Source: Thailand Medical News Oct 29, 2019 5 years, 2 weeks, 2 days, 2 hours, 41 minutes ago
Medical researchers at Stevens Institute of Technology, New Jersey, US have developed a technique using shortwave rays used in cellphones and airport security scanners, that detects skin lesions and determines whether they are cancerous or benign, a technology that could ultimately be incorporated into a handheld device that could rapidly diagnose
skin cancer without a scalpel in sight.
Currently, even the best dermatologists can't diagnose
skin cancer by eye, relying on magnifying glasses to examine suspicious blemishes and scalpels to cut tissue for analysis.
The study and development led by Dr Negar Tavassolian, director of the Stevens Bio-Electromagnetics Laboratory, and postdoctoral fellow Amir Mirbeik-Sabzevari, not only has the ability to reduce the number of unnecessary biopsies by 50 percent but also has the potential to disrupt a $5.3 billion diagnostic market for the most common
cancer in the United States, with 9,500 Americans diagnosed with
skin cancer each day.
Dr Negar Tavassolian
The research team's technology uses millimeter-wave radiation, the same shortwave rays used in cellphones and airport security scanners. Millimeter-wave rays penetrate certain materials and bounce off others, which is how airport security knows if you leave your keys in your pocket as you walk through a scanner. Just as metal reflects more energy than your body, so cancerous tumors reflect more calibrated energy than healthy skin, making it possible to identify diseased tissue by looking for reflectivity hotspots.
The recent tests were conducted on biopsies collected by surgeons from Hackensack University Medical Center. Tavassolian and Mirbeik-Sabzevari custom built antennae to generate high-resolution images of this biopsied tissue, and found they could map the tiny tumors as accurately as lab-based testing. Cancerous cells reflected around 40 percent more calibrated energy than healthy tissue, showing that millimeter-wave reflectivity is a reliable marker for cancerous tissue.
Dr Negar Tavassolian commented during an interview with
Thailand Medical News "We've shown proof-of-concept that this technology can be used for rapidly detecting
skin cancer. That's a major step forward toward our ultimate goal of developing a handheld device, which would be safe to use directly on the skin for an almost instant diagnostic reading of specific kinds of
skin cancer including lethal
melanomas based on their individual reflect
ivity signatures."
While the technology underpinning the device is innovative, it's also inexpensive. Since it involves the same basic circuitry within a cellphone, manufacturing costs would be low.
Dr Tavassolian further added "In fact, it should be possible to keep manufacturing costs below $1,000, even at low production volume.That's about the same as the magnifying tools already used by dermatologists, and an order of magnitude cheaper than laser-based imaging tools, which also tend to be slower, bulkier and less accurate than millimeter-wave scanners."
Since millimeter-wave rays penetrate the skin, the scanners can generate real-time 3D images of tumors that could guide surgeons and eliminate the need for multiple trial-and-error biopsies to fully remove cancerous tissue. The devices could also be configured to interpret images automatically, and deliver basic diagnostic information such as a warning to get checked out by a doctor without needing a trained operator.
"We could place these devices in pharmacies, so people can get checked out and go to a doctor for a follow-up if necessary," said Tavassolian. "People won't need to wait weeks to get results, and that will save lives."
Currently, between 2 and 3 million non-melanoma
skin cancers and 132,000
melanoma skin cancers occur globally each year. It is estimated that a 10 per cent decrease in ozone levels will result in an additional 300,000 non-melanoma and 4,500 melanoma
skin cancer cases.
Reference: “High-Contrast, Low-Cost, 3-D Visualization of Skin Cancer Using Ultra-High-Resolution Millimeter-Wave Imaging” by Amir Mirbeik-Sabzevari, Erin Oppelaar, Robin Ashinoff and Negar Tavassolian, 4 March 2019, IEEE Transactions on Medical Imaging.
DOI: 10.1109/TMI.2019.2902600 
