Raspberry Extract Helps Protect Brain Arteries and Reduce Cell Death in Aneurysms
Nikhil Prasad Fact checked by:Thailand Medical News Team Mar 17, 2025 21 hours, 41 minutes ago
Medical News: Scientists Discover Potential of Raspberry Extract for Brain Aneurysm TreatmentA new study has revealed that raspberry natural extract may offer protection for brain artery cells and help reduce cell death in cases of brain aneurysms. Researchers from The First Affiliated Hospital of Xi’an Jiaotong University, China, and Taihe Hospital, Hubei University of Medicine, China, have found that certain compounds in raspberry extract could improve the survival of vascular endothelial cells (VECs) in brain arteries, potentially leading to new treatment strategies.
Raspberry Extract Helps Protect Brain Arteries and Reduce Cell Death in Aneurysms
Brain aneurysms occur when a section of an artery in the brain becomes weak and bulges, increasing the risk of rupture and severe bleeding. Scientists have long been searching for ways to prevent or slow down the progression of aneurysms. This
Medical News report explores how the raspberry extract affects key cellular processes that influence aneurysm development and progression.
Study Findings Show Improved Cell Survival and Reduced Inflammation
The research team conducted laboratory experiments on human brain artery endothelial cells, exposing them to different concentrations of raspberry extract. Their results showed that cells treated with raspberry extract had higher survival rates than untreated cells. The extract helped to suppress apoptosis, the programmed cell death process that can weaken artery walls and contribute to aneurysm growth.
The study also identified seven major active compounds in raspberry extract, including ellagic acid, rutin, quercetin, and kaempferol. These compounds are known for their antioxidant and anti-inflammatory properties, which help to reduce damage to cells and tissues.
One of the key mechanisms observed in the study was the ability of raspberry extract to reduce the levels of harmful inflammatory proteins, including matrix metalloproteinase-9 (MMP-9), interleukin-17A (IL-17A), and endothelin-1 (ET-1). High levels of these proteins can worsen inflammation and contribute to the weakening of blood vessel walls, making aneurysms more likely to rupture.
However, in cells treated with raspberry extract, these harmful proteins were found at significantly lower levels compared to untreated cells.
Activation of the PI3K/AKT Pathway Enhances Cell Protection
Another important finding from the study was that raspberry extract activated the PI3K/AKT signaling pathway, a key biological pathway that helps cells survive and resist damage. The activation of this pathway in brain artery cells suggests that raspberry extract not only protects cells from dying but also strengthens their resilience against harmful conditions that contribute to aneurysm formation.
In addition, the study found that raspberry extract influenced the levels of key apoptosis-related proteins. It reduced the levels of pro-apoptotic proteins such as Bax, Caspase8, Caspase12, and Caspase3, while increasing levels of the anti-apoptotic protein Bcl-2. This shift in protein expression indicates that ras
pberry extract actively helps cells resist premature death, which is crucial for maintaining healthy blood vessels.
Implications for Future Treatment Options
The findings from this study suggest that raspberry extract could be explored as a potential natural therapy for patients at risk of brain aneurysms. By strengthening endothelial cells, reducing inflammation, and preventing excessive cell death, the extract may help slow down aneurysm progression and reduce the risk of rupture.
While these results are promising, the researchers emphasized the need for further studies, including clinical trials, to determine the effectiveness and safety of raspberry extract in real-world applications. If future studies confirm these benefits, raspberry extract may become an important part of treatment strategies for patients with brain aneurysms.
Conclusion
The study provides strong evidence that raspberry natural extract enhances the survival of brain artery endothelial cells and reduces inflammation and apoptosis, which are key contributors to aneurysm development. The ability of raspberry extract to activate the PI3K/AKT pathway and modulate apoptosis-related proteins suggests that it could serve as a protective agent against brain aneurysms. However, further research is necessary to confirm these effects and explore the potential for using raspberry extract in clinical settings.
The study findings were published in the peer-reviewed journal: Pharmacognosy Magazine
https://journals.sagepub.com/doi/full/10.1177/09731296251321210
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