Researchers Discover Lipoteichoic Acid From Probiotic Lactobacillus Paracasei Which Can Aid In Aging-Related Leaky Gut And Inflammation
Source : Thailand Medical News Dec 10, 2019 4 years, 11 months, 2 weeks, 3 hours, 31 minutes ago
Medical researchers from Wake Forest School of Medicine, North Carolina have identified a dead probiotic that reduces age-related
leaky gut and
inflammation in older animal models.
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The results from the study is published in the journal
GeroScience.
Past research has indicated that
leaky gut, in which microbes and bacteria in the gut leak into the blood stream through holes or cracks in the intestinal lining, causes an increase in low-grade
inflammation, and these conditions are common in older people. This resulting
inflammation is thought to play a role in the development of many age-related diseases, such as diabetes, obesity, cancer, cardiovascular disease and decline in physical and cognitive functions.
Dr Hariom Yadav, Ph.D., assistant professor of molecular biology at Wake Forest School of Medicine and principal investigator of the study told
Thailand Medical News,"We know that probiotics are instrumental in maintaining a healthy gut and preventing leakage, but there isn't much data available to pinpoint which ones work and which ones don't. Determining the strain that is most effective at reducing
leaky gut and
inflammation would help us target more effective strategies to address the problem, and help explain why
probiotics work for some people but not others."
For the study, Yadav's team first screened eight strains of human-origin
probiotics in roundworms, a commonly used model with a short lifespan of 11 to 20 days. They discovered that a strain of
Lactobacillus paracasei (D3-5), even in the non-viable or heat-killed form, extended the roundworms' life span.
The researchers then tested their initial findings in mice. The results showed that feeding heat-killed
D3-5 to older mice prevented high fat diet-induced metabolic dysfunctions, decreased
leaky gut and
inflammation, and improved physical and cognitive functions.
Dr Yadav added, "Not only did we determine which
probiotic strain was the most effective in preventing
leaky gut and
inflammation, we also showed that the dead version of that
probiotic had the same benefits.This is the first-of-its kind study to show that a component
lipoteichoic acid, from the cell wall of a dead probiotic induced changes in the gut microbiome and mucin production, thereby reducing
leaky gut and
inflammation in elderly mice.”
Dr Yadav further added,"We think our findings could be very useful to the food and supplement industries because dead
probiotics have the potential t
o be more stable and have a longer shelf life than live
probiotics."
Dr Yadav has filed a provisional patent application for D3-5.
Already many supplement companies has approached him and there is a high possibility that commercial supplements of
lipoteichoic acid will be available in the shelves as early as the first quarter of 2020.
Reference : Shaohua Wang et al, Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice, GeroScience (2019). DOI: 10.1007/s11357-019-00137-4
