Nikhil Prasad Fact checked by:Thailand Medical News Team Aug 30, 2024 2 weeks, 2 days, 1 hour, 50 minutes ago
Medical News:
The Overlooked Link Between Mpox and Heart Health
As the world continues to grapple with various viral threats, one virus that has recently come under scrutiny is the Mpox virus, previously known as monkeypox. Researchers from the Department of Pharmacy at the School of Medicine, University of Asia Pacific in Dhaka, Bangladesh, are calling attention to a potentially critical connection between Mpox and vascular inflammation. This
Medical News report explores how Mpox could influence the progression of vascular diseases, a concern that has yet to receive the attention it deserves.
Researchers warn of potential threat to vascular and heart health by Mpox virus
Understanding Mpox: More Than Just a Skin Disease
Mpox, a member of the Orthopoxvirus genus, has long been recognized for its impact on the skin and mucous membranes, leading to the characteristic lesions that are often the first signs of the disease. However, recent studies suggest that the virus may have far-reaching effects beyond the skin, particularly on the cardiovascular system.
The researchers propose that Mpox may contribute to vascular inflammation, a condition where the blood vessels become inflamed, leading to a range of cardiovascular issues. This article delves into the study's findings, shedding light on the potential risks posed by Mpox to heart health.
How Mpox Invades the Body: The Mechanisms at Play
Mpox enters the body through multiple viral proteins that attach to specific receptors on host cells, such as glycosaminoglycans like heparan sulfate. Once inside the cells, the virus begins to replicate and produce proteins that can trigger a cascade of immune responses. This immune reaction, while crucial for fighting off infections, can also lead to the release of inflammatory mediators like interleukin (IL)−1, IL‐6, and tumor necrosis factor-alpha (TNF‐α). These mediators, through complex signaling pathways, contribute to the development of vascular inflammation.
The study highlights that endothelial cells, which line the interior of blood vessels, are particularly vulnerable to infection by the Mpox virus. This vulnerability can result in endothelial dysfunction, a condition where the blood vessels lose their ability to function properly, leading to complications such as atherosclerosis - a buildup of fatty deposits inside the arteries that can lead to heart attacks and strokes.
The Role of Inflammatory Mediators in Vascular Inflammation
One of the key findings of the study is the role of inflammatory mediators in exacerbating vascular inflammation. The Mpox virus, by triggering an immune response, can cause the release of various cytokines and chemokines that promote inflammation. This inflammation is not limited to the site of infection but can spread throughout the body, affecting blood vessels and potentially leading to the formation of atherosclerotic plaques.
The researchers emphasize that these plaque
s are more than just fatty deposits; they are a sign of chronic inflammation that can weaken blood vessels and make them more prone to rupture. When this happens, the result can be catastrophic, leading to heart attacks, strokes, and other serious cardiovascular events.
Comparing Mpox to Other Viral Infections: Lessons from COVID-19
The study draws parallels between Mpox and other viral infections, such as COVID-19, which have been shown to cause significant vascular damage. For instance, the coronavirus responsible for COVID-19 has been linked to widespread endothelial dysfunction and vascular inflammation, contributing to the severe cardiovascular complications observed in many patients.
Similarly, the Mpox virus may cause oxidative stress within endothelial cells, leading to an overproduction of reactive oxygen species (ROS). These ROS can damage the cells lining the blood vessels, making them more susceptible to inflammation and the formation of atherosclerotic plaques.
Potential Long-Term Effects of Mpox on Heart Health
The researchers caution that while the respiratory and cutaneous symptoms of Mpox are well-documented, the potential long-term effects on the cardiovascular system are still largely unknown. This is particularly concerning given the role of vascular inflammation in the development of chronic cardiovascular diseases.
Patients with pre-existing conditions such as obesity, hypertension, or a history of smoking may be at even greater risk. The Mpox virus could act as a catalyst, turning acute inflammation into a chronic condition that persists long after the initial infection has cleared. This could lead to a higher incidence of heart disease, strokes, and other vascular complications in individuals who have recovered from Mpox.
The Need for Further Research: A Call to Action
Given the potential risks highlighted in this study, the authors are calling for more research into the link between Mpox and vascular inflammation. They argue that understanding the mechanisms by which Mpox contributes to cardiovascular disease is crucial for developing effective treatments and prevention strategies.
Moreover, the researchers stress the importance of monitoring patients who have recovered from Mpox for signs of vascular inflammation and other cardiovascular issues. Early detection and intervention could help mitigate the long-term health impacts of the virus.
Conclusion: A Silent Threat to Global Health
In conclusion, while Mpox is often viewed as a skin disease, its potential impact on heart health should not be underestimated. The study from the University of Asia Pacific underscores the need for greater awareness and research into the cardiovascular complications associated with Mpox. As we continue to uncover the complexities of this virus, it is clear that its effects may extend far beyond the visible lesions on the skin, posing a silent threat to global health.
The researchers published their warnings as a correspondence in the peer-reviewed journal: Health Science Reports.
https://onlinelibrary.wiley.com/doi/10.1002/hsr2.2223
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Read Also:
https://www.thailandmedical.news/news/evidence-of-cardiac-complications-in-mpox-infections
https://www.thailandmedical.news/news/researchers-warn-that-mpox-monkeypox-virus-is-neuroinvasive
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