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The exact pathology behind pre-eclampsia is unknown but is thought to involve abnormal development of the placenta due to problems with the blood vessels that supply it. Studies have shown that inadequate blood supply to the placenta may also lead to the release of certain hormones and chemicals that damage the endothelium, the layer of cells that line blood and lymph vessels, leading to changes in inflammation, metabolism and possibly other reactions.
Some of the factors that are associated with pre-eclampsia pathology include: