University of Mississippi Study Shows That Juice of the Cornelian Cherry Can Help With Glioblastoma
Nikhil Prasad Fact checked by:Thailand Medical news Team Jun 26, 2024 5 days, 1 hour, 14 minutes ago
Herbs And Phytochemicals: A Berry Good Discovery
In an exciting development for cancer research, a new study led by researchers from the University of Mississippi-USA has found that the juice of the Cornelian cherry may have significant benefits for those battling glioblastoma, a highly aggressive type of brain tumor. This discovery offers a glimmer of hope in the fight against one of the most challenging cancers to treat.
University of Mississippi Study Shows That Juice of the Cornelian
Cherry Can Help With Glioblastoma
What is Glioblastoma?
Glioblastoma is known for being particularly tough to treat. It is a fast-growing brain tumor that invades surrounding brain tissue, making complete surgical removal nearly impossible. Despite aggressive treatments, including surgery, radiation, and chemotherapy, the survival rate for glioblastoma remains very low, often leaving patients with a prognosis of just over a year after diagnosis.
The Search for New Treatments
Given the poor outcomes with current treatments, researchers are constantly looking for new ways to combat this formidable disease. Recently, the spotlight has turned towards
Herbs And Phytochemicals, which have shown promise in various cancer studies. This brings us to the Cornelian cherry, a fruit that has been traditionally valued for its medicinal properties.
The Study: A Closer Look
The study, led by Dr Drazen Raucher and a team of researchers from the University of Mississippi Medical Center and other institutions, focused on the effects of juices from three types of stone fruits: tart cherry, Cornelian cherry, and blackthorn. They specifically looked at how these juices affected two glioblastoma cell lines: U87-MG and GBM43.
The results were promising, especially for the Cornelian cherry juice. It demonstrated a strong ability to inhibit the growth of GBM43 cells, even more effectively than temozolomide (TMZ), the current standard chemotherapy drug for glioblastoma.
Why Cornelian Cherry?
What makes Cornelian cherry juice stand out is its high content of iridoids, particularly loganic acid, which are compounds known for their anti-inflammatory and antioxidant properties. While tart cherry juice is rich in anthocyanins and proanthocyanidins, which are also beneficial, it was the iridoids in Cornelian cherry that seemed to pack the most punch against glioblastoma cells.
The Science Behind the Juice
To understand why Cornelian cherry juice is so effective, it's helpful to delve into the science. The juice's high iridoid content contributes to its powerful antioxidant activity, which helps protect cells from damage. This is crucial in fighting cancer, as antioxidants can neutralize harmful free radicals that can lead to cancer development.
Furthermore, the study found that Cornelian cherry juice was particularly effective against TMZ
-resistant GBM43 cells. This is a critical finding, as resistance to TMZ is a significant hurdle in treating glioblastoma. The ability of Cornelian cherry juice to inhibit these resistant cells suggests it could be a valuable addition to current treatment protocols.
Antioxidant Power
The researchers evaluated the antioxidant activity of the juices using several methods, including ABTS, DPPH, FRAP, and CUPRAC assays. These tests measure how well the juices can neutralize free radicals and reduce oxidative stress, which is linked to cancer progression.
Cornelian cherry juice showed the highest antioxidant activity in the DPPH assay, indicating its strong potential to combat oxidative stress. This antioxidant power, combined with its iridoid content, makes it a formidable contender in the fight against glioblastoma.
Moving Forward: Potential for Treatment
While these findings are promising, more research is needed to fully understand the potential of Cornelian cherry juice in treating glioblastoma. Future studies will likely explore how these bioactive compounds can be isolated and potentially used in combination with existing treatments to enhance their efficacy.
A New Hope
The discovery that Cornelian cherry juice can significantly inhibit glioblastoma cell growth offers new hope for patients and researchers alike. This natural remedy, with its potent bioactive compounds, could pave the way for new, less toxic treatments for this devastating disease.
Conclusion: A Fruitful Future
The results of this study highlight the potential of natural compounds in the fight against cancer. As researchers continue to explore the benefits of Cornelian cherry juice and other natural remedies, we move closer to finding more effective and less harmful treatments for glioblastoma. This berry good news is a testament to the power of nature in providing solutions to some of our most challenging health problems.
The study findings were published in the peer reviewed journal: Processes
https://www.mdpi.com/2227-9717/12/7/1310
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Herbs And Phytochemicals, keep on logging to Thailand Medical News.
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