New Study Warns of Neurological Damage by SARS-CoV-2 Spike Proteins from Both COVID-19 Infections and COVID-19 Vaccines
Nikhil Prasad Fact checked by:Thailand Medical News Team Apr 21, 2025 3 hours, 27 minutes ago
Medical News: A groundbreaking review from scientists at Martin Luther University Halle-Wittenberg in Germany is raising serious concerns about the damaging effects of the SARS-CoV-2 spike protein on the human nervous system. Led by Dr. Andreas Posa from the university’s University Clinics and Outpatient Clinics for Radiology, Neuroradiology, and Neurology, the research points to mounting evidence that the infamous spike protein – whether from natural COVID-19 infection or from COVID-19 vaccines – may be responsible for a range of neurological disorders and diseases.
New Study Warns of Neurological Damage by SARS-CoV-2 Spike Proteins from Both COVID-19 Infections
and COVID-19 Vaccines
According to this new study covered in this
Medical News report, while the spike protein (often referred to as SP) plays a central role in enabling the virus to enter human cells by binding to the ACE2 receptor, this very protein has now been shown to also cross the blood-brain barrier and accumulate in the brain, potentially leading to inflammation, neurodegeneration, thrombosis, and damage to brain blood vessels.
Spike Protein and the Brain – A Dangerous Connection
The review emphasizes that spike proteins are capable of crossing the blood-brain barrier (BBB) through a mechanism called adsorptive transcytosis, which allows these viral proteins to slip through even the brain’s most protective shield. Once inside the central nervous system, the spike proteins can bind to brain cells, alter the structure of blood vessels, and initiate a cascade of harmful effects.
Animal studies, postmortem human tissue analysis, and cell culture models all support the finding that both naturally occurring spike proteins and those generated by anti-SARS-CoV-2 products (ASPs), such as mRNA or adenovirus-based vaccines, can enter the brain. The consequences? A complex mix of thrombosis (blood clots), inflammation, cell death, and protein misfolding—hallmarks of neurological and neurodegenerative diseases.
Spike Protein as a Toxin – Key Findings
The study highlights several mechanisms through which spike proteins harm the brain and nervous system:
1. Thrombogenic Effects:
Spike proteins can cause blood clot formation by interacting with platelet integrins and disturbing normal blood flow. These interactions may trigger abnormal clotting even in the brain's small vessels, potentially leading to strokes or other ischemic events.
2. Damage to Brain Endothelial Cells:
SPs attack the inner lining of blood vessels in the brain. They degrade essential junctional proteins, activate inflammatory pathways like NF-κB and toll-like receptors, and increase the expression of leukocyte adhesion molecules. This disrupts the blood-brain barrier, reduces oxygen supply to brain tissues, and results in increased permeability and vascular dysfuncti
on.
3. Neuroinflammatory Processes:
The spike protein activates immune cells in the brain, such as microglia and macrophages, releasing pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6. It also stimulates caspase-1 and engages pattern recognition receptors, promoting chronic inflammation, which is known to contribute to long-term brain damage.
4. Neurodegeneration and Prion-like Effects:
One of the most alarming findings is that spike proteins can bind to and accelerate the aggregation of amyloid-beta, tau, alpha-synuclein, and other proteins implicated in Alzheimer’s, Parkinson’s, and prion diseases. The SP contains prion-like domains and glycine zipper motifs that facilitate the formation of toxic fibrils, which may trigger irreversible brain damage over time.
Spike Proteins from Vaccines – A Similar Threat?
While vaccines were initially hailed as the ultimate weapon against the pandemic, the review raises valid concerns about the long-term safety of mRNA and adenovirus-based COVID-19 vaccines. These vaccines instruct human cells to produce spike proteins to trigger an immune response. However, the spike proteins generated by these vaccines mimic the structure and behavior of the viral spike proteins, including the ability to bind to ACE2 and penetrate the blood-brain barrier.
Crucially, the study notes that these vaccine-induced spike proteins may linger in the body longer than those from the virus itself, owing to genetic modifications that increase their stability and production efficiency. This means that vaccinated individuals could be exposed to spike protein-induced toxicity for a prolonged period—an especially troubling possibility for individuals with underlying conditions or neurological vulnerability.
The Debate Over Safety and Oversight
Another critical aspect addressed by the researchers is the speed with which gene-based vaccines were developed, approved, and rolled out globally. Many safety and toxicological tests required under Good Manufacturing Practices (GMP) were bypassed during the emergency authorization process. This has led to an incomplete understanding of the long-term neurological effects these vaccines may cause.
The study also acknowledges under-reporting issues in vaccine adverse event databases, suggesting that the true frequency of neurological complications post-vaccination may be significantly higher than current figures indicate.
Conclusion – A Call for Vigilance and Further Research
The new evidence presented by Dr. Andreas Posa and his team underscores the need for urgent and rigorous evaluation of the neurological risks associated with both COVID-19 infection and the widespread use of spike protein-based vaccines.
The spike protein’s ability to cause thrombosis, inflammation, and neurodegeneration makes it a molecule of significant concern. While the benefits of vaccination, particularly in high-risk groups, cannot be denied, these findings highlight the importance of personalized medicine, caution in policy decisions, and further in-depth research to ensure long-term public health safety.
The study warns that overlooking these potential neurological consequences could have lasting implications for millions of people globally who were either infected with SARS-CoV-2 or received spike protein-based vaccines. The researchers advocate for increased surveillance of post-infection and post-vaccination neurological health and stress the need to develop safer immunization strategies in the future.
The study findings were published in the peer-reviewed journal: Annals of Anatomy.
https://www.sciencedirect.com/science/article/pii/S0940960225002894
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