The anti-inflammatory power of probiotic Lactiplantibacillus plantarum Z22 found in fermented vegetables
Nikhil Prasad Fact checked by:Thailand Medical News Team Oct 27, 2024 1 month, 2 weeks, 1 day, 17 hours, 56 minutes ago
Medical News: Recent research has highlighted the power of probiotics not only in gut health but also as agents in the battle against inflammation. A new study focuses on Lactiplantibacillus plantarum Z22, a probiotic strain isolated from naturally fermented mustard, revealing its potential as a future supplement to improve digestive health and combat chronic inflammation.
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The anti-inflammatory power of probiotic Lactiplantibacillus plantarum Z22 found in fermented vegetables
Researchers from Hunan Agricultural University and Hunan Biological Electromechanical Vocational College in China conducted this research, bringing to light important mechanisms in the probiotic’s action against inflammatory pathways. This
Medical News report explores the study’s findings and how this promising strain could become a powerful tool in health supplements.
What the Study Found
The researchers, who conducted their experiments on L. plantarum Z22, discovered that this strain has unique probiotic properties that make it stand out. They found that it can survive acidic environments, such as those found in the stomach, and resist bile salts, making it resilient enough to thrive in the human digestive system.
The study showed that this strain reduced inflammation in laboratory cells stimulated to mimic inflammation. Specifically, L. plantarum Z22 decreased the release of pro-inflammatory molecules, including IL-6, IL-1β, and TNF-α, which are often linked to chronic inflammatory conditions. These effects were attributed to the strain’s ability to reduce oxidative stress—an imbalance that often fuels inflammation. In addition, this strain contained specific genes known to assist in fighting inflammation and protecting cells from oxidative damage, which were identified through whole-genome sequencing.
How Lactiplantibacillus plantarum Z22 Works
The study goes in-depth on the pathways involved in inflammation and how this strain intervenes. When cells experience inflammation, specific pathways are activated, such as NF-κB and MAPK, which then cause inflammation-related genes to become active. This results in the release of inflammatory markers that promote an immune response, which can sometimes become excessive and lead to chronic inflammation.
By testing L. plantarum Z22 on cells treated with lipopolysaccharides (a compound known to stimulate inflammation), the researchers observed that this strain could significantly inhibit these pathways. As a result, inflammatory molecules like COX-2, a mediator that often amplifies inflammation, were reduced. L. plantarum Z22 also increased the production of HO-1, an enzyme with antioxidant properties that helps combat oxidative stress and thereby further reduces inflammation.
The Genetic Profile of Lactiplantibacillus plantarum Z22
To understand why L. plantarum Z22 had such robust effects, the team performed a detailed genetic analysis. The genome sequenc
ing revealed genes responsible for anti-inflammatory and antioxidant functions. Some of the notable genes include those coding for beta-glucosidase and pyruvate kinase, both of which have known roles in reducing inflammation and protecting cells from oxidative stress. Additionally, genes like thioredoxin reductase help in maintaining cell stability under stress.
This genetic profile supports the strain’s ability to survive and provide benefits in the human digestive system, suggesting its potential application as a functional ingredient in fermented foods or health supplements aimed at reducing inflammation and supporting gut health.
The Implications of the Findings
The findings of this study suggest that Lactiplantibacillus plantarum Z22 could offer a natural, dietary means to support immune health and reduce chronic inflammation. Such a probiotic could be beneficial for people at risk of inflammation-related conditions, such as cardiovascular disease, certain cancers, and autoimmune disorders. Because inflammation is a common factor in many chronic diseases, a probiotic like L. plantarum Z22 could potentially help in preventive health.
Conclusion
In conclusion, Lactiplantibacillus plantarum Z22 shows strong potential as a probiotic supplement that not only benefits the gut but also acts against inflammation. Its survival in acidic conditions, ability to adhere to gut cells, and genetic traits make it a promising candidate for probiotic products aimed at reducing inflammation and supporting digestive health. Future studies, especially those involving human trials, will be essential to confirm its effectiveness in real-world applications.
The study findings were published in the peer-reviewed journal: Microorganisms.
https://www.mdpi.com/2076-2607/12/11/2159
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https://www.thailandmedical.news/news/thailand-medical-researchers-discover-that-lactobacillus-acidophilus-can-prevent-kidney-stone-development
https://www.thailandmedical.news/news/south-korean-study-finds-that-lacticaseibacillus-rhamnosus-hdb1258-boosts-immunity-and-improves-gut-health
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