Move Over Ozempic And Wegovy, Fermented Blackberries - The New Anti-Obesity And Weight Loss Remedy
Nikhil Prasad Fact checked by:Thailand Medical News Team Jun 06, 2024 5 months, 2 weeks, 2 days, 16 hours, 57 minutes ago
Weight Loss News: Forget about overpriced Ozempic and Wegovy, aka semaglutide, and Mounjaro, aka tirzepatide,which no one even knows what are the possible long-term effects of their use.South Korean scientist have discovered a safer and cheaper alternative: blackberries fermented with lactobacillus!
Fermented Blackberries - The New Anti-Obesity And Weight Loss Remedy
Blackberries, scientifically known as Rubus fruticosus, are well-celebrated for their antioxidant properties. These berries are packed with bioactive substances and have been linked to numerous health benefits, including anti-inflammatory, anti-atherosclerosis, anti-tumor, and immunomodulatory activities. Despite extensive research on their antioxidant properties, the potential biological effects and precise molecular mechanisms of fermented blackberry extracts remain largely unexplored. In a study that is covered in this
Weight Loss News report, researchers from Jeonju AgroBio-Materials Institute, Chebigen Inc., and Sejong University in South Korea unveil the anti-obesity effects of blackberries fermented with Lactobacillus.
Fighting Obesity with Fermented Blackberries
Obesity, a global epidemic affecting over one billion people, is primarily caused by an increase in adipose tissue mass due to the proliferation of adipocytes. It is associated with numerous metabolic disorders such as cardiovascular diseases, type 2 diabetes, non-alcoholic fatty liver disease, and various forms of cancer. While the FDA has approved several anti-obesity drugs, these often come with side effects like nausea, insomnia, constipation, gastrointestinal issues, and potential cardiovascular complications. Hence, there is a growing need for natural, side-effect-free alternatives to manage obesity.
The Role of Fermented Foods in Health
Fermented foods are rich in bioactive compounds that exhibit therapeutic effects, especially for metabolic disorders. These compounds have been shown to lower lipid levels, reduce blood pressure, and provide anti-inflammatory, immune-boosting, and antibacterial benefits. Fermentation not only preserves food but also enhances its medicinal properties by producing various bioactive chemicals and enzymes not present in raw materials. This study highlights how fermented blackberries can serve as a potent tool in fighting obesity.
The Study: Methodology and Findings
Researchers investigated the effects of blackberries fermented with Lactobacillus on mice fed a high-fat diet (60% kcal) for 12 weeks. The results were promising. Mice administered fermented blackberries showed significant reductions in body weight and epididymal fat compared to the obese group. Additionally, fermented blackberry treatment led to significant decreases in blood lipid indicators like triglycerides and total cholesterol, as well as leptin levels, an insulin resistance indicator.
Molecular Mechanisms: Adipogenesis Inhibition
The study delved into the molecular mechanisms behind the anti-obes
ity effects of fermented blackberries. It was found that the expression of adipogenesis marker proteins such as CEBPα, PPAR-γ, and SREBP-1, which were significantly increased in the obese group, were substantially reduced in the fermented blackberries-treated group. This suggests that fermented blackberries inhibit adipogenesis, the process of cell differentiation that leads to fat accumulation.
Detailed Results: Body Weight and Lipid Accumulation
Histological examinations of white adipose tissues (WATs) and liver tissues revealed significant findings. H&E staining showed a decrease in adipocyte size in fermented blackberries-treated mice. Furthermore, treatments with fermented blackberries reduced hepatic lipid deposition, indicating a preventive effect against adipocyte hypertrophy and lipid accumulation. Serum levels of triglycerides and total cholesterol, which were elevated in the high-fat diet group, were significantly reduced following fermented blackberry administration.
Fermented Blackberries and Insulin Resistance
The study also investigated the effects of fermented blackberries on insulin resistance. High-fat diet-induced increases in leptin and insulin levels were significantly reduced in the fermented blackberries-treated group. This suggests that fermented blackberries can improve insulin sensitivity and reduce the risk of obesity-related metabolic disorders.
The Broader Impact: Mental Health and Beyond
The benefits of fermented blackberries extend beyond weight management. Previous studies have highlighted the antioxidant, anti-inflammatory, and neuroprotective properties of blackberries, which are rich in polyphenols, anthocyanins, and other antioxidants. There is also evidence to suggest that diets rich in anthocyanins, such as those found in blackberries, may have positive mental health outcomes. Given the strong link between obesity and depression, controlling obesity through fermented blackberries could potentially alleviate related mental health issues.
Conclusion: A Promising Natural Remedy
This study robustly endorses the concept that fermented blackberries exert a preventive influence on obesity and its related metabolic complexities. The findings underscore the potential of fermented blackberries as a natural, side-effect-free intervention for managing obesity. Further research is necessary to clarify the underlying mechanisms and enhance the therapeutic effectiveness of fermented blackberries for various health concerns.
In summary, blackberries fermented with Lactobacillus show significant promise as a natural remedy for obesity. By inhibiting adipogenesis and improving metabolic health, these fermented berries offer a potent, side-effect-free alternative to conventional anti-obesity treatments. As the global obesity epidemic continues to rise, the exploration of such natural interventions becomes increasingly vital.
The study findings were published in the peer reviewed International Journal of Molecular Sciences.
https://www.mdpi.com/1422-0067/25/11/6164
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