significantly increase BDNF levels. In studies using human neuroblastoma cells (SHSY-5Y), treatment with Sabroxy resulted in an up to 8-fold increase in BDNF expression. This effect was observed even under conditions of inflammation, which typically suppress BDNF production. Sabroxy not only restored BDNF levels but also boosted them significantly, showing its potential as a powerful neuroprotective agent.
The Science Behind Sabroxy
The effectiveness of Sabroxy lies in its ability to act on multiple pathways involved in brain health. The three primary compounds in Sabroxy - oroxylin A, chrysin, and baicalein - work synergistically to enhance BDNF levels and protect neurons.
-Oroxylin A (OA): This compound can cross the blood-brain barrier and has been shown to activate pathways that lead to increased BDNF production. It does this by modulating GABA receptors and adenosine A2A receptors, both of which play roles in neuron survival and function.
-Chrysin (CH): Known for its antioxidant and anti-inflammatory properties, chrysin also modulates estrogen receptors and supports the activation of pathways that lead to BDNF production.
ng>-Baicalein (BA): Like chrysin, baicalein has strong antioxidant and anti-inflammatory effects. It also supports neuron survival by modulating GABA receptors and estrogen receptors, enhancing the overall neuroprotective effect of Sabroxy.
Sabroxy's Antioxidant and Anti-inflammatory Effects
Oxidative stress and inflammation are major contributors to neurodegenerative diseases. Sabroxy has demonstrated significant antioxidant activity, which helps reduce oxidative damage in brain cells. In addition, its anti-inflammatory properties further protect neurons from damage and support overall brain health.
Potential Therapeutic Applications
Given its ability to enhance BDNF levels and protect against oxidative stress and inflammation, Sabroxy shows promise for treating and preventing various neurological conditions. It could be particularly beneficial for:
-Alzheimer's Disease: By boosting BDNF levels and reducing inflammation, Sabroxy may help slow the progression of Alzheimer's and improve cognitive function.
-Parkinson's Disease: The neuroprotective effects of Sabroxy could help protect dopamine-producing neurons, which are damaged in Parkinson's disease.
-Depression: Low BDNF levels are linked to depression, and increasing BDNF with Sabroxy could improve mood and mental health.
Conclusion
Sabroxy, the extract from Oroxylum indicum, offers a natural and effective way to support brain health. By enhancing BDNF levels and providing powerful antioxidant and anti-inflammatory effects, Sabroxy shows great potential as a neuroprotective agent. Further research and clinical studies will help to fully understand its benefits and applications in treating neurological disorders.
The study findings were published in the peer reviewed journal: Nutrients.
https://www.mdpi.com/2072-6643/16/12/1887
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