The Phytochemical 27-Hydroxymangiferolic Acid from Mangoes Can Extend Lifespan and Improve Brain Health
Nikhil Prasad Fact checked by:Thailand Medical News Team Feb 24, 2025 5 hours, 49 minutes ago
Medical News: Natural Compound from Mangoes Could Hold Key to Longer Life
A recent scientific study has revealed that a compound naturally found in mangoes, known as 27-hydroxymangiferolic acid (27-HMA), may have the ability to extend lifespan and improve neurodegenerative conditions. Researchers from the School of Pharmacy at Shanghai University of Traditional Chinese Medicine in China and the School of Agriculture and Medicine at Hebei Open University in China conducted the study to explore the effects of 27-HMA on the tiny roundworm Caenorhabditis elegans. The findings provide new insights into how this compound could potentially enhance health and longevity.
The Phytochemical 27-Hydroxymangiferolic Acid from Mangoes Can Extend Lifespan and Improve Brain Health
Study Reveals Lifespan-Extending Properties of 27-HMA
Scientists have been searching for ways to slow down aging and reduce the occurrence of age-related diseases. One of the most promising approaches involves targeting biological pathways that regulate longevity. This
Medical News report highlights that 27-HMA is a natural activator of a special group of proteins called nuclear receptors, which play a key role in maintaining health at the cellular level. The research focused on how this compound influences the lifespan of Caenorhabditis elegans, a widely used model organism for aging studies.
The study found that when these microscopic worms were given 27-HMA, their lifespan increased significantly. The most noticeable effects were observed at a concentration of 100 micromolar, which extended their lifespan by 16.67%. Further analysis suggested that this compound works by activating nuclear hormone receptors, specifically nhr-8 and daf-12, which are similar to nuclear receptors found in humans. These receptors are known to regulate genes involved in detoxification, stress resistance, and metabolism.
Mechanisms Behind the Longevity Effect
The researchers discovered that 27-HMA extends lifespan through several key mechanisms. It activates the farnesoid X receptor (FXR), which is responsible for controlling bile acid balance, lipid metabolism, and resistance to stress. The compound was found to significantly improve energy homeostasis and detoxification processes in the worms. When the nhr-8 and daf-12 genes were inactivated, the lifespan-extending effects of 27-HMA disappeared, confirming that these nuclear receptors play a crucial role in the process.
Moreover, 27-HMA was found to influence important biological pathways such as the insulin/insulin-like growth factor-1 signaling (IIS) and TORC1 pathways. These pathways are well known for their roles in regulating metabolism, stress responses, and aging. The compound also enhanced the expression of genes related to antioxidant defense, helping the worms resist oxidative stress, which is a major contributor to aging.
Protection Against Neurodegenerative Diseases
In addition to promoting longevity, 27-HMA was tested on worm models of Alzheimer&rsq
uo;s and Parkinson’s diseases. The study showed that 27-HMA improved symptoms associated with these neurodegenerative conditions. In Alzheimer’s models, the compound reduced the buildup of toxic proteins and delayed paralysis in the worms. Similarly, in Parkinson’s models, it protected against dopamine neuron degeneration and improved motor function. These effects were linked to the activation of nuclear hormone receptors and the enhancement of detoxification processes.
Potential Implications for Human Health
While the study was conducted on worms, the findings offer promising possibilities for human health. The ability of 27-HMA to activate nuclear receptors and improve longevity-related pathways suggests that it could be explored for its potential benefits in humans. Researchers believe that further studies on mammals, and eventually clinical trials in humans, could determine whether this mango-derived compound has similar effects in higher organisms.
The implications of this research extend beyond aging and longevity. Given that 27-HMA improved neurodegenerative conditions in worms, scientists are hopeful that it may offer new treatment possibilities for diseases such as Alzheimer’s and Parkinson’s. If future studies confirm these benefits in humans, 27-HMA could become a valuable natural compound for promoting overall health and brain function.
Conclusion
The discovery that 27-HMA, a compound found in mangoes, may extend lifespan and improve brain health opens up new possibilities for aging research. By activating nuclear hormone receptors, this compound enhances detoxification, boosts stress resistance, and improves metabolic processes. Additionally, its protective effects against Alzheimer’s and Parkinson’s models suggest it may have therapeutic potential for neurodegenerative diseases. More research is needed to determine whether these effects translate to humans, but the findings offer an exciting glimpse into how natural compounds can influence health and longevity.
The study findings were published in the peer-reviewed journal: Molecules.
https://www.mdpi.com/1420-3049/30/5/1010
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