Nikhil Prasad Fact checked by:Thailand Medical News Team Nov 28, 2024 2 hours, 21 minutes ago
Anti-Aging News: Researchers from Kyungpook National University in South Korea and the University of Massachusetts in the United States have explored the photoaging protective effects of quercitrin, a compound isolated from the peel of Green Ball apples. This study highlights the compound’s potential to combat premature skin aging caused by ultraviolet (UV) exposure.
Quercitrin from Green Ball Apples and its Protective Role Against Skin Aging
Understanding Photoaging and Its Impact
Photoaging is a common skin condition caused by chronic exposure to ultraviolet B (UVB) rays. Over time, UVB exposure leads to the breakdown of essential skin proteins like collagen, reduces moisture levels, and triggers inflammatory responses. This
Anti-Aging News report delves into how quercitrin can mitigate these effects, offering a promising avenue for maintaining skin health naturally.
Key Findings from the Study
Quercitrin was tested on human dermal fibroblast cells and mouse macrophage cells to evaluate its effectiveness in preventing UVB-induced damage. Several advanced techniques, including enzyme-linked immunosorbent assays (ELISA), quantitative PCR, and Western blot analysis, were employed.
The findings showed that quercitrin had remarkable protective properties:
-Inhibition of Collagen-Degrading Enzymes
UVB exposure typically increases the activity of matrix metalloproteinases (MMPs), enzymes responsible for breaking down collagen and other structural proteins in the skin. Quercitrin significantly reduced the activity of these enzymes, thereby preserving the skin’s integrity.
-Boosting Collagen and Hyaluronic Acid Synthesis
The study revealed that quercitrin enhanced the production of key molecules like collagen type I alpha 2 chain (COL1A2) and hyaluronic acid synthase 2 (HAS2). Both of these are crucial for maintaining the skin’s elasticity and moisture.
-Regulation of Inflammatory Pathways
Chronic inflammation is a hallmark of photoaging. Quercitrin reduced the expression of pro-inflammatory mediators such as nitric oxide (NO), cyclooxygenase-2 (COX-2), and nuclear factor-kappa B (NF-κB). By modulating these pathways, quercitrin alleviated inflammation and supported overall skin health.
-Enhancing Skin Repair Mechanisms
Transforming growth factor beta 1 (TGFB1), a molecule central to tissue repair and collagen synthesis, was significantly upregulated in quercitrin-treated cells. This indicates quercitrin’s potential to not only prevent damage but also promote healing.
Implications for Skin Health
The study underscores the multifaceted benefits of quercitrin in preventing and repairing UVB-induced skin damage. By reducing collagen degradation, increasing synthesis
of structural proteins and moisture-retaining molecules, and minimizing inflammation, quercitrin emerges as a natural and effective solution for combating photoaging.
Conclusions
Quercitrin isolated from Green Ball apple peels represents a promising agent in the fight against skin aging caused by UVB exposure. Its ability to modulate key biological pathways highlights its potential for inclusion in skincare formulations and health products.
In summary:
-Quercitrin protects against collagen degradation by inhibiting MMP activity and enhancing TIMP expression.
-It boosts the synthesis of critical skin components, including collagen and hyaluronic acid.
-Its anti-inflammatory properties help maintain skin health and resilience.
With its natural origins and wide-ranging benefits, quercitrin could pave the way for the development of innovative and sustainable skincare solutions.
The study findings were published in the peer-reviewed journal: Horticulturae.
https://www.mdpi.com/2311-7524/10/12/1258
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