The Phytochemical Mogroside V from Monk Fruit Found to Slow Down Aging Damage in Body Cells and Organs
Nikhil Prasad Fact checked by:Thailand Medical News Team Apr 18, 2025 1 day, 5 hours, 25 minutes ago
Medical News: A group of researchers from the School of Basic Medicine, College of Pharmacy, and College of Clinical Medicine at Guilin Medical University in Guangxi, China, have uncovered groundbreaking evidence that mogroside V, a natural compound found in monk fruit, may help slow down or even reverse the damage caused by oxidative aging in cells and vital organs.
The Phytochemical Mogroside V from Monk Fruit Found to Slow Down Aging Damage in Body Cells and Organs
Mogroside V is a plant-derived antioxidant known for its intense sweetness and medicinal properties. It’s extracted from Siraitia grosvenorii, a fruit widely consumed in southern China. While traditionally used as a natural sweetener, modern science is now uncovering its remarkable ability to fight aging at a cellular level. This
Medical News report explores how the compound works at the molecular level to reduce inflammation, prevent cell death, and restore organ health.
Oxidative Aging and Why It Matters
Oxidative aging happens when harmful molecules known as reactive oxygen species (ROS) build up in the body. These molecules damage cells, cause chronic inflammation, and are linked to diseases such as Alzheimer’s, atherosclerosis, liver failure, and more. When the body’s natural defenses—like enzymes such as superoxide dismutase (SOD) and glutathione (GSH)—are weakened, this imbalance triggers premature aging and cell death.
To investigate how mogroside V helps combat this, researchers used both human liver cells and mice that had been artificially aged using a chemical called D-galactose. This model simulates the oxidative stress and cellular damage typically seen in aging organs.
Lab Results Show Mogroside V Reverses Cell Damage
In laboratory cell experiments, mogroside V significantly reduced cell death and restored cell growth. It also increased the levels of SOD and GSH—key antioxidant molecules—while reducing levels of malondialdehyde (MDA), a toxic compound that accumulates during oxidative stress. Moreover, the activity of a known aging marker, SA-β-galactosidase, was dramatically lowered.
In mice, those treated with mogroside V showed healthier liver, kidney, and small intestine tissues. Compared to untreated mice, they had more balanced antioxidant levels, less tissue inflammation, and better organ structure. These effects were seen most clearly at a daily dose of 100 mg per kg of body weight.
Mogroside V Regulates Aging Pathways in the Body
One of the most striking findings was how mogroside V affected key genetic pathways involved in aging. The researchers found that mogroside V blocked the EGFR/p38/JNK pathway in cells—a known trigger of oxidative stress and inflammation. In mice, it also balanced the levels of genes such as c-Jun (which promotes inflammation) and Ptp1b (which helps protect against aging-related diseases).
These molecular cha
nges weren’t just limited to internal organs. The compound also improved the gut microbiota, increasing levels of helpful bacteria like Bacteroidales and Lactobacillaceae, while reducing harmful strains that contribute to aging, inflammation, and gut-brain axis disorders.
Sweet Fruit Compound Could Be the Future of Anti-Aging Therapies
What makes mogroside V especially promising is that it’s both effective and naturally derived. Unlike many synthetic antioxidants, it doesn’t rely on harsh chemical reactions or risky side effects. Instead, it works by gently tuning the body’s antioxidant response and restoring balance at the molecular level.
The findings suggest mogroside V can reduce oxidative stress, prevent organ damage, lower cell death, and even improve gut health—all key components of aging. The researchers hope this compound may someday be used in clinical treatments for age-related conditions or as a supplement to promote healthy aging.
Conclusion
This study clearly demonstrates that mogroside V has the ability to delay or reverse oxidative aging by targeting multiple pathways. It not only enhances the body’s own antioxidant defenses but also regulates harmful genes and restores gut health. These results suggest that mogroside V could be a powerful natural ally in the fight against age-related diseases. However, more human studies are needed to confirm its safety and effectiveness in clinical settings. Until then, this natural compound offers a promising glimpse into future treatments for slowing down the biological clock.
The study findings were published in the peer reviewed journal: Artificial Cells, Nanomedicine, and Biotechnology.
https://www.tandfonline.com/doi/full/10.1080/21691401.2025.2486752
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