Thailand Medical News Team Aug 18, 2023 1 year, 3 months, 4 days, 13 hours, 42 minutes ago
Long COVID: The global aftermath of the COVID-19 pandemic has left a trail of long-term health effects in its wake, with many individuals experiencing persistent symptoms and complications beyond the acute phase of the infection. As the medical community grapples with the challenges posed by Long COVID syndrome, scientists are exploring innovative approaches to managing this complex condition. Among these strategies, dietary polysaccharides have emerged as a promising avenue for alleviating the symptoms and promoting recovery.
Graphical Abstract
Unveiling the Power of Dietary Polysaccharides
A consortium of researchers from prominent institutions such as Guangdong Ocean University-China, Beibu Gulf University-China, Shantou University-China, and BNU-HKBU United International College-China has delved into the potential of dietary polysaccharides in managing Long COVID syndrome. Their findings shed light on the immunomodulatory, antioxidant, antiviral, and prebiotic activities of these natural compounds.
Polysaccharides, intricate carbohydrates found abundantly in nature, have garnered attention for their diverse health benefits. Common varieties such as beta-glucans, inulin, pectin, and fucoidan hold promise due to their unique structures and presence in various sources like mushrooms, garlic, fruits, and marine algae. Over centuries, these compounds have been integral to human diets, characterized by their safety and minimal adverse effects.
Strengthening Immunity and Cellular Recovery
The immune response to SARS-CoV-2, while essential for combating the virus, can inadvertently lead to tissue damage and inflammation, contributing to the severity of Long COVID symptoms. Polysaccharides, however, present a multifaceted approach to mitigating these effects.
Studies have revealed that polysaccharides like glucan, fructan, fucoidan, carrageenan, and pectin possess immunomodulatory properties. These substances interact with immune cells, modulating their functions and activation. Notably, natural killer cells, macrophages, and T cells - crucial components of the immune arsenal - can benefit from polysaccharide intervention, potentially aiding in the recovery of Long COVID patients.
Moreover, polysaccharides have demonstrated the ability to stimulate the production of interferons, critical molecules that orchestrate antiviral responses. Through this mechanism, these compounds enhance the body's defense against viral infections, promoting a faster recovery process.
Combatting Oxidative Stress and Antiviral Action
Oxidative stress, a process marked by an imbalance between free radicals and antioxidants, has been identified as a significant contributor to the
lingering effects of COVID-19. Polysaccharides offer a powerful solution by acting as antioxidants, neutralizing harmful free radicals and supporting cellular health.
The researchers have elucidated the role of polysaccharides in directly inhibiting the binding between the viral spike protein and ACE2 receptors on host cells. By preventing viral entry, these compounds provide a means to mitigate the duration and severity of post-COVID-19 symptoms.
Nurturing Gut Health for Holistic Recovery
A remarkable aspect of the study focuses on the prebiotic activities of polysaccharides. Emerging evidence underscores the critical role of gut microbiota in overall health, with disruptions linked to various organ systems. In the context of
Long COVID syndrome, maintaining a healthy gut microbiota proves pivotal.
Polysaccharides contribute to gut health by promoting the growth of beneficial bacteria and enhancing the production of short-chain fatty acids (SCFAs). The restoration of a balanced gut microbiota, achieved through the consumption of polysaccharide-rich foods, holds potential for ameliorating Long COVID symptoms and facilitating a comprehensive recovery process.
A Glimpse into the Future
The research conducted by the distinguished team of scientists heralds a new era in Long COVID-19 syndrome management. The multifaceted properties of dietary polysaccharides offer a holistic approach, targeting immune modulation, oxidative stress reduction, antiviral action, and gut health restoration.
As the world grapples with the aftermath of the pandemic, the findings of this study are poised to spark a revolution in treatment strategies. With further research, the potential of dietary polysaccharides to ameliorate Long COVID symptoms may lead to the development of specialized functional foods and dietary supplements. These interventions could play a pivotal role in bolstering the immune system, mitigating oxidative stress, restoring gut microbiota balance, and facilitating organ healing in Long COVID-19 patients.
In conclusion, the journey towards conquering the effects of Long COVID-19 syndrome takes a significant stride forward through the exploration of dietary polysaccharides. These natural compounds possess the innate ability to restore balance within the body, paving the way for a brighter, healthier post-pandemic future. As research in this domain progresses, the potential for polysaccharides to revolutionize the treatment landscape grows, offering hope and healing to countless individuals worldwide.
The study findings were published in the peer reviewed journal: Biomedicine and Pharmacotherapy.
https://www.sciencedirect.com/science/article/pii/S0753332223011113
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