Thailand Study Finds That Cannabis Sativa Leaf Oil Provides Cardiovascular Benefits in Hypertension
Nikhil Prasad Fact checked by:Thailand Medical News Team Feb 24, 2025 4 hours, 53 minutes ago
Thailand Cannabis News: A Natural Solution for High Blood Pressure?
Researchers from Khon Kaen University in Thailand have made a significant discovery in the fight against hypertension. Their latest study suggests that Cannabis sativa L. leaf oil (HLO) might hold potential for protecting the cardiovascular system, especially in cases of high blood pressure. This
Thailand Cannabis News report delves into their findings and explains how this natural extract could be beneficial.
Thailand Study Finds That Cannabis Sativa Leaf Oil Provides Cardiovascular Benefits in Hypertension
Understanding Hypertension and Vascular Health
Hypertension, or high blood pressure, is a chronic condition that can lead to severe health problems such as heart disease and stroke. One of the main causes of hypertension is the imbalance in nitric oxide levels, a crucial molecule that helps regulate blood vessel function. When nitric oxide production is inhibited, blood vessels become constricted, leading to increased blood pressure. This study used an experimental model where nitric oxide synthesis was deliberately blocked in rats, mimicking a hypertensive condition. Researchers then investigated whether HLO could counteract these harmful effects.
How the Study Was Conducted
The research team divided rats into different groups, including a control group and several groups that received both a nitric oxide inhibitor and varying doses of hemp leaf oil. Over a period of five weeks, the team monitored the rats’ blood pressure, heart function, and vascular health. They also analyzed key biochemical markers linked to oxidative stress and inflammation, both of which play a role in hypertension.
Key Findings: Lower Blood Pressure and Healthier Hearts
The results were compelling. Rats that received HLO showed a significant reduction in blood pressure compared to those that did not receive the extract. Specifically, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were all lowered in the HLO-treated groups. Additionally, the heart’s structure and function were better preserved. The study found that HLO:
-Prevented an increase in blood pressure over time
-Improved heart function, including better heart wall thickness and overall cardiac performance
-Enhanced vascular health by reducing arterial wall thickening and improving blood vessel relaxation
-Reduced oxidative stress and inflammation, two factors that contribute to hypertension and heart disease
The Role of Bioactive Compounds in HLO
HLO contains various beneficial compounds, including phenolic compounds, flavonoids, and quercetin. These bioactive components are known for their antioxidant and anti-inflammatory properties. Researchers believe that HLO works by restoring nitric oxide levels, reducing oxidative stress, and modulati
ng the renin-angiotensin system, a key regulator of blood pressure. The study found that HLO decreased levels of angiotensin II, a molecule that promotes blood vessel constriction and increases blood pressure. Additionally, it lowered the activity of NADPH oxidase, an enzyme associated with oxidative stress and vascular damage.
Implications for Human Health
While this study was conducted on animals, the findings suggest that HLO could be a promising natural remedy for managing hypertension in humans. However, further research, including clinical trials, is needed to determine the safety and effectiveness of HLO for human use. If these findings translate to humans, HLO could become an alternative or complementary therapy for individuals struggling with high blood pressure.
Final Thoughts
Hypertension is a growing global health concern, and current treatments often come with side effects. The discovery that hemp leaf oil may help regulate blood pressure and improve heart health offers hope for those looking for natural alternatives.
The study findings were published in the peer-reviewed International Journal of Molecular Sciences.
https://www.mdpi.com/1422-0067/26/5/1897
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