For All The Latest Medical News, Health News, Research News, COVID-19 News, Dengue News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Cardiology News, Epigenetic News, Cancer News, Doctor News, Hospital News

✖
 ENGLISH
 ENGLISH  THAI
BREAKING NEWS
Source: Netherlands Institute for Neuroscience - KNAW  Jan 20, 2019  5 years, 10 months, 1 day, 23 hours, 1 minute ago

Research Gene therapy promotes faster nerve regeneration

News
Research Gene therapy promotes faster nerve regeneration
Source: Netherlands Institute for Neuroscience - KNAW  Jan 20, 2019  5 years, 10 months, 1 day, 23 hours, 1 minute ago
Researchers from the Netherlands Institute for Neuroscience (NIN) and the Leiden University Medical Center (LUMC) have shown that treatment using gene therapy leads to a faster recovery after nerve damage. By combining a surgical repair procedure with gene therapy, the survival of nerve cells and regeneration of nerve fibers over a long distance was stimulated for the first time. The discovery, published in the journal Brain, is an important step towards the development of a new treatment for people with nerve damage.

Research Gene therapy promotes faster nerve regeneration

During birth or following a traffic accident, nerves in the neck can be torn out of the spinal cord. As a result, these patients lose their arm function, and are unable to perform daily activities such as drinking a cup of coffee. Currently, surgical repair is the only available treatment for patients suffering this kind of nerve damage. "After surgery, nerve fibers have to bridge many centimeters before reaching the muscles and nerve cells from which new fibers need to regenerate are lost in large numbers. Most regenerating nerve fiber do not reach the muscles. The recovery of arm function is therefore disappointing and incomplete," explains researcher Ruben Eggers of the NIN.

Combination of treatments

By combining neurosurgical repair with gene therapy in rats, many of the dying nerve cells can be rescued and nerve fiber growth in the direction of the muscle can be stimulated.

In this study, the researchers used regulatable gene therapy with a growth factor that could be switched on and off by using a widely used antibiotic. "Because we were able to switch off the gene therapy when the growth factor was no longer needed, the regeneration of new nerve fibers towards the muscles was improved considerably," says Ruben Eggers.

A stealth gene switch

To overcome the problem of the immune system recognizing and removing the gene switch, the researchers developed a hidden version, a so-called 'stealth switch'. Professor Joost Verhaagen (NIN) explains: "The stealth gene switch is an important step forward towards the development of gene therapy for nerve damage. The use of a stealth switch improves the gene therapy rendering it even safer."

The gene therapy is not yet ready for use in patients. While the ability to switch off a therapeutic gene is a large step forward, the researchers still found small amounts of the active gene when the switch was turned off. Therefore, further research is needed to optimize this therapy.

The research was funded by Wings for Life, the International Spinal Research Trust and a donation from the Dwarslaesiefonds.
 

MOST READ

Nov 08, 2024  13 days ago
Nikhil Prasad
COVID-19 and the Hidden Threat of Cytomegalovirus (CMV) Reactivation
Nov 05, 2024  17 days ago
Nikhil Prasad
Study Reveals That COVID-19 Alters Key Human Genes
Oct 07, 2024  2 months ago
Nikhil Prasad
Study reveals the SARS-CoV-2 spike protein interacts with over 60,000 host proteins and may trigger carcinogenesis!
Aug 08, 2024  4 months ago
Nikhil Prasad
COVID-19 induced endothelial dysfunction will lead to a pandemic of chronic kidney and cardiovascular diseases
Aug 04, 2024  4 months ago
Nikhil Prasad
COVID-19's unexpected impact - Rising orofacial pain among infected individuals
Jul 25, 2024  4 months ago
Nikhil Prasad
Murine study shows how COVID-19 increases risk for stroke
Jul 24, 2024  4 months ago
Nikhil Prasad
COVID-19 can cause Osteomyelitis of the jaw
Jul 22, 2024  4 months ago
Nikhil Prasad
COVID-19 causes Blood DNA Methylation, a potential biomarker for Long COVID severity
Jul 22, 2024  4 months ago
Nikhil Prasad
Doctors from Turkey warns that children exposed to SARS-CoV-2 are at risk of acute kidney injury
Jul 08, 2024  5 months ago
Nikhil Prasad
Unknown To Many Including Doctors, COVID-19 Causes Parsonage Turner Syndrome
Jun 26, 2024  5 months ago
Nikhil Prasad
BREAKING! Mild COVID Causes A Slow Progressing Eye Debilitating Condition That Most Are Not Even Aware Of Till It's Too Late!
Jun 24, 2024  5 months ago
Nikhil Prasad
COVID-19's Hidden Impact on Eyes: Unveiling Rare Retinal Conditions
Jun 23, 2024  5 months ago
Nikhil Prasad
Somnolence And Shingles Seems To Be New Symptom/Manifestation Of COVID-19 KP.3 And LB.1 Infections!
Jun 22, 2024  5 months ago
Nikhil Prasad
Herbs And Phytochemicals: Fermented Codonopsis lanceolata Root Extract Shows Promise Against Influenza A Virus
Jun 12, 2024  5 months ago
Nikhil Prasad
Most Long COVID Patients Likely To Develop New Onset Psychiatric Disease!
Mar 12, 2024  8 months ago
Nikhil Prasad
Mild Or Moderate COVID-19 Causes Accelerated Brain Aging Especially In Young To Early Middle-Aged Adults!
Mar 10, 2024  9 months ago
Nikhil Prasad
Six Percent Of All Post-COVID Patients Who Have Hip Discomfort Likely To Have Developed Avascular Necrosis Of The Femoral Head!
Mar 05, 2024  9 months ago
Nikhil Prasad
Austrian Scientists Claim That High-Density Lipoproteins Can Be Used As Antivirals Against COVID-19 Infections
Feb 20, 2024  9 months ago
Nikhil Prasad
New Measles Variant That Can Evade Current Diagnostics Identified In Italy! More New Strains To Be Announced Soon!
Jan 02, 2024  11 months ago
Nikhil Prasad
BREAKING COVID-19 News! Study Claims That Omicron Infections Can Lead To Acute Primary Angle Closure And Also Primary Angle Closure Glaucoma!
Dec 16, 2023  11 months ago
Nikhil Prasad
BREAKING COVID-19 News! Australian Scientists Discover A microRNA Called CoV2-miR-O8 That Is Encoded By SARS-CoV-2 And Is Possibly Pathogenetic!
Dec 15, 2023  11 months ago
Nikhil Prasad
COVID-19 News: Foods Rich In XeSiAs-Neu5Gc Contributes To Xenosialylation That Causes Worse Outcomes In SARS-CoV-2 Infections And Vaccination!
Oct 23, 2023  1 year ago
Nikhil Prasad
COVID-19 News: SARS-CoV-2 Is Likely An Oncogenic Virus That Will Cause Lung, Colorectal, Oral, Pancreatic And Breast Cancers In The Long Term!
Jun 29, 2023  1 year ago
Medical News - SARS-CoV-2 - IGF2BP1
BREAKING! Scientists Warns That SARS-CoV-2 Also Interacts With IGF2BP1- An Oncofetal RNA-Binding Protein That Typically Fuels Tumor Virus Propagation!
Jun 10, 2023  1 year ago
COVID-19 News - DNA Methylation - Asymptomatic SARS-CoV-2 Infections
BREAKING NEWS! Even Asymptomatic SARS-CoV-2 Infections Cause DNA Methylation And Epigenetic Changes, Leading to Immune Dysregulation!
May 13, 2023  2 years ago
COVID-19 News - Viral Peristence - Long COVID
There Is No Such Thing As Long COVID! SARS-CoV-2 Exposure Causes Persistent Infections Along With Continuous Presence Of Short Viral RNAs (svRNAs)!
Feb 07, 2023  2 years ago
COVID-19 News - Breast Cancer
BREAKING! COVID-19 News: SARS-CoV-2 Infections Lead To Increased Risk Of Breast Cancer, Recurrence Of Breast Cancer And Also Breast Cancer Metastasis!
Nov 29, 2022  2 years ago
COVID-19 News - D-Alanine Supplements Prevents COVID-19 Severity
BREAKING COVID-19 News: Japanese Scientists Find That Supplementation With The Amino Acid D-Alanine Can Help Prevent And Treat COVID-19 Severity!
Sep 28, 2022  2 years ago
Source: Medical News - SARS-CoV-2 Reinfections - Omicron
Study Validates Previous Findings That SARS-CoV-2 Reinfections Are Now Occurring At Shorter Intervals. Current CDC and ECDC Reinfection Definitions Are Obsolete!
Aug 04, 2022  2 years ago
Source: Medical News - SARS-CoV-2 & Cancer
BREAKING! Study Finds That Cancer Causing Genes Are Upregulated In SARS-CoV-2 Infected Individuals!
Jun 27, 2022  2 years ago
Source: Medical News -SARS-CoV-2 Reduces Human Life Spans
BREAKING! Hypothesis That Majority Exposed To SARS-CoV-2 Will Have Shortened Lifespans Validated By Study Showing NSP2 Impairs Human 4EHP-GIGYF2 Complex!
Dec 25, 2021  3 years ago
Source: SARS-CoV-2 Viral Persistence
BREAKING! U.S. NIH Study Shockingly Reveals SARS-CoV-2 Viral Persistence Throughout Human Body And In The Brain Even In Those Who Were Asymptomatic!
Nov 18, 2021  3 years ago
Source: SARS-CoV-2-Cancer
BREAKING! New International Study Warns That SARS-CoV-2 Infections Will Lead To Cancers Especially Colorectal Cancers Due to Disruption In Autophagy!
Nov 13, 2020  4 years ago
Source: COVID-19 Genetics
BREAKING! COVID-19 Genetics: Yale Scientist Identify Eight ‘Super’ Genetic Variants In White People That Increases COVID-19 Death Risk!
Nov 05, 2020  4 years ago
Source: Ozone Water-COVID-19
Japanese Study Shows That Ozone Water Rapidly Inactivates SARS-Cov-2 Coronavirus, Making It An Ideal COVID-19 Disinfectant And Sanitizer
Sep 30, 2020  4 years ago
Source: BREAKING NEWS
BREAKING NEWS! COVID-19 Study Reveals That SARS-CoV-2 Uses CD4 Cells To Infect T-helper Lymphocytes. COVID-19 A Potent Version Of Airborne HIV?

FROM DOCTOR NEWS

LATEST ON MEDICAL SUPPORT GROUPS

World COVID-19 News
COVID-19 Diagnostics
COVID-19 Drugs
COVID-19 Supplements
COVID-19 Herbs
COVID-19 Disinfectants
COVID-19 Mutations
COVID-19 Research
COVID News
Long COVID
COVID-19 Vaccines
COVID-19 Clinical Care
Medical Press Releases
Medical Innovations & Startups
AI in Medicine
Thailand Biotech News
Medical Spheres Bulletins
Medical White Papers
Medical Packages
Medical Tips
Medical Support Groups
Medical Tourism
TNM Aristrocrat Club
Medical Journals
Thai Herbal Products
TMN Medical Mart
Wellness Centers
Rehab Centers
Medsiam App