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BREAKING NEWS
Nikhil Prasad  Fact checked by:Thailand Medical News Team Apr 13, 2024  8 months, 1 week, 2 days, 20 hours, 54 minutes ago

No Agency Is Prepared! Existing H5N1 Vaccines And Antivirals Like Tamiflu And Xofluza Do Not Work Against The New H5N1 Variants!

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No Agency Is Prepared! Existing H5N1 Vaccines And Antivirals Like Tamiflu And Xofluza Do Not Work Against The New H5N1 Variants!
Nikhil Prasad  Fact checked by:Thailand Medical News Team Apr 13, 2024  8 months, 1 week, 2 days, 20 hours, 54 minutes ago
H5N1 News: While the H5N1 virus has been spreading globally for the last two years at very alarming rates, affecting birds and poultry and evolving to infect other mammals, including dairy cows, cats, and dogs, various health agencies including the U.S. CDC and the U.S. NIH have kept insisting that they are prepared to deal with the situation should an outbreak involving human-to-human transmission occur.


Existing H5N1 Vaccines And Antivirals Like Tamiflu And Xofluza
Do Not Work Against The New H5N1 Variants

 
They claim that they have stockpiles of various H5N1 vaccines licensed by the U.S. FDA in the years 2017 and 2020, as well as stockpiles of Tamiflu and Xofluza.
 
American Authorities Advise Not to Panic Despite the Situation Worsening
The U.S. CDC, U.S. NIH, and even the U.S. FDA have in recent days insisted that there is no cause for panic over the rising cases of dairy cows getting infected in the United States.
 
While the number of cows and farms getting infected is growing by the hour, with now nine states in America already confirmed to have cows infected with a new strain of H5N1 that spots a unique mutation and allows it to spread via the eyes of the host, the American authorities do not seem to be springing into action to do anything except offer mere lip service.
https://www.thailandmedical.news/news/breaking-h5n1-genotype-affecting-cows-in-america-possibly-gains-entry-into-humans-via-the-eyes-thru-the-new-pb2-e67k-mutation
 
H5N1 News reports are already emerging about cats and even dogs getting infected and dying from the H5N1 virus, but there have been no updates on genomic sequencing to see if the virus is still mutating.
 
https://www.thailandmedical.news/news/news-of-cats-dying-from-h5n1-in-texas-raises-alarms-as-dairy-cows-and-even-a-human-have-already-been-infected-with-the-new-strain
 
H5N1 Evolving
The Avian H5N1, a strain of the influenza virus known to infect bird species and poultry globally and has been rising in spread and infections since 2022.
It has started infecting numerous mammalian species globally and even in the United States since 2022 as well.
 
Worryingly, the H5N1 virus has now appeared to have breached a new barrier of inter-mammalian transmission, as seen in what is happening in the United States at the moment.
 
Already one human has been infected in Texas, while recently in Vietnam, a male student died from it despite not having been in contact with any birds or poultry. The student was treated with both Tamiflu and Xofluza but he still died a few days ago.
 
https://www.thailandmedical.news/news/breaking-america-might-emerge-as-the-epicenter-for-a-global-h5n1-outbreak-after-the-avian-virus-infecting-dairy-cows-jumps-to-a-human-in-texas
 
https://www.thailandmedical.news/news/breaking-news-new-subtype-of-h5n1-avian-flu-has-possibly-emerged-in-vietnam
 
https://www.livescience.com/health/flu/21-year-old-student-dies-of-h5n1-bird-flu-in-vietnam
 
The continued transmissions among dairy cows, cats, dogs, and other mammals are very likely to yield newer mutations in the virus, and some scientists warn that we are just one mutation away from it being effectively transmissible between humans.
 
Some even suspect that this has already occurred, but these strains do not have the right viral fitness yet and just need to further evolve!
 
While the U.S. CDC claims that it is still investigating the evolution issues of the current strains in the United States, what is being seen at the moment underscores the adaptability of the H5N1 virus and raises alarm about its potential to further evolve for efficient human transmission.
 
Many ignorant so-called 'experts' and health authorities are claiming that there is a very low risk of H5N1 to the general human population despite having limited understanding of what is currently occurring.
 
No Natural Human Immunity
Humans have no natural immunity to H5N1, and as such, the virus could be very lethal to them.
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-020-01836-y
 
https://journals.aai.org/jimmunol/article/202/2/382/107169/Immune-Responses-to-Avian-Influenza-Viruses
 
However, many health authorities and agencies are claiming to have stockpiles of vaccines, antivirals, and also monoclonal antibodies to deal with a possible outbreak.
 
Nothing In The ‘Arsenal’ Works
However, in reality, nothing that is being mentioned works against the new H5N1 variants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869794/
(Read the study as it talks about a new H5N1 monoclonal not yet approved or available but all existing products do not work.)
 
Already, it is known that even the current multivalent flu vaccines designed to act as a precaution against disease severity and mortality against presently circulating flu strains do not work efficiently as the flu viruses are great at evolving.
 
The so-called stockpiled H5N1 vaccines were not made to handle this current strain of H5N1, which is still evolving. Furthermore, the stockpiles are sufficient for less than 1 percent of the global population; hence they serve no purpose in mitigating a potential outbreak.
 
Furthermore, past studies have shown that these vaccines in the stockpile do not even elicit a proper protective immune response after a single dose, and subsequent doses are not yet known to provide the right efficiency to even prevent flu infection.
https://www.nbcnews.com/health/health-news/bird-flu-spreads-people-existing-vaccines-may-inadequate-rcna72973
 
https://www.sciencedirect.com/science/article/pii/S1477893923000984\
 
The U.S. FDA-approved drugs like Tamiflu and Xofluza have demonstrated to show no efficiency in the past sporadic cases of zoonotic infections of H5N1 to humans in countries like Vietnam, Cambodia, Chile, and Argentina in the last two years! All the infected died except two.
 
Strangely, the U.S. CDC, U.S. NIH, U.S. FDA, WHO, EMA, etc., recently approved the production of mRNA vaccines for H5N1. What strains of H5N1 used are a complete mystery, and so are the reasons as to why!
 
No research is being funded to develop proper broad-spectrum antivirals to deal with a possible H5N1 or a recombinant H5N1 virus outbreak among humans.
 
Many of the current monoclonal antibodies in stockpile to deal with H5N1 are also unlikely to help anyone, including those in vulnerable groups.
https://investors.vir.bio/news/news-details/2023/Vir-Biotechnology-Announces-Topline-Data-from-Phase-2-PENINSULA-Trial-Evaluating-VIR-2482-for-the-Prevention-of-Seasonal-Influenza-A-Illness-07-20-2023/default.aspx
 
H5N1 Diagnostics
The current rapid flu antigen tests that are administered in emergency rooms and many doctors' offices cannot detect H5N1, and there is an urgent need to start preparing for such test kits. In practice, preparations are often made only when an outbreak actually occurs.
 
United States Ill-Prepared
America is totally unprepared for an imminent H5N1 outbreak. In fact, the country is being very complacent despite many of its scientists and academics in the field warning that it is just a matter of months or even weeks before an outbreak occurs.
 
Thailand Medical News does not think that the current H5N1 lineage in cows that are still evolving will be the strain that causes the outbreak but rather a recombinant variant involving either pig, dog, or cat will be the strain that will wreak havoc among humans in the coming time.
 
For the latest H5N1 News, keep logging on to Thailand Medical News.
 

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