Vitisin A from Aged Red Wine Found to be More Effective Than Cyanidin 3-O-Glucoside in Reducing Triglyceride Levels
Nikhil Prasad Fact checked by:Thailand Medical News Team Feb 13, 2025 4 hours, 15 minutes ago
Medical News: A new study conducted by scientists from the Department of Food Science and Engineering at Jinan University in China has revealed that vitisin A, a naturally occurring phytochemical compound found in aged red wine, is significantly more effective at lowering triglyceride levels than cyanidin-3-O-glucoside (C3G), a widely known anthocyanin found in dark-colored fruits and vegetables. This
Medical News report details how vitisin A can help combat high triglyceride levels, a major risk factor for cardiovascular diseases.
Vitisin A from Aged Red Wine Found to be More Effective Than Cyanidin 3-O-Glucoside in Reducing Triglyceride Levels
Understanding Triglycerides and Why They Matter
Triglycerides are a type of fat found in the blood, serving as a key energy source for the body. However, excessive levels can lead to health issues such as heart disease, obesity, and fatty liver disease. Hypertriglyceridemia, the condition of having high triglycerides, has been linked to increased risks of atherosclerosis, diabetes, and pancreatitis. The study sought to explore how vitisin A could offer a more effective approach to lowering these fat molecules in the body.
Vitisin A Shows Stronger Triglyceride Reduction Than C3G
The research team compared the effects of vitisin A and C3G in two models: HepG2 liver cells exposed to free fatty acids and ApoE−/− mice fed a high-fat diet. The results showed that vitisin A significantly outperformed C3G in reducing triglyceride levels.
In the cell-based experiments, vitisin A reduced triglyceride accumulation more effectively than C3G at equivalent doses. Specifically, cells treated with 200 µM vitisin A exhibited a 44.7% reduction in triglyceride levels, compared to a 31.9% reduction with the same concentration of C3G. These findings indicated that vitisin A had a stronger lipid-lowering effect.
In the animal study, the ApoE−/− mice that were given vitisin A for 12 weeks experienced a 19.6% reduction in body weight gain and a 29.5% decrease in plasma triglyceride levels. In contrast, C3G supplementation did not result in significant triglyceride reductions. Additionally, vitisin A improved liver health by lowering hepatic triglyceride levels and reducing liver damage indicators such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
How Vitisin A Lowers Triglycerides
The study identified two primary mechanisms through which vitisin A effectively reduces triglycerides:
-Inhibition of Hepatic De Novo Lipogenesis (DNL) - The liver produces triglycerides from excess carbohydrates through a process called de novo lipogenesis. The researchers found that vitisin A suppressed this process by activating the AMPK/ACC pathway, which in turn downregulated fatty acid synthase (FASN), an enzyme responsible for triglyceride formation. This inhibition was significantly stronger with vitisin A compared to C3G.
-Enhanceme
nt of Fatty Acid Oxidation - Vitisin A also stimulated the breakdown of stored fats for energy by upregulating key enzymes involved in mitochondrial and peroxisomal fatty acid oxidation. It activated carnitine palmitoyltransferase-1A (CPT-1A), a key enzyme responsible for transporting fatty acids into mitochondria for energy production. This process was mediated by the AMPK/SIRT1/PGC-1α and PPAR-α/PGC-1α pathways, which play crucial roles in fat metabolism.
Study Conclusions and Future Research
The findings of this study suggest that vitisin A holds great potential as a functional food ingredient or supplement for individuals looking to manage high triglyceride levels. Unlike C3G, vitisin A effectively targets multiple pathways in triglyceride metabolism, making it a promising option for reducing lipid accumulation in the liver and bloodstream.
Future research should explore the long-term effects of vitisin A on human triglyceride levels and overall cardiovascular health. Clinical trials are necessary to validate these findings and determine the optimal dosage for human consumption.
The study findings were published in the peer-reviewed International Journal of Molecular Sciences.
https://www.mdpi.com/1422-0067/26/4/1521
For the latest on Triglycerides, keep on logging to Thailand
Medical News.
Read Also:
https://www.thailandmedical.news/news/the-link-between-triglyceride-to-high-density-lipoprotein-ratio-and-heart-failure
https://www.thailandmedical.news/news/the-triglyceride-glucose-tyg-index-set-to-become-a-standard-biomarker-in-the-healthcare-industry
https://www.thailandmedical.news/news/preventing-hypertriglyceridemia-to-reduce-cardiovascular-risk-in-diabetes
https://www.thailandmedical.news/news/covid-19-induces-hypertriglyceridemia-that-prolongs-time-to-death-and-length-of-hospital-stay
Follow us on:
https://x.com/ThailandMedicaX
https://www.facebook.com/ThailandMedicalNews
https://bsky.app/profile/thailandmedical.bsky.social
https://gettr.com/user/thailandmedicalnews
https://www.tribel.com/thailandmedical/wall
and 33 other social media platforms
Share
Tweet
Share
