For All The Latest Medical News, Health News, Research News, COVID-19 News, Dengue News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Cardiology News, Epigenetic News, Cancer News, Doctor News, Hospital News

✖
 ENGLISH
 ENGLISH  THAI
BREAKING NEWS
Source: Thailand Medical News  Jul 15, 2019  5 years, 4 months, 2 days, 13 hours, 49 minutes ago

New Discovery That Antibodies Are The Cause Of Rheumatoid Arthritic Pain

Arthritis
New Discovery That Antibodies Are The Cause Of Rheumatoid Arthritic Pain
Source: Thailand Medical News  Jul 15, 2019  5 years, 4 months, 2 days, 13 hours, 49 minutes ago
Rheumatoid arthritis is an autoimmune disease that occurs when immune cells attack the cartilage and bone of the joints. The disease affects roughly 1.4 percent of the global population. A common symptom is joint pain, but even before that, the body has started to produce immune antibodies against proteins in the joint. Scientists at Karolinska Institute in Sweden, have now discovered  how these autoantibodies can generate pain. The results from this study can facilitate the development of new ways of reducing non-inflammatory pain caused by rheumatoid arthritis and other autoimmune diseases.



The researchers injected cartilage-binding autoantibodies into animal models, which served as a model for human rheumatoid arthritis, and subsequently discovered that the animal models became more sensitive to pain even before they could observe any signs of inflammation in the joints. Antibodies that had been designed not to activate immune cells and trigger inflammation also induced pain-like behaviour in the animal models, suggesting increased pain sensitivity in the joints.

The team found that the antibodies that caused the behavioural change form so called immune complexes, comprising clusters of antibodies and cartilage proteins in the joints. These complexes activate pain cells via so-called Fc-gamma receptors, which the researchers discovered were present on pain neurons in the tissue.When they cultivated pain neurons from the animal models, the team found that the cells were activated when coming into contact with the antibody complexes. The process was dependent upon the Fc-gamma receptors on the neurons but not on the presence of immune cells. Antibodies in complex can thus act as pain-generating molecules in themselves, independently of the activity of the immune cells.

Antibodies in these immune complexes can activate the pain neurons directly, and not, as previously thought, as a result of the destructive joint inflammation. The antibodies can affect the pain neurons also in conditions without any distinct tissue damage or inflammation.Though the study was conducted in animal models, the team show that human pain neurons also have antibody receptors that are functionally similar to those they found on the animal model pain neurons, which leads them to believe that their findings are also relevant to humans.

These findings help explain the early pain symptoms in rheumatoid arthritis patients. However, joint and muscle pain are also common symptoms of other autoimmune diseases, and since this newly discovered mechanism operates through the constant part ie the  autoantibody, the team believe that it can explain non-inflammatory pain caused by other autoimmune diseases too. Further detailed study of what happens in the nerve cell when the antibody complex binds to the receptor could also lead to new targets for reducing the neuronal activity.

One of the researchers holds a patent on the use of a type of antibody used in the study and a royalty agreement with Hansa Medical, which also holds a patent on a particular application of the antibodies.

Reference: Alex Bersellini Farinotti, Gustaf Wigerblad, Diana Nascimento, Duygu B Bas, Carlos Morado Urbina, Kutty Selva Nandakumar, Katalin Sandor, Bingze Xu, Sally Abdelmoaty, Matthew A Hunt, Kristina Ängeby Möller, Azar Baharpoor, Jon Sinclair, Kent Jardemark, Johanna T Lanner, Ia Khmaladze, Lars E. Borm, Lu Zhang, Fredrik Wermeling, Mark S Cragg, Johan Lengqvist, Anne-Julie Chabot-Doré, Luda Diatchenko, I nna Belfer, Mattias Collin, Kim Kultima, Birgitta Heyman, Juan M. Jimenez-Andrade, Simone Codeluppi, Rikard Holmdahl, Camilla I Svensson. Cartilage binding antibodies induce pain through immune complex mediated activation of neurons. Journal of Experimental Medicine, June 13, 2019; DOI: 10.1084/jem.20181657
 

MOST READ

Nov 05, 2024  13 days ago
Nikhil Prasad
Study Reveals That COVID-19 Alters Key Human Genes
Oct 07, 2024  1 month ago
Nikhil Prasad
Study reveals the SARS-CoV-2 spike protein interacts with over 60,000 host proteins and may trigger carcinogenesis!
Aug 08, 2024  3 months ago
Nikhil Prasad
COVID-19 induced endothelial dysfunction will lead to a pandemic of chronic kidney and cardiovascular diseases
Aug 04, 2024  4 months ago
Nikhil Prasad
COVID-19's unexpected impact - Rising orofacial pain among infected individuals
Jul 25, 2024  4 months ago
Nikhil Prasad
Murine study shows how COVID-19 increases risk for stroke
Jul 24, 2024  4 months ago
Nikhil Prasad
COVID-19 can cause Osteomyelitis of the jaw
Jul 22, 2024  4 months ago
Nikhil Prasad
COVID-19 causes Blood DNA Methylation, a potential biomarker for Long COVID severity
Jul 22, 2024  4 months ago
Nikhil Prasad
Doctors from Turkey warns that children exposed to SARS-CoV-2 are at risk of acute kidney injury
Jul 08, 2024  4 months ago
Nikhil Prasad
Unknown To Many Including Doctors, COVID-19 Causes Parsonage Turner Syndrome
Jun 26, 2024  5 months ago
Nikhil Prasad
BREAKING! Mild COVID Causes A Slow Progressing Eye Debilitating Condition That Most Are Not Even Aware Of Till It's Too Late!
Jun 24, 2024  5 months ago
Nikhil Prasad
COVID-19's Hidden Impact on Eyes: Unveiling Rare Retinal Conditions
Jun 23, 2024  5 months ago
Nikhil Prasad
Somnolence And Shingles Seems To Be New Symptom/Manifestation Of COVID-19 KP.3 And LB.1 Infections!
Jun 22, 2024  5 months ago
Nikhil Prasad
Herbs And Phytochemicals: Fermented Codonopsis lanceolata Root Extract Shows Promise Against Influenza A Virus
Jun 12, 2024  5 months ago
Nikhil Prasad
Most Long COVID Patients Likely To Develop New Onset Psychiatric Disease!
Mar 12, 2024  8 months ago
Nikhil Prasad
Mild Or Moderate COVID-19 Causes Accelerated Brain Aging Especially In Young To Early Middle-Aged Adults!
Mar 10, 2024  8 months ago
Nikhil Prasad
Six Percent Of All Post-COVID Patients Who Have Hip Discomfort Likely To Have Developed Avascular Necrosis Of The Femoral Head!
Mar 05, 2024  9 months ago
Nikhil Prasad
Austrian Scientists Claim That High-Density Lipoproteins Can Be Used As Antivirals Against COVID-19 Infections
Feb 20, 2024  9 months ago
Nikhil Prasad
New Measles Variant That Can Evade Current Diagnostics Identified In Italy! More New Strains To Be Announced Soon!
Jan 02, 2024  11 months ago
Nikhil Prasad
BREAKING COVID-19 News! Study Claims That Omicron Infections Can Lead To Acute Primary Angle Closure And Also Primary Angle Closure Glaucoma!
Dec 16, 2023  11 months ago
Nikhil Prasad
BREAKING COVID-19 News! Australian Scientists Discover A microRNA Called CoV2-miR-O8 That Is Encoded By SARS-CoV-2 And Is Possibly Pathogenetic!
Dec 15, 2023  11 months ago
Nikhil Prasad
COVID-19 News: Foods Rich In XeSiAs-Neu5Gc Contributes To Xenosialylation That Causes Worse Outcomes In SARS-CoV-2 Infections And Vaccination!
Oct 23, 2023  1 year ago
Nikhil Prasad
COVID-19 News: SARS-CoV-2 Is Likely An Oncogenic Virus That Will Cause Lung, Colorectal, Oral, Pancreatic And Breast Cancers In The Long Term!
Jun 29, 2023  1 year ago
Medical News - SARS-CoV-2 - IGF2BP1
BREAKING! Scientists Warns That SARS-CoV-2 Also Interacts With IGF2BP1- An Oncofetal RNA-Binding Protein That Typically Fuels Tumor Virus Propagation!
Jun 10, 2023  1 year ago
COVID-19 News - DNA Methylation - Asymptomatic SARS-CoV-2 Infections
BREAKING NEWS! Even Asymptomatic SARS-CoV-2 Infections Cause DNA Methylation And Epigenetic Changes, Leading to Immune Dysregulation!
May 13, 2023  2 years ago
COVID-19 News - Viral Peristence - Long COVID
There Is No Such Thing As Long COVID! SARS-CoV-2 Exposure Causes Persistent Infections Along With Continuous Presence Of Short Viral RNAs (svRNAs)!
Feb 07, 2023  2 years ago
COVID-19 News - Breast Cancer
BREAKING! COVID-19 News: SARS-CoV-2 Infections Lead To Increased Risk Of Breast Cancer, Recurrence Of Breast Cancer And Also Breast Cancer Metastasis!
Nov 29, 2022  2 years ago
COVID-19 News - D-Alanine Supplements Prevents COVID-19 Severity
BREAKING COVID-19 News: Japanese Scientists Find That Supplementation With The Amino Acid D-Alanine Can Help Prevent And Treat COVID-19 Severity!
Sep 28, 2022  2 years ago
Source: Medical News - SARS-CoV-2 Reinfections - Omicron
Study Validates Previous Findings That SARS-CoV-2 Reinfections Are Now Occurring At Shorter Intervals. Current CDC and ECDC Reinfection Definitions Are Obsolete!
Aug 04, 2022  2 years ago
Source: Medical News - SARS-CoV-2 & Cancer
BREAKING! Study Finds That Cancer Causing Genes Are Upregulated In SARS-CoV-2 Infected Individuals!
Jun 27, 2022  2 years ago
Source: Medical News -SARS-CoV-2 Reduces Human Life Spans
BREAKING! Hypothesis That Majority Exposed To SARS-CoV-2 Will Have Shortened Lifespans Validated By Study Showing NSP2 Impairs Human 4EHP-GIGYF2 Complex!
Dec 25, 2021  3 years ago
Source: SARS-CoV-2 Viral Persistence
BREAKING! U.S. NIH Study Shockingly Reveals SARS-CoV-2 Viral Persistence Throughout Human Body And In The Brain Even In Those Who Were Asymptomatic!
Nov 18, 2021  3 years ago
Source: SARS-CoV-2-Cancer
BREAKING! New International Study Warns That SARS-CoV-2 Infections Will Lead To Cancers Especially Colorectal Cancers Due to Disruption In Autophagy!
Dec 17, 2020  4 years ago
Source: COVID-19 News
COVID-19 News: Harvard And MIT Study Alarmingly Shows That SARS-CoV-2 RNA Integrates Into Human Genome With Varying Implications
Nov 13, 2020  4 years ago
Source: COVID-19 Genetics
BREAKING! COVID-19 Genetics: Yale Scientist Identify Eight ‘Super’ Genetic Variants In White People That Increases COVID-19 Death Risk!
Nov 05, 2020  4 years ago
Source: Ozone Water-COVID-19
Japanese Study Shows That Ozone Water Rapidly Inactivates SARS-Cov-2 Coronavirus, Making It An Ideal COVID-19 Disinfectant And Sanitizer
Sep 30, 2020  4 years ago
Source: BREAKING NEWS
BREAKING NEWS! COVID-19 Study Reveals That SARS-CoV-2 Uses CD4 Cells To Infect T-helper Lymphocytes. COVID-19 A Potent Version Of Airborne HIV?

FROM HANTAVIRUS NEWS

LATEST ON HIV / AIDS

World COVID-19 News
COVID-19 Diagnostics
COVID-19 Drugs
COVID-19 Supplements
COVID-19 Herbs
COVID-19 Disinfectants
COVID-19 Mutations
COVID-19 Research
COVID News
Long COVID
COVID-19 Vaccines
COVID-19 Clinical Care
Medical Press Releases
Medical Innovations & Startups
AI in Medicine
Thailand Biotech News
Medical Spheres Bulletins
Medical White Papers
Medical Packages
Medical Tips
Medical Support Groups
Medical Tourism
TNM Aristrocrat Club
Medical Journals
Thai Herbal Products
TMN Medical Mart
Wellness Centers
Rehab Centers
Medsiam App