Texas Study Finds That SARS-CoV-2 Literally Damages The Testes And Testicular Tissues In A Variety Of Ways And Also The Blood-Testes Barrier!
Medical News - SARS-CoV-2 - Testicular Tissues - Testes - Damage Jun 30, 2023 1 year, 5 months, 3 weeks, 6 days, 16 hours, 56 minutes ago
Study Reveals Damaging Effects of SARS-CoV-2 on Testes and Male Reproductive Health
Medical News: In the ongoing battle against the COVID-19 pandemic, scientists and researchers have made significant strides in understanding the virus and its impact on the human body. While the focus has primarily been on respiratory complications, a new study conducted by the University of Texas Medical Branch in Galveston-USA has shed light on the detrimental effects of SARS-CoV-2 on the testes and testicular tissues.
Pic Credit: Shutterstock/Staras
The study, which examined both autopsy cases and animal models, uncovered compelling evidence of testicular disease caused by COVID-19. It revealed that the virus can infiltrate non-respiratory organs, including the male reproductive tract, leading to a range of pathological alterations and disruption of the blood-testes barrier (BTB).
Previous autopsy studies have shown the presence of viral RNA in multiple organs, including the testes, up to several months after the onset of symptoms.
Additionally, the study found inflammatory cell infiltration and damage to spermatogenic cells in the testes of severe COVID-19 cases. These findings indicate that SARS-CoV-2 is not limited to the respiratory system but can cause systemic infections.
The researchers identified the receptor angiotensin-converting enzyme 2 (ACE2) as a key player in the infection of the male reproductive tract. ACE2, which is abundantly expressed in testicular cells, facilitates the entry of the virus into the cells. This could explain why men are more susceptible to severe illness and higher mortality rates compared to women.
Furthermore, comorbidities such as diabetes, obesity, hypertension, and cardiovascular disease were found to increase the risk of testicular damage in individuals with COVID-19. These pre-existing conditions, coupled with the viral infection, can lead to inflammation and compromise male reproductive health.
The study also highlighted the impact of SARS-CoV-2 on semen parameters. COVID-19 patients exhibited low sperm counts, reduced sperm motility, and elevated levels of proinflammatory cytokines in their semen. These effects can have long-term implications for fertility and reproductive health.
The research further explored the role of the local immune response in testicular damage. Inflammatory cytokines and immune cells were found to contribute to the destruction of germ cells, impaired spermatogenesis, and damage to the blood-testis barrier. Mast cells, in particular, were identified as potential mediators of testicular damage in COVID-19 patients.
Thailand
Medical News had been warning about SARS-CoV-2 effects on the male reproductive system as early as February 2020 but garbage fact checkers employed by Facebook and also a certain trash male Italian journalist claimed that our articles were fake news! But since then so many other studies have validated our claims and also showe
d that SARS-CoV-2 is able to affect men’s sexual and reproductive health in a variety of ways!
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While this new study provides significant insights into the effects of SARS-CoV-2 on the testes, further research is necessary to establish conclusive data. Future investigations should focus on larger sample sizes and examine the long-term consequences of testicular damage caused by COVID-19.
Understanding the impact of SARS-CoV-2 on male reproductive health is crucial for developing appropriate preventive and therapeutic strategies. By unraveling the mechanisms of testicular damage, scientists can work towards mitigating the long-term effects of the virus on fertility and overall reproductive well-being.
The study review findings were published in the peer reviewed journal:Frontiers In Reproductive Health.
https://www.frontiersin.org/articles/10.3389/frph.2023.1229622/full
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