Source: Thailand Medical News Dec 06, 2019 6 years, 2 months, 1 week, 4 days, 10 minutes ago
According to a study published in
JAMA Network Open,
Aspirin use three or more times per week is associated with reductions in all-cause, any
cancer, gastrointestinal
cancer, and colorectal
cancer (CRC) mortality among older adults.
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Dr Holli A. Loomans-Kropp, Ph.D., M.P.H., from the National
Cancer Institute in Rockville, Maryland, and colleagues examined the correlation of aspirin use with all-cause, any
cancer, gastrointestinal, and CRC mortality among 146,152 individuals (mean age at baseline, 66.3 years) who were followed for a median of 12.5 years encompassing 1,822,164 person-years.
The medical researchers found that
aspirin use one to three times per month correlated with a reduced risk for all-cause and
cancer mortality compared with no use (hazard ratios, 0.84 and 0.87, respectively). Reduced risks for mortality of all causes, any cancer, gastrointestinal
cancer, and CRC were seen with aspirin use three or more times per week (hazard ratios, 0.81, 0.85, 0.75, and 0.71, respectively). On stratification by body mass index (BMI), aspirin use three or more times per week correlated with a reduced risk for all-cause and any
cancer mortality among those with a BMI of 20 to 24 kg/m² (hazard ratios, 0.82 and 0.86, respectively) and with reduced risk for all-cause, any
cancer, gastrointestinal
cancer, and CRC mortality with a BMI of 25 to 29.9 kg/m² (hazard ratios, 0.82, 0.86, 0.72, and 0.66, respectively).
Dr Holli A. Loomans-Kropp told
Thailand Medical News, "Future studies should further examine the association of BMI with the efficacy of
aspirin as a
cancer preventive agent to adapt to the changing global obesity trends."
One author disclosed financial ties to the pharmaceutical industry.
Reference: Association of Aspirin Use With Mortality Risk Among Older Adult Participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, Holli A. Loomans-Kropp, PhD, MPH1,2; Paul Pinsky, PhD3; Yin Cao, ScD, MPH4; et alAndrew T. Chan, MD, MPH5,6,7,8; Asad Umar, PhD, DVM2 JAMA Netw Open. 2019;2(12):e1916729. doi:10.1001/jamanetworkopen.2019.16729
