Nikhil Prasad Fact checked by:Thailand Medical News Team Jun 07, 2024 5 months, 2 weeks, 1 day, 21 hours, 47 minutes ago
COVID-19 News: As the COVID-19 pandemic evolves, understanding the factors that influence disease severity and patient outcomes is crucial. A recent study by researchers from Beijing Ditan Hospital that is covered in this
COVID-19 News report, explores the role of hyaluronic acid (HA) in patients with COVID-19, particularly focusing on its clinical and prognostic implications in both reinfection and first-time infection cases.
Hyaluronic Acid as a Key Biomarker for COVID-19 Mortality
Serum HA levels according to infection status (A), vaccine status (B), viral clearance time (C), and survival status (D). HA, hyaluronic acid.
The Study Setup
The study involved patients admitted to Beijing Ditan Hospital between September 2023 and November 2023. It specifically looked at the differences in HA levels between those experiencing COVID-19 for the first time and those who were reinfected. The researchers aimed to identify whether HA could serve as a biomarker for predicting mortality and long COVID.
Patients were divided into two groups: those with reinfection and those with a first-time infection. Using a propensity score matching algorithm, the researchers matched reinfections to first infections to ensure comparable groups. They collected and analyzed data on clinical outcomes, HA levels, and various laboratory indicators.
Key Findings
-Reinfection vs. First Infection
The reinfection rate among hospitalized patients was 25.4%. Interestingly, reinfection cases exhibited better clinical outcomes compared to first-time infections. Patients with reinfections had lower levels of inflammatory markers such as C-reactive protein and erythrocyte sedimentation rate. They also showed fewer cases of severe lung infiltration, respiratory failure, and had shorter viral clearance times and symptom durations.
-Hyaluronic Acid Levels
One of the critical findings was that HA levels were significantly higher in patients with primary infections compared to those with reinfections. Higher HA levels were also associated with prolonged viral clearance times and higher mortality rates. Specifically, deceased patients had significantly elevated HA levels compared to survivors.
-HA as a Mortality Predictor
The study identified HA as an independent predictor of death in COVID-19 patients. Patients with HA levels above 116 ng/mL had a substantially increased risk of mortality. The researchers suggest that monitoring HA levels in COVID-19 patients could help in early risk stratification and better clinical decision-making.
-Long COVID and HA
The study also explored the relationship between HA levels and the incidence of long COVID. Contrary to some speculations, HA levels did not correlate with long COVID symptoms. Patients with high HA levels did not report higher incidences of long COVID compared to those with lower levels.
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Clinical Implications
The findings of this study have significant clinical implications. HA could serve as a novel biomarker for predicting COVID-19 mortality, helping healthcare providers identify high-risk patients early. This could lead to more personalized and timely interventions, potentially improving patient outcomes.
Conclusion
In summary, the study sheds light on the crucial role of HA in COVID-19 prognosis. While reinfections tend to have better clinical outcomes, elevated HA levels in primary infections signal a higher risk of mortality. However, HA levels do not seem to predict long COVID. These insights contribute to the growing understanding of COVID-19's pathophysiology and highlight the potential of HA as a valuable tool in managing the disease.
The study findings were published in the peer reviewed journal: Frontiers in Microbiology.
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1406581/full
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https://www.thailandmedical.news/news/covid-19-clotting-caused-by-damage-of-small-vessels-and-glycocalyx-which-releases-hyaluronic-acid,-syndecan-1,-p-selectin-that-promotes-agrregation
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